AutismKB 2.0

Annotation Detail for GBP2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GBP2 ( - )
Gene Full Name: guanylate binding protein 2, interferon-inducible
Band: 1p22.2
Quick LinksEntrez ID:2634; OMIM: 600412; Uniprot ID:GBP2_HUMAN; ENSEMBL ID: ENSG00000162645; HGNC ID: 4183
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GBP2 mRNAincreases expression 19933214
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GBP2 mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of GBP2 mRNA]affects expression|affects reaction 19414516
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of GBP2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen results in increased expression of GBP2 mRNAincreases expression 17202762
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GBP2 mRNA]affects expression|affects reaction 19414516
D012436 S-Adenosylmethionine S-Adenosylmethionine results in decreased expression of GBP2 mRNAdecreases expression 18098314
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GBP2 proteinaffects expression 20106945
C430898 AGN 194204 AGN 194204 results in decreased expression of GBP2 mRNAdecreases expression 16339527
D000638 Amiodarone Amiodarone results in increased expression of GBP2 mRNAincreases expression 19774075
C015001 arsenite arsenite results in decreased expression of GBP2 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of GBP2 mRNA]affects reaction|decreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GBP2 mRNAincreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GBP2 mRNAincreases expression 14729362
15003993
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GBP2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of GBP2 mRNAdecreases expression 20106945
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GBP2 mRNAaffects cotreatment|decreases expression 16054899
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of GBP2 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in decreased expression of GBP2 mRNAdecreases expression 14664709
D004958 Estradiol Estradiol results in increased expression of GBP2 mRNAincreases expression 15289156
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of GBP2 mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of GBP2 mRNA]decreases reaction|increases expression 12072388
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of GBP2 mRNAaffects cotreatment|increases expression 17347304
D019833 Genistein Genistein results in increased expression of GBP2 mRNAincreases expression 15289156
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GBP2 mRNAaffects cotreatment|decreases expression 16054899
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of GBP2 mRNAincreases expression 17412507
C008493 methylselenic acid methylselenic acid results in increased expression of GBP2 mRNAincreases expression 18548127
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of GBP2 mRNAincreases expression 17616710
D010126 Ozone Ozone results in decreased expression of GBP2 mRNAdecreases expression 17095637
C006253 pirinixic acid pirinixic acid results in decreased expression of GBP2 mRNAdecreases expression 17426115
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GBP2 mRNAaffects cotreatment|decreases expression 16054899
C017947 sodium arsenite sodium arsenite results in decreased expression of GBP2 mRNAdecreases expression 12377979
C004648 testosterone enanthate testosterone enanthate affects the expression of GBP2 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GBP2 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GBP2 mRNAincreases expression 19933214
D014212 Tretinoin Tretinoin results in increased expression of GBP2 mRNAincreases expression 16249480
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of GBP2 mRNAincreases expression 17982090
D014520 Urethane Urethane results in decreased expression of GBP2 mRNAdecreases expression 16289808
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 12.367525203
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.3618926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.3611752688 15322242 14514962
MESH:D000138 Acidosis Ethanol 4.1611192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 15.9020127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 15.9011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.9014692618
MESH:D000230 Adenocarcinoma Genistein 15.9011473722
MESH:D000230 Adenocarcinoma Methylnitrosourea 15.9015688392 15113128
MESH:D000230 Adenocarcinoma Urethane 15.9018316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.3615814487
MESH:D000236 Adenoma Benzo(a)pyrene 6.396695378
MESH:D000236 Adenoma Urethane 6.3910822126 10530776 16926031 11497255 6695378 17093202 17195641
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5616712894 17306315
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9715451040 15451039
MESH:D000505 Alopecia Tretinoin 3.3515955085
MESH:D000544 Alzheimer Disease Ozone 4.2015513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.2019621015
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1615469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6511748828
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D000853 Anophthalmos Ethanol 4.4915513904
MESH:D001008 Anxiety Disorders Ethanol 3.7411141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7419183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5118057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1311256880
MESH:D001169 Arthritis, Experimental Dexamethasone 11.0617659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.0615885639
MESH:D001169 Arthritis, Experimental Tretinoin 11.0616412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.3715570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.3716292516
MESH:D001249 Asthma Ozone 4.5817854713 16373670
MESH:D001249 Asthma Tretinoin 4.5816456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.6518651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 2.4518445737
MESH:D001321 Autistic Disorder S-Adenosylmethionine 2.4516917939 19056591
MESH:D001471 Barrett Esophagus Tretinoin 4.0816935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 19.4619483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.4612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 19.4616197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.5320146248 17474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.5317129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 3.5312948864 16675129 14630087 17261762 17018787 18497071 17289903 19861407
MESH:D001943 Breast Neoplasms Genistein 3.5316873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylnitrosourea 3.5316253758 14633655 11306469
