AutismKB 2.0

Annotation Detail for GBE1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GBE1 ( GBE )
Gene Full Name: glucan (1,4-alpha-), branching enzyme 1
Band: 3p12.2
Quick LinksEntrez ID:2632; OMIM: 607839; Uniprot ID:GLGB_HUMAN; ENSEMBL ID: ENSG00000114480; HGNC ID: 4180
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5067glycogen biosynthesis II (from UDP-D-Glucose)
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00500Starch and sucrose metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
No data
No data
Pathway IDPathway Name
500679Glycogen synthesis
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of carbohydrate metabolism
H00069Glycogen storage disease (GSD)
Genetic disorders
Desease IDDesease Name
1951Overnutrition
2182Glycogen storage disease
No data
No data
Desease Name
Glycogen storage disease IV
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GBE1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GBE1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of GBE1 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of GBE1 mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of GBE1 mRNAaffects expression 19483382
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GBE1 mRNAaffects expression 17484886
D002794 Choline Choline affects the expression of GBE1 mRNAaffects expression 17616785
D002994 Clofibrate Clofibrate affects the expression of GBE1 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in increased expression of GBE1 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of GBE1 mRNAdecreases expression 18042831
D005001 Ethionine Ethionine affects the expression of GBE1 mRNAaffects expression 19483382
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of GBE1 mRNAincreases expression 16849584
D009853 Omeprazole Omeprazole affects the expression of GBE1 mRNAaffects expression 19483382
C041786 palm oil palm oil results in decreased expression of GBE1 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GBE1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of GBE1 mRNAincreases expression 19482888
19270015
C006253 pirinixic acid pirinixic acid results in increased expression of GBE1 mRNAincreases expression 17426115
C006253 pirinixic acid pirinixic acid affects the expression of GBE1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of GBE1 mRNAaffects expression 19483382
C031280 pyrazole pyrazole results in increased expression of GBE1 mRNAincreases expression 17945193
D011794 Quercetin Quercetin results in increased expression of GBE1 mRNAincreases expression 19729006
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of GBE1 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GBE1 mRNAincreases expression 19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GBE1 mRNAincreases expression 16267337
D013853 Thioacetamide Thioacetamide affects the expression of GBE1 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.936195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9315322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.693712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.6617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.6616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.1417084956
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7018218290 20041841 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 3.7815238619
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8715336622
MESH:D001281 Atrial Fibrillation Amiodarone 3.8219698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 2.3518445737
MESH:D001321 Autistic Disorder Choline 2.3516818868
MESH:D001327 Autoimmune Diseases Quercetin 4.3019761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9111289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 56.5019483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 56.5019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 56.5019483382
MESH:D001778 Blood Coagulation Disorders Ethionine 56.5019483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 56.5019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 56.5019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 56.5019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 56.5012125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 56.5019483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.8920435547
MESH:D001943 Breast Neoplasms Quercetin 1.8918628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002105 Cadmium Poisoning Quercetin 5.4416962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6716124888 15673190 18705752 16227642 16011737 16192424 16097048 15721981 10355542 15700767 3786805 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.6416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.643581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.643084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 16.641701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.6418788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.6420007298 17173139 20935162 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular Quercetin 16.6419519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 16.6417997003
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8517234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D006332 Cardiomegaly Quercetin 6.6019794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6018670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8615710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9818974383
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.807505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 10.801399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.8012371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.144080065
MESH:D002637 Chest Pain Omeprazole 5.0015447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2316835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.2318291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.9019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.9019486331
MESH:D002779 Cholestasis pirinixic acid 12.9019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0615340226 12621046 8697196 15668235 16354765
