AutismKB 2.0

Annotation Detail for GBP1


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Basic Information Top
Gene Symbol:GBP1 ( - )
Gene Full Name: guanylate binding protein 1, interferon-inducible, 67kDa
Band: 1p22.2
Quick LinksEntrez ID:2633; OMIM: 600411; Uniprot ID:GBP1_HUMAN; ENSEMBL ID: ENSG00000117228; HGNC ID: 4182
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1861Epstein-Barr virus infection
1926Inflammation of the central nervous system
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000111 Acetylcysteine Acetylcysteine results in decreased expression of GBP1 mRNAdecreases expression 16084531
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GBP1 proteinaffects expression 20106945
C430898 AGN 194204 AGN 194204 results in decreased expression of GBP1 mRNAdecreases expression 16339527
C004984 apocarotenal apocarotenal results in increased expression of GBP1 mRNAincreases expression 17034753
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GBP1 mRNAincreases expression 20382639
D019207 beta Carotene beta Carotene results in increased expression of GBP1 mRNAincreases expression 17034753
C006780 bisphenol A bisphenol A affects the expression of GBP1 mRNAaffects expression 20170705
C459604 candoxin candoxin results in increased expression of GBP1 mRNAincreases expression 16309724
D016572 Cyclosporine Cyclosporine results in decreased expression of GBP1 mRNAdecreases expression 20106945
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of GBP1 mRNAdecreases expression 16084531
D004958 Estradiol Estradiol results in decreased expression of GBP1 mRNAdecreases expression 16705744
D019833 Genistein Genistein results in decreased expression of GBP1 mRNAdecreases expression 16705744
D007213 Indomethacin Indomethacin results in decreased expression of GBP1 mRNAdecreases expression 16984733
D012643 Selenium Selenium results in decreased expression of GBP1 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite affects the expression of GBP1 mRNAaffects expression 19590694
C004648 testosterone enanthate testosterone enanthate affects the expression of GBP1 mRNAaffects expression 17440010
C066075 vanadium pentoxide vanadium pentoxide affects the expression of GBP1 mRNAaffects expression 17459161
D014810 Vitamin E Vitamin E results in decreased expression of GBP1 mRNAdecreases expression 19244175
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP1 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.769612607
MESH:D000230 Adenocarcinoma Estradiol 7.1011473722
MESH:D000230 Adenocarcinoma Genistein 7.1011473722
MESH:D000230 Adenocarcinoma Indomethacin 7.1016537180
MESH:D000236 Adenoma Indomethacin 3.4111497255
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8517306315 16712894
MESH:D016301 Alveolar Bone Loss Indomethacin 5.3217225004
MESH:D000544 Alzheimer Disease Indomethacin 2.6917627676 15579461
MESH:D001014 Aortic Aneurysm Indomethacin 4.7810231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.8110388637
MESH:D018771 Arthralgia Indomethacin 5.112160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8111248219
MESH:D001249 Asthma epigallocatechin gallate 3.3716516891
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 5.0019761891
MESH:D001477 Bartter Syndrome Indomethacin 4.9210684365
MESH:D001862 Bone Resorption bisphenol A 3.8011985600
MESH:D001929 Brain Edema Indomethacin 4.9711481608
MESH:D002545 Brain Ischemia beta Carotene 10.4516157235
MESH:D002545 Brain Ischemia Indomethacin 10.4512524144
MESH:D001943 Breast Neoplasms bisphenol A 2.0017123778
MESH:D001943 Breast Neoplasms Estradiol 2.0018497071 17289903 14630087 12948864 19861407 17261762 16675129 17018787
MESH:D001943 Breast Neoplasms Genistein 2.0016873071 17200150 16541309
MESH:D001943 Breast Neoplasms Indomethacin 2.0017401462
MESH:D001991 Bronchitis vanadium pentoxide 6.1817459161
MESH:D002056 Burns Indomethacin 4.6410459503
MESH:D002100 Cachexia Indomethacin 4.9411239499 15625704 15141370 16537180
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8716050911
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.7821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.7816924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.7816924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.7816391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.7815276417 16507464 17306315
MESH:D002278 Carcinoma in Situ bisphenol A 4.9317123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.6611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2918791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.3417341418
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 7.6417015178
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 7.6412636206 15482327
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.6418572023
MESH:D002318 Cardiovascular Diseases Genistein 3.2616332659
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.6220889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 20.6218226522
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.6212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.6218566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 20.6219524636 20056578
MESH:D002764 Cholecystitis Indomethacin 5.1111181007
MESH:D002779 Cholestasis Cyclosporine 2.8719486331
MESH:D003092 Colitis Selenium 3.7217936198
MESH:D003110 Colonic Neoplasms Genistein 3.9417182828
MESH:D003110 Colonic Neoplasms Indomethacin 3.9415637740 15786552 11260862 15963497 15936596 15625704
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3517054584 12606626 18059344 11197048
MESH:D018352 Coronavirus Infections Indomethacin 5.6617302372
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.3119747007
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 4.8716988119
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.8716647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.3519279558
MESH:D003967 Diarrhea Indomethacin 3.737907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 4.2711287661
MESH:D056486 Drug-Induced Liver Injury Selenium 4.2715131321
MESH:D004362 Drug Toxicity Zidovudine 3.9515040536
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0918446180 18043480 16133044 12774134 16326151 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 4.0711535926 17351913 17045617 16699067 17151854 11595415 17329845 11595431 11991626 17202747 10671773
MESH:C538011 Eales disease Vitamin E 4.659068938
MESH:D004487 Edema Indomethacin 3.447907874 10653021 16100529 19703484 8273558 7990266 8985016
MESH:D004714 Endometrial Hyperplasia Genistein 4.5316402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.3611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.3611473722
MESH:D004715 Endometriosis Indomethacin 4.0815652904
MESH:D019446 Endotoxemia Indomethacin 4.4418509659
MESH:D004751 Enteritis Indomethacin 4.6910567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.9217980183
MESH:D004802 Eosinophilia Indomethacin 3.9911298111
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5920426865
MESH:D004938 Esophageal Neoplasms Indomethacin 4.5911005569
MESH:D005234 Fatty Liver Cyclosporine 7.7719224547
MESH:D005234 Fatty Liver Zidovudine 7.7718299183
MESH:D005334 Fever Indomethacin 4.0611852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.8310962813
MESH:D005355 Fibrosis Cyclosporine 8.6812639820 12168785
MESH:D005355 Fibrosis Indomethacin 8.6817994277
MESH:D005499 Folliculitis Indomethacin 5.1111298111
MESH:D005756 Gastritis Indomethacin 4.6915046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D005909 Glioblastoma Genistein 7.2716598420
MESH:D005909 Glioblastoma Indomethacin 7.2712870263
MESH:D005910 Glioma Indomethacin 3.2018371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.2311849393
MESH:D006073 Gout Indomethacin 5.2911248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.7015482327
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9516080930
MESH:D006333 Heart Failure Selenium 3.0317162251
MESH:D006402 Hematologic Diseases Zidovudine 4.6512579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.5115633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.6215135802
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6816490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D015658 HIV Infections beta Carotene 7.0516960176
MESH:D015658 HIV Infections Zidovudine 7.0511141242 11698656 17358032 20032539 11363243
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6917440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.1012676792
MESH:D019584 Hot Flashes Estradiol 9.8617088409
MESH:D019584 Hot Flashes Vitamin E 9.8614716179
MESH:D006930 Hyperalgesia Indomethacin 3.7212727271
MESH:D034321 Hyperamylasemia Indomethacin 5.6617883296
MESH:D006940 Hyperemia Indomethacin 4.9412524144
MESH:D006949 Hyperlipidemias Indomethacin 4.1017546600
MESH:D006973 Hypertension Cyclosporine 2.0710903974
MESH:D007077 Ileal Diseases Indomethacin 4.9718306037 10574470
MESH:D007079 Ileitis Indomethacin 5.2910651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.3216133044
MESH:D007248 Infertility, Male sodium arsenite 2.9415346721 12646999
MESH:D007249 Inflammation Indomethacin 2.957812673 3291741 12568917
MESH:D007251 Influenza, Human Selenium 10.7716624496
MESH:D007251 Influenza, Human Vitamin E 10.7716624496
MESH:D007333 Insulin Resistance bisphenol A 7.2916393666
MESH:D007333 Insulin Resistance Estradiol 7.2916393666 16627594
MESH:D007410 Intestinal Diseases Indomethacin 4.2617329856 18236018 11713966 17994277 15831440 11855677 11686837 10210152 15610444
MESH:D019586 Intracranial Hypertension Indomethacin 5.3215241188
MESH:D007579 Jejunal Diseases Indomethacin 4.9710574470 18306037 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Cyclosporine 18.668314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 18.6615618244
MESH:D007674 Kidney Diseases Indomethacin 18.6617190690
MESH:D007674 Kidney Diseases sodium arsenite 18.6620008137
MESH:D007674 Kidney Diseases Vitamin E 18.6612488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8216518626
MESH:D007680 Kidney Neoplasms Cyclosporine 12.1512371664
MESH:D007680 Kidney Neoplasms Estradiol 12.1515610895
MESH:D007680 Kidney Neoplasms Zidovudine 12.1512579204
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.8512228301 10320625 11703811
MESH:D007938 Leukemia Genistein 2.9918980019 17468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.3520370541
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.8710785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6218360721
MESH:D007964 Leukocytosis Indomethacin 5.3216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.6617980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.6611479899
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 6.6917481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.6917823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.6918194892
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.6916169303
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.6015890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms sodium arsenite 4.6016712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.338603461
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 6.3317113696
MESH:D008171 Lung Diseases Acetylcysteine 12.2012815614
MESH:D008171 Lung Diseases sodium arsenite 12.2019095001
