AutismKB 2.0

Annotation Detail for TINF2


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Basic Information Top
Gene Symbol:TINF2 ( TIN2 )
Gene Full Name: TERF1 (TRF1)-interacting nuclear factor 2
Band: 14q12
Quick LinksEntrez ID:26277; OMIM: 604319; Uniprot ID:TINF2_HUMAN; ENSEMBL ID: ENSG00000092330; HGNC ID: 11824
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Chromosome Maintenance
Pathway IDPathway Name
200072Regulation of Telomerase
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1990Skin disease, Genetic
1841Stomach cancer
No data
No data
Desease Name
Dyskeratosis congenita, autosomal dominant
Revesz syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TINF2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TINF2 mRNAaffects expression 21346803
C006780 bisphenol A bisphenol A results in decreased expression of TINF2 mRNAdecreases expression 19371625
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TINF2 mRNAaffects expression 17484886
D015025 Zearalenone Zearalenone results in decreased expression of TINF2 mRNAdecreases expression 19371625
D019833 Genistein Genistein results in decreased expression of TINF2 mRNAdecreases expression 19371625
C059514 resveratrol resveratrol results in decreased expression of TINF2 mRNAdecreases expression 19371625
C017947 sodium arsenite sodium arsenite results in increased expression of TINF2 mRNAincreases expression 17879257
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 4.0916538975
MESH:D000230 Adenocarcinoma Genistein 2.5211473722
MESH:D000236 Adenoma resveratrol 3.4415688382
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2817306315 16712894
MESH:D000544 Alzheimer Disease resveratrol 2.6116183991 16162502
MESH:D001169 Arthritis, Experimental resveratrol 3.6417115116
MESH:D050197 Atherosclerosis resveratrol 3.4017967414 16873680
MESH:D001862 Bone Resorption bisphenol A 4.1011985600
MESH:D002545 Brain Ischemia resveratrol 4.6217600658
MESH:D001943 Breast Neoplasms bisphenol A 2.0317123778
MESH:D001943 Breast Neoplasms Genistein 2.0316541309 16873071 17200150
MESH:D001943 Breast Neoplasms resveratrol 2.0317534123 17651959 16393696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816011737 10355542 18705752 16227642 16097048 15700767 16124888 15721981 16192424 3786805 16050911 15673190
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.8316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.8316705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.8318788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.8316924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 11.8316227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.8317306315 16507464 15276417
MESH:D002278 Carcinoma in Situ bisphenol A 5.3317123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.9316675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 5.0416227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0418572023
MESH:D002318 Cardiovascular Diseases Genistein 8.0516332659
MESH:D002318 Cardiovascular Diseases resveratrol 8.0515458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.286135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.2820056578 19524636
MESH:D003092 Colitis resveratrol 4.4316474422
MESH:D003110 Colonic Neoplasms Genistein 4.0617182828
MESH:D003110 Colonic Neoplasms resveratrol 4.0616338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D003327 Coronary Disease resveratrol 3.8916507316
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9716873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5316647724
MESH:D003928 Diabetic Nephropathies resveratrol 4.1816286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.596884620 4309450 7179309 3732212 6623471 3786805 15027814 9327722 10092053 15968718 21278145 2869522 7120509 16227642 19336974 10915739 17522070 15998439 7440962 11566570 16177239 19085960
OMIM:127550 DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT, 1 marker/mechanism
MESH:D004487 Edema resveratrol 3.608985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.3117872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.9316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5111473722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.1617923197
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4112795759 15959796 61145 16239168 12631006 19224547 16045604 17595544
MESH:D005355 Fibrosis Carbon Tetrachloride 3.7618705752
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0216452187
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006561 Herpes Simplex resveratrol 4.5216876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.3612676792
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006937 Hypercholesterolemia resveratrol 4.2517188708
MESH:D006949 Hyperlipidemias resveratrol 4.2916873680
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5317488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.9517600658
MESH:D007248 Infertility, Male sodium arsenite 3.1412646999 15346721
MESH:D007249 Inflammation resveratrol 2.9516366677
MESH:D007251 Influenza, Human resveratrol 4.9216624496
MESH:D007333 Insulin Resistance bisphenol A 3.4416393666
MESH:D007674 Kidney Diseases sodium arsenite 2.9220008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D007938 Leukemia Genistein 3.1317468513 18980019
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7216087638
