AutismKB 2.0

Annotation Detail for GATM


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Basic Information Top
Gene Symbol:GATM ( AGAT,AT )
Gene Full Name: glycine amidinotransferase (L-arginine:glycine amidinotransferase)
Band: 15q21.1
Quick LinksEntrez ID:2628; OMIM: 602360; Uniprot ID:GATM_HUMAN; ENSEMBL ID: ENSG00000171766; HGNC ID: 4175
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLYCGREAT-PWYglycine degradation (creatine biosynthesis)
Pathway IDPathway Name
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
hsa00260Glycine, serine and threonine metabolism
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2075Heart failure
Desease Name
RENAL
renal function and chronic kidney disease
Desease Name
Chronic kidney disease
Desease Name
AGAT deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of GATM mRNAdecreases expression 20406850
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of GATM mRNAincreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GATM mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GATM proteinaffects expression 20106945
D000641 Ammonia Ammonia results in decreased activity of GATM proteindecreases activity 20227315
D003345 Corticosterone Corticosterone results in decreased expression of GATM mRNAdecreases expression 15755911
D003401 Creatine GATM protein results in increased chemical synthesis of Creatineincreases chemical synthesis 18428409
D016572 Cyclosporine Cyclosporine results in decreased expression of GATM mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of GATM mRNAincreases expression 18042831
D004958 Estradiol Estradiol results in decreased expression of GATM mRNAdecreases expression 20106945
C010176 halofuginone halofuginone results in increased expression of GATM mRNAincreases expression 17180598
C029938 nickel sulfate nickel sulfate results in decreased expression of GATM mRNAdecreases expression 16780908
C041786 palm oil palm oil results in increased expression of GATM mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of GATM mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of GATM mRNAdecreases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of GATM mRNAincreases expression 19270015
C025299 polyphenols polyphenols results in decreased expression of GATM mRNAdecreases expression 16293270
D018038 Sodium Selenite Sodium Selenite results in decreased expression of GATM mRNAdecreases expression 18175754
D014284 Triiodothyronine Triiodothyronine results in decreased expression of GATM mRNAdecreases expression 19228888
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GATM mRNAdecreases expression 20106945
D014212 Tretinoin Tretinoin results in decreased expression of GATM mRNAdecreases expression 18230668
C015559 trimellitic anhydride trimellitic anhydride results in increased expression of GATM mRNAincreases expression 16141432
D014635 Valproic Acid Valproic Acid results in increased expression of GATM mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.576195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.5715322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.578875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8319490988
MESH:D055371 Acute Lung Injury nickel sulfate 4.2011954676 12718980 19131640 16100012
MESH:D000230 Adenocarcinoma Estradiol 2.0711473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.693712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.7217620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7216835633
MESH:D000505 Alopecia Tretinoin 3.5315955085
MESH:D000550 Amblyopia Valproic Acid 5.1317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.4817497229
OMIM:612718 ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY marker/mechanism
MESH:D001161 Arteriosclerosis Dietary Fats 3.7815238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 5.3216456186
MESH:D001249 Asthma trimellitic anhydride 5.3216141432
MESH:D001321 Autistic Disorder Creatine 3.0116818868
MESH:D001321 Autistic Disorder Valproic Acid 3.0120603192 18396377 18558336 17688650 18316065 18177632 17507914 16609825 18985861 18775368 15238991 18940202 17157402 19460635 19232924
MESH:D001471 Barrett Esophagus Tretinoin 4.2916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9111289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.0220046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.798888407
MESH:D001929 Brain Edema Ammonia 6.1711481608 19393034 20217200
MESH:D001943 Breast Neoplasms Dietary Fats 1.9120435547
MESH:D001943 Breast Neoplasms Estradiol 1.9114630087 17289903 18497071 12948864 17261762 19861407 17018787 16675129
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9116166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0516168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.1616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.163581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.1612907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.1616924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.1617173139 20007298 6705139 20935162 1701930
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.161917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2616096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3116120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 3.0317460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.386135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.387505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.3812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.3818566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.144080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.6019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 7.6019486331
MESH:D002822 Choriocarcinoma Tretinoin 5.0516461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6415894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6112621046 16354765 15668235 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 5.619407595
MESH:D003092 Colitis Tretinoin 3.6017035595
MESH:D003110 Colonic Neoplasms polyphenols 2.6616293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6920055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.698800419 10589399 9142499 17551590 9125849 16925845 9664655 9224671 14991402 9211117
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.6917688650 8888407 16575769
MESH:C535598 Creatine deficiency, X-linked Creatine 7.3212210795
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9118551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 11.232524372 11298694 11906362 8970840 14531868 8156756 12868966 18759878
MESH:D017449 Dermatitis, Allergic Contact Ammonia 11.2316823706
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 11.2316823706 11298694 16780908
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.393621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6816285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3219279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.8518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.8518692083 18648102 9022650 9328219 18289764 6482804 7440962 16192314 6679447 11289319 1440618 9653073 8291058
MESH:D056486 Drug-Induced Liver Injury polyphenols 14.8519370779
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 14.8515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.8520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 14.851733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3718367378
MESH:D004421 Dystonia Phenobarbital 10.091851702
MESH:D004421 Dystonia Valproic Acid 10.091851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5915322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.5918230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.1711473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.1716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.433659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.4317275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.623922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 9.623922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.4820417680
MESH:D004827 Epilepsy Valproic Acid 6.4818234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 8.556401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.556426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.947750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.947750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.123659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.123659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.083581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5611564622
MESH:D005124 Eye Abnormalities Tretinoin 8.5616938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 12.5419224547
MESH:D005234 Fatty Liver Dietary Fats 12.5417967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Valproic Acid 12.5419224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.0218558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Cyclosporine 20.2412639820 12168785
MESH:D005355 Fibrosis Dietary Fats 20.2418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.2420067830
