AutismKB 2.0

Annotation Detail for FBXO5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FBXO5 ( EMI1,FBX5,Fbxo31 )
Gene Full Name: F-box protein 5
Band: 6q25.2
Quick LinksEntrez ID:26271; OMIM: 606013; Uniprot ID:FBX5_HUMAN; ENSEMBL ID: ENSG00000112029; HGNC ID: 13584
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04114Oocyte meiosis
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Pathway IDPathway Name
200087PLK1 signaling events
No data
Pathway IDPathway Name
500391Regulation of APC/C activators between G1/S and early anaphase
500392Phosphorylation of Emi1
500868Mitotic Metaphase/Anaphase Transition
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FBXO5 proteinaffects expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FBXO5 mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of FBXO5 mRNAincreases expression 16474171
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FBXO5 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine affects the expression of FBXO5 mRNAaffects expression 20106945
D004958 Estradiol Estradiol results in increased expression of FBXO5 mRNAincreases expression 16474171
D005472 Fluorouracil Fluorouracil results in decreased expression of FBXO5 mRNAdecreases expression 16557594
D019833 Genistein Genistein results in increased expression of FBXO5 mRNAincreases expression 16474171
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FBXO5 mRNAaffects binding|decreases expression|increases activity 19710929
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of FBXO5 mRNAincreases expression 16474171
D014212 Tretinoin Tretinoin results in decreased expression of FBXO5 mRNAdecreases expression 18230668
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of FBXO5 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Estradiol 7.3011473722
MESH:D000230 Adenocarcinoma Fluorouracil 7.3017638652
MESH:D000230 Adenocarcinoma Genistein 7.3011473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000740 Anemia Fluorouracil 3.8117963324 16511603 15504547
MESH:D001169 Arthritis, Experimental Tretinoin 3.1416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3716456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3419483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.3416206674 16197459
MESH:D001862 Bone Resorption bisphenol A 3.9711985600
MESH:D001943 Breast Neoplasms bisphenol A 2.3817123778
MESH:D001943 Breast Neoplasms Estradiol 2.3814630087 17289903 16675129 12948864 19861407 18497071 17018787 17261762
MESH:D001943 Breast Neoplasms Fluorouracil 2.3816557594 16110121 19217205 18357371 15136595 18608205 16595493
MESH:D001943 Breast Neoplasms Genistein 2.3816873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tretinoin 2.3816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9218705752 15673190 16097048 16227642 16192424 15700767 16050911 15721981 16011737 16124888 3786805 10355542
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8416051944
MESH:D002277 Carcinoma Fluorouracil 3.6517121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.6212907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.6218788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.6216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.6218930000 17045692 17088986 16332177 16799960 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.6216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.621917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.1417123778
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0618695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8218986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8216096774 16051514
MESH:D002318 Cardiovascular Diseases Genistein 3.3816332659
MESH:D002386 Cataract Tretinoin 3.1517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.5818566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tretinoin 2.719407595
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9117172411 17725105 17169374 16510598 16340194 15001691 18772588 17018589 17287894 17016597
MESH:D003110 Colonic Neoplasms Genistein 3.9117182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8916524972 18288408 18383874 16391804 18802399 17255274 16282729 14970324 17695437 15289873 17401013 18448328 16303861 17016601 18509181 17594712 20501625 18949393 17454858 16331619 15148649 17094418
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.8915531428
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.828800419 16925845 9211117 10589399 9125849 17551590 9664655 14991402 9142499 9224671
MESH:D007644 Darier Disease Fluorouracil 4.9516733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.8116140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.4616684804
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5116647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.076884620 4309450 7179309 15968718 6623471 19336974 10092053 16227642 7120509 10915739 15998439 21278145 3786805 16177239 15027814 11566570 3732212 17522070 2869522 9327722 19085960 7440962
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004489 Edema, Cardiac Tretinoin 4.6418230668
MESH:D004714 Endometrial Hyperplasia Genistein 4.7416402032
MESH:D016889 Endometrial Neoplasms Estradiol 12.8819148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 12.8811473722
MESH:D016889 Endometrial Neoplasms Tretinoin 12.8816569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6020426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6017638652 15173087 16785472 16337965 16481741
MESH:D005124 Eye Abnormalities Tretinoin 3.6616938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.7017595544 15959796 19224547 12795759 16239168 12631006 61145 16045604
MESH:D005234 Fatty Liver Cyclosporine 13.7019224547
MESH:D005234 Fatty Liver pirinixic acid 13.7019236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 15.6318705752
MESH:D005355 Fibrosis Cyclosporine 15.6312639820 12168785
MESH:D005355 Fibrosis Tretinoin 15.6317994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Genistein 7.4416598420
MESH:D005909 Glioblastoma Tretinoin 7.4417312396
