AutismKB 2.0

Annotation Detail for EHF


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Basic Information Top
Gene Symbol:EHF ( ESE3,ESEJ )
Gene Full Name: ets homologous factor
Band: 11p13
Quick LinksEntrez ID:26298; OMIM: 605439; Uniprot ID:EHF_HUMAN; ENSEMBL ID: ENSG00000135373; HGNC ID: 3246
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00047PDGF signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1848Embryoma
Desease Name
Volumetric brain MRI
NEUROLOGICAL
Desease Name
Volumetric brain MRI
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of EHF mRNAaffects expression 17331233
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of EHF mRNA]affects reaction|decreases expression 15016801
D017239 Paclitaxel Paclitaxel results in decreased expression of EHF mRNAdecreases expression 19682730
C006253 pirinixic acid pirinixic acid results in increased expression of EHF mRNAincreases expression 17426115
C089730 rosiglitazone rosiglitazone results in increased expression of EHF mRNAincreases expression 16982809
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of EHF mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.249612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000544 Alzheimer Disease rosiglitazone 2.9019621015
MESH:D000740 Anemia Fluorouracil 4.0216511603 15504547 17963324
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001859 Bone Neoplasms Paclitaxel 4.9215867366
MESH:D001943 Breast Neoplasms Fluorouracil 2.4716557594 16595493 18357371 15136595 18608205 19217205 16110121
MESH:D001943 Breast Neoplasms Paclitaxel 2.4711325840 16273361 16115903 18234424 15136595 18323546 16244791 18223236
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.4817088986 16332177 16799960 17045692 17971768 18930000
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 3.4816313753
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5617066447 16280240 18986760 16757204
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2716340194 16510598 17169374 17172411 18772588 17287894 15001691 17018589 17016597 17725105
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8217401013 16524972 18288408 16391804 15289873 18448328 18383874 20501625 16303861 17094418 17016601 17255274 17594712 18949393 17454858 14970324 18509181 16282729 18802399 15148649 16331619 17695437
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.8218802399
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.5917446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 2.9912642470
MESH:D004362 Drug Toxicity Zidovudine 4.2315040536
MESH:D004487 Edema pirinixic acid 8.1012083418
MESH:D004487 Edema rosiglitazone 8.1012083418
MESH:D004938 Esophageal Neoplasms Fluorouracil 5.0315173087 16785472 16337965 17638652 16481741
MESH:D004938 Esophageal Neoplasms Paclitaxel 5.0316481741
MESH:D005234 Fatty Liver pirinixic acid 15.2619236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 15.2619196556
MESH:D005234 Fatty Liver Zidovudine 15.2618299183
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5915102660 15162350 18337622
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006402 Hematologic Diseases Zidovudine 5.0612579204
MESH:D006529 Hepatomegaly pirinixic acid 3.4118467677 19772884 19176532 16221962
MESH:D015658 HIV Infections Zidovudine 3.6317358032 11698656 11141242 11363243 20032539
MESH:D006930 Hyperalgesia rosiglitazone 4.1712083418
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007249 Inflammation rosiglitazone 3.2612083418
MESH:D007333 Insulin Resistance pirinixic acid 8.1516306350
MESH:D007333 Insulin Resistance rosiglitazone 8.1516306350
MESH:D007680 Kidney Neoplasms Fluorouracil 8.6916985049
MESH:D007680 Kidney Neoplasms Zidovudine 8.6912579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.7420370541
MESH:D008080 Liposarcoma Paclitaxel 5.1717353645
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.6815474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 2.6817347453 15980055
MESH:D008113 Liver Neoplasms Fluorouracil 4.8616603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 4.8620007298 15890375 16377806
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.4417365036
MESH:D008175 Lung Neoplasms Fluorouracil 2.8715246190
MESH:D008175 Lung Neoplasms Zidovudine 2.8718800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.3614749477
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.5816827153
MESH:D008545 Melanoma Paclitaxel 2.6212040289 12025231 16342250
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2816166281 18303189 16966607
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.6417261469
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.3617358032
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8716757204 18986760
MESH:D009101 Multiple Myeloma Paclitaxel 3.9014749477
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.3515867366
MESH:D009369 Neoplasms Fluorouracil 5.4418239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 5.4417405874
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010014 Osteolysis Paclitaxel 5.4415867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0611161223
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7515113037 16929163 16500647 19003803
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.3110923243
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.4918626508 19082440
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.4917172428 16356831 17136230 16729912
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1317975199 17365031 17322281 15814490
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3015538739 16160472 18286688 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D013274 Stomach Neoplasms Fluorouracil 3.7017172411 18396642 18567086 17522103 16951190 15786421 19015929 19084572 17498489 16424979
MESH:D013274 Stomach Neoplasms Paclitaxel 3.7018506536 18396642
MESH:D013274 Stomach Neoplasms Zidovudine 3.7017696246
MESH:D024801 Tauopathies Paclitaxel 5.2716930453
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
MESH:D014625 Vaginal Neoplasms Zidovudine 5.1812579204
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27681
    • No data
    Releated disease ID Related disease Name
    PA443450Asthma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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