MESH:D005355 Fibrosis Tretinoin 20.2417994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D005909 Glioblastoma Tretinoin 2.9317312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.349664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006501 Hepatic Encephalopathy Ammonia 5.7212420312 16338762 20549931
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.416705139
MESH:D006529 Hepatomegaly Phenobarbital 8.0816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0812621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D019584 Hot Flashes Estradiol 3.6517088409
MESH:D006849 Hydrocephalus Valproic Acid 4.7617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.948697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.1216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4921332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4616778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.5121332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.7715034207
MESH:D006965 Hyperplasia halofuginone 10.7711874485
MESH:D006973 Hypertension Cyclosporine 4.8110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8118670907 18850075
MESH:D007249 Inflammation Dietary Fats 8.0420412841
MESH:D007249 Inflammation polyphenols 8.0416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0412878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 11.9611836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.9616393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 11.9614714311
MESH:D007410 Intestinal Diseases Tretinoin 3.6617994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.919022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5916580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5915992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Cyclosporine 5.738314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 5.7315618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.9916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.996582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.9912371664
MESH:D007680 Kidney Neoplasms Estradiol 16.9915610895
MESH:D007938 Leukemia Tretinoin 2.7217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6019285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8216294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8216294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0815748426 19075265 16331271 16788101 17368321 17712046 16766008 19035177 17217047 17361223 12679006 17339181 19029980 9834237 16140955 17107899 17301526 17649720 19225113 19642359 16935935 17294898 17506722 16891316 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.239224671
MESH:D008103 Liver Cirrhosis Dietary Fats 10.8418296743
MESH:D008103 Liver Cirrhosis halofuginone 10.8417180598
MESH:D008103 Liver Cirrhosis Phenobarbital 10.8421047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.139327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 4.8918458672 12175628 11172339 16489207 14739098
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.8918397230 16248980
MESH:D008107 Liver Diseases Phenobarbital 4.2619363144
MESH:D008107 Liver Diseases polyphenols 4.2616698588
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.357678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.3518177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Phenobarbital 10.3519812893 21047994 15975961 19073162 19482888 8742319
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.3516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.912876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.91598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.918603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.912563599 1399818 6150874 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.9112151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1617228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.2614755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2619555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9514737004
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 6.1012807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1016891317 11807958 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.3819453300
MESH:D008527 Medulloblastoma Tretinoin 2.7417453147
MESH:D008545 Melanoma Tretinoin 1.9316752155
MESH:D008591 Meningomyelocele Tretinoin 4.3216940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.928888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.1917596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.1917596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1916810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3717484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.433581430
MESH:D009369 Neoplasms Tretinoin 2.3616946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1919348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 15.7116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.7114600291
MESH:D009421 Nervous System Malformations Tretinoin 15.719125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.716679447
MESH:D009436 Neural Tube Defects Tretinoin 11.719142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.7116359493 8888407
MESH:D009765 Obesity Dietary Fats 2.2621332399 20132043 20518802 16723640 17217161 19632207 18457598 11836018 18674790
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.5516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.554026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010018 Osteomalacia Phenobarbital 4.2617016548
MESH:D010051 Ovarian Neoplasms Estradiol 4.6919401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6916936753
MESH:D010146 Pain Tretinoin 2.8116870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.1516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.1515976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.6512371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.652563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.1011399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.1020603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7820887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.3016740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3018760546
MESH:D011507 Proteinuria Tretinoin 3.5016636307
MESH:D019310 Pseudolymphoma Phenobarbital 11.8412752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.8411422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D011625 Pterygium Tretinoin 4.6816723453
MESH:D012130 Respiratory Hypersensitivity trimellitic anhydride 4.7920219652
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.5116283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.5119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0515737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 9.4018551238
MESH:D012640 Seizures Phenobarbital 9.403137016 16876388 4039156 11442880
MESH:D012640 Seizures Valproic Acid 9.4011044598 15475178 14763951 11738929 3137016 17978042 1511512 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.716407741
MESH:D012871 Skin Diseases halofuginone 3.4911874485
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3916192470
MESH:D012878 Skin Neoplasms Tretinoin 5.3916467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4412833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.1517997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.473712494 6582329 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.471399818
MESH:D013964 Thyroid Neoplasms Tretinoin 11.4716026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.5819048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6916051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.1317262798
MESH:D014376 Tuberculosis Tretinoin 3.1616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.413119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.8716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.878074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.538888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2110091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5016752155
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D014820 Vitiligo Tretinoin 3.9516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D015430 Weight Gain Dietary Fats 3.6416723640
MESH:D009396 Wilms Tumor Tretinoin 3.8716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
KEGG:00330 Arginine and proline metabolism
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28590
    • No data
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    PA448478l-arginine
    PA449014cisplatin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00129 - L-Ornithine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
    DB02068 - Delta-Amino Valeric Acid
    DB02530 - Gamma(Amino)-Butyric Acid GABA Agents
    DB03131 - Beta-Mercaptoethanol
    DB04185 - Norvaline
    DB04454 - Alpha-Aminobutyric Acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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