MESH:D003110 Colonic Neoplasms Quercetin 2.4015741050 11134977 17148506 16640504 19056647 19440933 17191121
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9118551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.702524372 18759878 11906362 8156756 14531868 12868966 11298694 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.393621924 2952479
MESH:D002658 Developmental Disabilities Choline 4.6016818868
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.6419496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 21.7121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 21.719022650 18648102 18692083 11289319 18289764 6679447 16192314 1440618 7440962 9653073 9328219 8291058 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 21.7116781746 16109766 14725611 14986274 19416960 11421492 11461765 12705907 19739265 12958197 11834606 19085960 10774834 15968718 16485898 10915739 19370779 16177239 19420014 17522070 19923254 11287661 10663392 16081117 11529661 17906064 14550746 18071297 16393943 11743745 17562736 16227642 12594235 12540782 12153990 19164858 18713872 2444490 12392966 11739529 15619225
MESH:D056486 Drug-Induced Liver Injury Amiodarone 21.7115265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 21.717440962 3732212 4309450 7179309 17522070 3786805 16227642 10915739 16177239 11566570 19085960 19336974 2869522 15998439 15968718 15027814 9327722 7120509 6884620 10092053 6623471 21278145
MESH:D056486 Drug-Induced Liver Injury pyrazole 21.7112499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 21.7120420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 21.7112963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.2215991576 21218061 17151854 16613094
MESH:D050171 Dyslipidemias Clofibrate 8.5616707586
MESH:D050171 Dyslipidemias Dietary Fats 8.5618367378
MESH:D004421 Dystonia Phenobarbital 3.901851702
MESH:D004487 Edema pirinixic acid 6.2012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8018230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.003659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.773922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.456401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.147750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.913659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.083581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005218 Fat Necrosis Thioacetamide 5.6116456712
MESH:D005234 Fatty Liver Amiodarone 29.4114986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.4119224547 12631006 12795759 16239168 17595544 15959796 16045604 61145
MESH:D005234 Fatty Liver Clofibrate 29.4119224547
MESH:D005234 Fatty Liver Cyclosporine 29.4119224547
MESH:D005234 Fatty Liver Dietary Fats 29.4117967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 29.4119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Carbon Tetrachloride 26.5818705752
MESH:D005355 Fibrosis Cyclosporine 26.5812639820 12168785
MESH:D005355 Fibrosis Dietary Fats 26.5818296743
MESH:D005355 Fibrosis Quercetin 26.5819474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 26.5820067830
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D005909 Glioblastoma Quercetin 3.3219804834
MESH:D005910 Glioma Quercetin 3.0117643826
MESH:D006011 Glycogen Storage Disease Type IV marker/mechanism
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4718665440 15929193 17276928
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 15.106705139
MESH:D006505 Hepatitis Carbon Tetrachloride 15.1019900420 19110552
MESH:D006505 Hepatitis Thioacetamide 15.1016456712
MESH:D006529 Hepatomegaly Amiodarone 19.7815265979
MESH:D006529 Hepatomegaly Phenobarbital 19.7816109766
MESH:D006529 Hepatomegaly pirinixic acid 19.7816221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.7815340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.948697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4216899240
MESH:D006937 Hypercholesterolemia Amiodarone 8.838137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 8.8321332399
MESH:D006943 Hyperglycemia pirinixic acid 8.9120558911
MESH:D006943 Hyperglycemia Quercetin 8.9111834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 3.5121332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Cyclosporine 8.3410903974
MESH:D006973 Hypertension Quercetin 8.3418356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9815338365
MESH:D007037 Hypothyroidism Amiodarone 11.2517991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.2518031379 8137927
MESH:D007249 Inflammation Dietary Fats 4.7320412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7312878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.4016624496
MESH:D007333 Insulin Resistance Dietary Fats 7.0118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.0116306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.918074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007627 Keloid Quercetin 4.8517086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Acetaminophen 9.6815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.6818776723 8314463 10903974
MESH:D007674 Kidney Diseases Quercetin 9.6816962696
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.8316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.836582329
MESH:D007680 Kidney Neoplasms Cyclosporine 11.8312371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0019248655
MESH:D007938 Leukemia Quercetin 3.1017468513
MESH:D008064 Lipidoses Amiodarone 3.4315342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.6817157831 17334410 11903743 17174718 16221502 16943688 16239168 11408273 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 10.6818296743