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9217157831 17334410 11903743 21278145 16943688 11408273 17174718 16221502 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.6412445418 16033810 15650968 13678700 16015684 12586293 18472094 15362042 18054572 17805973 12649538 18187930 14620537 18339082 18277467 17557913 17922224 15730626 14748882 17631135 15931870 17900296 17823541 15818738 15052691 18481824 18006644 17766677 18472332 17640975 15925388 16097048 18263696 15338365 12389079 15123356 14716496 18166357 16136751 12898905 17481882 17565644 17698563 17525996 14512876 10355542 15959796 17721639 17976157 18418968 15893842 16027843 16011737 14724832 16638106 18429990 12666154 18205269 17869086 18420326 15370692 18705752 15057751 16116963 12667390 12546737 18251166 12632512 18317297 17944888 18395914 16192424 18395095 18210741 12632514 12609069 20821823 17761835 18412020 16248980 11481614 17714472 12445421 15996030 12958196 18156304 12741479 18376398 18279442 15673190 15876570 17708605 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.6417823541
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1315720792 16246199 17285989 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9216899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.407678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.4019294768
MESH:D008113 Liver Neoplasms resveratrol 11.4019073162 20405173 19321006 19812893
MESH:D008113 Liver Neoplasms sodium arsenite 11.4015276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.392876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3912014681 15583823
MESH:D008171 Lung Diseases sodium arsenite 3.3219095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.8917306315 19931552 15276417 17077188 16712894
MESH:D016393 Lymphoma, B-Cell resveratrol 4.5617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.5815688416
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.7812929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.788985016 11606380
MESH:D008545 Melanoma resveratrol 3.6117992120
MESH:D008545 Melanoma sodium arsenite 3.6116487513 19082730
MESH:D008659 Metabolic Diseases resveratrol 4.6217112576
MESH:D009101 Multiple Myeloma resveratrol 3.6316267019 17049120 17164350 16490592 14749477 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.2117962980
MESH:D009203 Myocardial Infarction Genistein 6.2917141266
MESH:D009203 Myocardial Infarction resveratrol 6.2917125593 17188708 16317513 16525036 16456233 17015251
MESH:D017202 Myocardial Ischemia resveratrol 4.2017125593 17015251
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8417141266
MESH:D009205 Myocarditis resveratrol 5.1017322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.507678174 18551238
MESH:D009369 Neoplasms sodium arsenite 2.6011559025
MESH:D009374 Neoplasms, Experimental resveratrol 10.278985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 10.2720056578
MESH:D009421 Nervous System Malformations bisphenol A 10.8411399458 16427766
MESH:D009421 Nervous System Malformations Genistein 10.8416427766
MESH:D009436 Neural Tube Defects sodium arsenite 3.2912854658
MESH:D019636 Neurodegenerative Diseases resveratrol 4.0117652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.6617929310
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 11.0416169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 11.0417513867
MESH:D010049 Ovarian Diseases bisphenol A 5.3311985600
MESH:D010051 Ovarian Neoplasms Genistein 5.1919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1917306315 15276417
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 11.0210548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 11.0216679765
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0916740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0915378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms resveratrol 2.0915767336 17636462 16731767 17804756 17675339 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0916039940
MESH:D011629 Puberty, Precocious bisphenol A 5.1210548101
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.9616325855
MESH:D015427 Reperfusion Injury resveratrol 3.3715827377 16314181 16317513 17520802 17058453
OMIM:268130 REVESZ SYNDROME marker/mechanism
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D012878 Skin Neoplasms resveratrol 6.298985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 6.2919524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9812854658
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.7116321402
MESH:D019966 Substance-Related Disorders bisphenol A 4.3216045194 16684133
MESH:D014062 Tongue Neoplasms resveratrol 4.4416227395
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7916049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.7916452187 11723127 16712894 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 10.3417473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.3411813266
MESH:D014591 Uterine Diseases bisphenol A 5.3814652134
MESH:D014594 Uterine Neoplasms resveratrol 4.4217044934
MESH:D014652 Vascular Diseases sodium arsenite 4.7617056641
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.6117488730
Pathway ID Pathway Name
REACT:22172 Chromosome Maintenance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36530
    • No data
    Releated disease ID Related disease Name
    PA446872Dyskeratosis Congenita
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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