MESH:D005910 Glioma Fluorouracil 2.9116145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.0318337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9514991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.1319772884 16221962 18467677 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006930 Hyperalgesia Tretinoin 3.3016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007333 Insulin Resistance bisphenol A 12.7316393666
MESH:D007333 Insulin Resistance Estradiol 12.7316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.7316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0117551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.148314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.1415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9612371664
MESH:D007680 Kidney Neoplasms Estradiol 12.9615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 12.9616985049
MESH:D007938 Leukemia Genistein 6.5818980019 17468513
MESH:D007938 Leukemia Tretinoin 6.5817143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8116482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0917596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2217217047 9834237 12679006 16766008 17506722 17368321 16140955 16331271 17649720 15748426 16823087 17712046 19642359 19075265 17301526 17107899 19225113 17294898 16891316 17361223 17339181 16788101 16935935 19035177 19029980
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8621278145 17157831 11408273 16221502 16943688 17174718 11903743 17334410 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.8716033810 17922224 18472332 18395914 14716496 17481882 17823541 18054572 15052691 16136751 12666154 15931870 14748882 18376398 18277467 18251166 16097048 12445418 20821823 12546737 15650968 16638106 18156304 16248980 18205269 16015684 15673190 17714472 15893842 15730626 18429990 18412020 12958196 15370692 18166357 14512876 15057751 17698563 18705752 18472094 14724832 17805973 10355542 12389079 15123356 17708605 14716833 18210741 16116963 18006644 17900296 15338365 17525996 12649538 18339082 14620537 16011737 15925388 11481614 17761835 18317297 15818738 16192424 17869086 12609069 12898905 12586293 17640975 17631135 17944888 16027843 18279442 18187930 12667390 18481824 17721639 18263696 18420326 13678700 15876570 18418968 12632512 17976157 12445421 15362042 12741479 17557913 17565644 15996030 12632514 15959796 18395095 17766677
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.8714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.8717823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.8715474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.8716248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1015830285 15720792 17285989 16964402 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7916899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.0315890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.0319294768
MESH:D008113 Liver Neoplasms Fluorouracil 11.0315113037 17045692 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 11.0320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.408603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 10.401423854
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.6114755239
MESH:D008175 Lung Neoplasms Fluorouracil 2.6115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9515086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3111408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.3114578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7118986760 16757204
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D009203 Myocardial Infarction Genistein 5.8217141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.8219151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.6716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.6717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.6716411023
MESH:D009369 Neoplasms Fluorouracil 8.5518600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 8.5517405874
MESH:D009369 Neoplasms Tretinoin 8.5516594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 24.5911399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 24.5916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 24.5916427766
MESH:D009421 Nervous System Malformations Tretinoin 24.599125849
MESH:D009436 Neural Tube Defects Tretinoin 3.129142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5116436463
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010024 Osteoporosis Genistein 3.3219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2016169203
MESH:D010049 Ovarian Diseases bisphenol A 5.1411985600
MESH:D010051 Ovarian Neoplasms Estradiol 8.0819401270
MESH:D010051 Ovarian Neoplasms Genistein 8.0819005980
MESH:D010051 Ovarian Neoplasms Tretinoin 8.0816936753
MESH:D010146 Pain Tretinoin 2.9916870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.4616500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4615976015
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4316702228
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1010548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.9220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.9220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8819082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 1.8815378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.8815721890
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D011629 Puberty, Precocious bisphenol A 4.9410548101
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1118286688 15538739 18722050 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.6516467112
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5319015929 18396642 15786421 17522103 16951190 16424979 18567086 17498489 17172411 19084572
MESH:D013274 Stomach Neoplasms Tretinoin 2.5317261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.1416045194 16684133
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1116026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D014062 Tongue Neoplasms Fluorouracil 10.1816280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.1816051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.8016803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.8016129372
MESH:D014591 Uterine Diseases bisphenol A 5.1814652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
KEGG:04114 Oocyte meiosis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved