AutismKB 2.0

Annotation Detail for ARFGAP3


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Basic Information Top
Gene Symbol:ARFGAP3 ( ARFGAP1,FLJ45618 )
Gene Full Name: ADP-ribosylation factor GTPase activating protein 3
Band: 22q13.2
Quick LinksEntrez ID:26286; OMIM: 612439; Uniprot ID:ARFG3_HUMAN; ENSEMBL ID: ENSG00000100266,ENSG00000242247; HGNC ID: 661
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ARFGAP3 mRNAincreases expression 19933214
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ARFGAP3 mRNAdecreases expression 20127859
D016572 Cyclosporine Cyclosporine results in increased expression of ARFGAP3 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of ARFGAP3 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of ARFGAP3 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ARFGAP3 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of ARFGAP3 mRNAdecreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARFGAP3 mRNAaffects binding|decreases expression|increases activity 19710929
D018038 Sodium Selenite Sodium Selenite results in increased expression of ARFGAP3 mRNAincreases expression 18175754
D014212 Tretinoin Tretinoin results in increased expression of ARFGAP3 mRNAincreases expression 16604517
D014415 Tunicamycin Tunicamycin results in increased expression of ARFGAP3 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.686195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.9317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.9316434500
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.5516206674 16197459
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8817474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.8820435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.131701930 17173139 6705139 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.131917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7120419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7116096774 16051514
MESH:D002386 Cataract Tretinoin 3.1917460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9715894690
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829211117 16925845 9142499 17551590 8800419 10589399 9224671 9125849 9664655 14991402
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9316285004
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.3215131321
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.143922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tretinoin 3.709664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 14.0819224547
MESH:D005234 Fatty Liver Dietary Fats 14.0818296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver pirinixic acid 14.0820131406 19236843
MESH:D005355 Fibrosis Cyclosporine 16.1012168785 12639820
MESH:D005355 Fibrosis Dietary Fats 16.1018296743
MESH:D005355 Fibrosis Tretinoin 16.1017994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9320471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.9314991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly Phenobarbital 9.2116109766
MESH:D006529 Hepatomegaly pirinixic acid 9.2118467677 19772884 16221962 19176532
MESH:D006930 Hyperalgesia Tretinoin 3.3516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007249 Inflammation Dietary Fats 2.5120412841
MESH:D007333 Insulin Resistance Dietary Fats 12.9711836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 12.9716306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.9714714311
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0715992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.438314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2619035177 19225113 16788101 17217047 9834237 17361223 19642359 16140955 19075265 16935935 17712046 17506722 15748426 16823087 17339181 17294898 16766008 16891316 17107899 17301526 16331271 19029980 17368321 12679006 17649720
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9518296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.9521047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3918397230 16248980
MESH:D008107 Liver Diseases Phenobarbital 2.2019363144
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7321137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 7.738742319 21047994 19482888 15975961 19812893 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 7.7320007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.801399818 17172636 6150874 18308698 2563599
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5620064080 18520028 20869020 17053015 6695378 20464547 18569708 18816296 20135361
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2414737004
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6511141357
MESH:D009369 Neoplasms pirinixic acid 8.6517405874
MESH:D009369 Neoplasms Tretinoin 8.6516946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D009765 Obesity Dietary Fats 4.5621332399 20518802 19632207 18674790 18457598 20132043 11836018 17217161 16723640
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3916936753
MESH:D010146 Pain Tretinoin 3.0416870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4616965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4615976015
MESH:D011230 Precancerous Conditions Cyclosporine 9.4812371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.482563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1817292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.1818760546
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012640 Seizures Phenobarbital 2.8011442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9219755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 5.9216467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3820155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3817261132
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.631399818
MESH:D013964 Thyroid Neoplasms Tretinoin 7.6316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:04144 Endocytosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35024
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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