MESH:D008171 Lung Diseases Vitamin E 12.2016863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.6014755239
MESH:D008175 Lung Neoplasms beta Carotene 10.6016401635
MESH:D008175 Lung Neoplasms Indomethacin 10.6011053908 16537180 11497255
MESH:D008175 Lung Neoplasms sodium arsenite 10.6019931552 17077188 16712894 17306315 15276417
MESH:D008175 Lung Neoplasms vanadium pentoxide 10.6012376484
MESH:D008175 Lung Neoplasms Vitamin E 10.6011062179
MESH:D008175 Lung Neoplasms Zidovudine 10.6018800350
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.7511807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.7514578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.7515318939
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D008545 Melanoma epigallocatechin gallate 3.6917992120 11746506
MESH:D008545 Melanoma sodium arsenite 3.6919082730 16487513
MESH:D008654 Mesothelioma Selenium 2.7715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.7817358032
MESH:D008881 Migraine Disorders Indomethacin 3.6311903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.9412636206
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.4317962980
MESH:D009203 Myocardial Infarction Genistein 2.8317141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.3417141266
MESH:D009362 Neoplasm Metastasis Acetylcysteine 6.2414720322
MESH:D009362 Neoplasm Metastasis Indomethacin 6.2416537180 11239499 11053908
MESH:D009369 Neoplasms beta Carotene 5.4617051425
MESH:D009369 Neoplasms sodium arsenite 5.4611559025
MESH:D009374 Neoplasms, Experimental Indomethacin 9.0615625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.0620056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2318481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 16.1016427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 16.1016427766 11399458
MESH:D009421 Nervous System Malformations Genistein 16.1016427766
MESH:D009436 Neural Tube Defects Acetylcysteine 7.5219446573
MESH:D009436 Neural Tube Defects sodium arsenite 7.5212854658
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.8812349958
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.116374098
MESH:D010003 Osteoarthritis Indomethacin 3.637009135
MESH:D010024 Osteoporosis Genistein 3.2119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0216169203
MESH:D010049 Ovarian Diseases bisphenol A 4.9311985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.7919401270
MESH:D010051 Ovarian Neoplasms Genistein 7.7919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.7915276417 17306315
MESH:D010146 Pain Indomethacin 3.413291741 13679232 17627676 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.6218702446 12538197
MESH:D010195 Pancreatitis Indomethacin 3.8617883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.6616537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.0612349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.6611903285
MESH:D010437 Peptic Ulcer Indomethacin 5.0911148446
MESH:D010518 Periodontitis Indomethacin 4.8617225004
MESH:D010954 Plasmacytoma Selenium 4.8315087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.1612371664
MESH:D047928 Premature Birth Indomethacin 5.0617000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.8910548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.3520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.3520887781
MESH:D011471 Prostatic Neoplasms AGN 194204 1.8916000583
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8915378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D011507 Proteinuria Indomethacin 4.1011849393
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7210548101
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.4612210543
MESH:D012871 Skin Diseases Vitamin E 2.4218709164
MESH:D012878 Skin Neoplasms sodium arsenite 2.6719524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7412854658
MESH:D013272 Stomach Diseases beta Carotene 10.4517638125
MESH:D013272 Stomach Diseases Indomethacin 10.4517160473 10192188 10215738 18545984 17207306 18209964 10486359 17638125 15038085 16113693 15472012 16184426 16280098
MESH:D013274 Stomach Neoplasms Indomethacin 2.8715609394
MESH:D013274 Stomach Neoplasms Zidovudine 2.8717696246
MESH:D013276 Stomach Ulcer Acetylcysteine 12.0117918041
MESH:D013276 Stomach Ulcer beta Carotene 12.0112500499
MESH:D013276 Stomach Ulcer Indomethacin 12.0117918041 12500499 15138204 18209962 12077510 18726076 17135157 12467913 17895592 11523592 16755016 18237397 17627676 18193104 18431645 17654042 10878458 11145282 16631530 16934674 17977527 12787963 10750652 12498302 16397915 1323529 11906479 10423059 18543354 16252198 11729361 14567935 18087811 15255614 16150113 18181030 11595415 16169175 18299717 17657623 15104355 11595431
MESH:D020521 Stroke Vitamin E 3.4716517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.9216684133 16045194
MESH:D013964 Thyroid Neoplasms Indomethacin 3.5311352223 14736730 18791128
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D014456 Ulcer Indomethacin 4.8317380554 10574470
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.4816712894 16452187 17306315 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7111813266
MESH:D014591 Uterine Diseases bisphenol A 4.9514652134
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.6912579204
MESH:D014652 Vascular Diseases sodium arsenite 4.3617056641
MESH:D014839 Vomiting Indomethacin 4.6911897121
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28596
    • No data
    No data
    Releated drug ID Related drug Name
    PA450037interferon beta-1a
    PA450039interferon beta-1b
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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