MESH:D008103 Liver Cirrhosis Phenobarbital 10.6821047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.139327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5915818738 13678700 14748882 17805973 12389079 12667390 14716496 16248980 12898905 16192424 17922224 15876570 16011737 12632512 18006644 17640975 12609069 18156304 18054572 18418968 15931870 17525996 18376398 17766677 17557913 18395914 17823541 18210741 18420326 12445421 17869086 18187930 18472332 17631135 12546737 12741479 12632514 11481614 16015684 12586293 15370692 14716833 15338365 20821823 18412020 18205269 17761835 18263696 12666154 16033810 17698563 17900296 17714472 14724832 16638106 16097048 15730626 15893842 18251166 12958196 14620537 15959796 14512876 15996030 12649538 18429990 16136751 18279442 12445418 17565644 15673190 15362042 17708605 15650968 17976157 17944888 18472094 18339082 18395095 18317297 15925388 16116963 17481882 18705752 18277467 15057751 10355542 15123356 16027843 17721639 18481824 18166357 15052691
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.5912741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5912878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.5918606216 16126171 16248980 17629604 18458672 11682029 12891558 15095483 16097051 18295389 12085344 16343077 10677585 11172339 14739098 15316131 17050028 15474484 16489207 18032466 15334695 18395095 11481614 15078482 18416461 15288472 15465738 17355460 16098781 18380797 15075984 15716488 15288473 15158331 16511523 18031379 12531686 17292413 12175628 12557150 18615449 17127702 15362042 18263696 12679928
MESH:D008107 Liver Diseases Acetaminophen 9.1616610002 19784758 11587558 12969438 16611625 12587719 19014921 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.1615830285 16964402 17285989 16246199 15720792
MESH:D008107 Liver Diseases Phenobarbital 9.1619363144
MESH:D008107 Liver Diseases Thioacetamide 9.1618374380 15158337 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.6816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.6814706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 15.6817276928 15633222 12479984 15313186
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.8019294768
MESH:D008113 Liver Neoplasms Phenobarbital 13.808742319 19812893 19073162 21047994 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 13.8020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 13.8018980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8016984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.92598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.9212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.921399818 18308698 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Quercetin 17.9219519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.9212151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4915350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.3012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3718516814
MESH:D008175 Lung Neoplasms Quercetin 2.3816280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3811884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009181 Mycoses Amiodarone 4.8017974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 5.5819151258
MESH:D009203 Myocardial Infarction Quercetin 5.5819595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.1519207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.433581430
MESH:D009369 Neoplasms pirinixic acid 4.8717405874
MESH:D009369 Neoplasms Quercetin 4.8715185748
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1919348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.846679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7818514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.2617929310
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.839802331
MESH:D009765 Obesity Dietary Fats 4.3411836018 21332399 18674790 17217161 20518802 16723640 19632207 18457598 20132043
MESH:D009765 Obesity pirinixic acid 4.3420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.5516049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010018 Osteomalacia Phenobarbital 4.2617016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.1119495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7019005980
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.2916965848
MESH:D010190 Pancreatic Neoplasms Quercetin 5.2916965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.7812371664
MESH:D011230 Precancerous Conditions Phenobarbital 14.782563599
MESH:D011230 Precancerous Conditions Quercetin 14.7819056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0811896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Quercetin 3.6314715546 17292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.3912752131
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8112832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012554 Schistosomiasis japonica Quercetin 5.4416862918
MESH:D012640 Seizures 2,4-dinitrotoluene 5.6818551238
MESH:D012640 Seizures Phenobarbital 5.683137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.716407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9818724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9916192470
MESH:D013272 Stomach Diseases Omeprazole 4.5018545984
MESH:D013276 Stomach Ulcer Amiodarone 7.2418087811
MESH:D013276 Stomach Ulcer Omeprazole 7.2417977527 18237397 15991576 16755016 11906479 10750652
MESH:D013610 Tachycardia Amiodarone 4.1811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0819225199
MESH:D013733 Testicular Diseases pyrazole 4.716499806
MESH:D013959 Thyroid Diseases Amiodarone 11.7019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.7012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.566587162 6582329 3712494 1399818 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.561399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 11.5615710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.7519584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.0811989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.1016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.108074119
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.1016720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2110091137
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D015430 Weight Gain Dietary Fats 3.6416723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:00500 Starch and sucrose metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28594
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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