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5320435547
MESH:D001943 Breast Neoplasms Tretinoin 3.5316166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4117626835 18417511 19059883 18315731 14754758 15516495 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2516813970
MESH:D002056 Burns Ethanol 4.3216374292
MESH:D002100 Cachexia Ozone 4.4016183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4516192424 15721981 3786805 15700767 18705752 16227642 16124888 10355542 16097048 15673190 16050911 16011737
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8116168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 18.673084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 18.6721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 18.6718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 18.6715948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 18.6716924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 18.6718788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Genistein 18.6716924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.6715276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 18.671917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.8820419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.8818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.8816096774 16051514
MESH:D006332 Cardiomegaly Ethanol 6.2119332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2118670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7715710769 19225199
MESH:D002318 Cardiovascular Diseases Genistein 3.0716332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7418974383
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 16.0614694615
MESH:D002386 Cataract Acetaminophen 16.0610977129
MESH:D002386 Cataract Methylnitrosourea 16.0612484553
MESH:D002386 Cataract Tretinoin 16.0617460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.1412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.1418566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 14.142727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.1419524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8816835633
MESH:D002779 Cholestasis Cyclosporine 11.8919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.8917681005 15861022 16919318 17333356 16105132 17110522 11677210
MESH:D002779 Cholestasis pirinixic acid 11.8919176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8116461808
MESH:D002971 Cleft Lip Ethanol 3.4115513904
MESH:D002972 Cleft Palate Ethanol 12.9215513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 12.9216354765 8697196 15668235 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 12.929407595
MESH:D002972 Cleft Palate Urethane 12.9212810352
MESH:D003092 Colitis Tretinoin 8.6717035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 8.6717991707 16804969 18023891 16782535 16867261 18200517 17936198 16474422 11698051
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3217276891
MESH:D003110 Colonic Neoplasms arsenite 5.5315037631
MESH:D003110 Colonic Neoplasms Dexamethasone 5.5315824018
MESH:D003110 Colonic Neoplasms Genistein 5.5317182828
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.2415095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.0917728286
MESH:D019465 Craniofacial Abnormalities Ethanol 5.0915513904 15451039 10194807 19302082 15451040 11873399 11198716
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0915322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.099211117 10589399 8800419 16925845 9142499 17551590 14991402 9664655 9224671 9125849
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2316002989 12952375
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0912438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0217446233
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.6616647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 6.6612642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1319279558
MESH:D003967 Diarrhea Dexamethasone 3.387237001
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 13.8321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.8315619225 10915739 19923254 19416960 2444490 18071297 10663392 16485898 12153990 11834606 16393943 11287661 18713872 19085960 19420014 17906064 10774834 16109766 12594235 12392966 19164858 11461765 11529661 12705907 12540782 17562736 14550746 17522070 11739529 19370779 11743745 16177239 16081117 14725611 15968718 16781746 19739265 14986274 11421492 12958197 16227642
MESH:D056486 Drug-Induced Liver Injury Amiodarone 13.8318218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.8319336974 15998439 7120509 6884620 3732212 10092053 3786805 6623471 17522070 15027814 2869522 7179309 10915739 11566570 19085960 9327722 15968718 4309450 16177239 7440962 16227642 21278145
MESH:D056486 Drug-Induced Liver Injury Ethanol 13.8311566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.8320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5111462148
MESH:D004485 Eczema Dexamethasone 4.1412438553
MESH:D004487 Edema Dexamethasone 13.9919703484
MESH:D004487 Edema pirinixic acid 13.9912083418
MESH:D004487 Edema rosiglitazone 13.9912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.9912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.7915322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.7918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8712538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.7616402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.7616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 15.9715700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 15.9719148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 15.9711473722
MESH:D016889 Endometrial Neoplasms Tretinoin 15.9716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.739294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.8016530937
MESH:D004938 Esophageal Neoplasms Ethanol 6.8016704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.8015878914 15547721 15264214 15150132 15547733 16805852 16510608 16704527 15623463
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0011564622
MESH:D005124 Eye Abnormalities Tretinoin 8.0016938888 9664655
MESH:D005234 Fatty Liver Amiodarone 43.9214986274
MESH:D005234 Fatty Liver arsenite 43.9218296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 43.9217595544 19224547 15959796 16045604 12631006 61145 12795759 16239168
MESH:D005234 Fatty Liver Cyclosporine 43.9219224547
MESH:D005234 Fatty Liver Ethanol 43.9216409862 18620774 19236843
MESH:D005234 Fatty Liver Ethinyl Estradiol 43.9215345470
MESH:D005234 Fatty Liver Fish Oils 43.9218620774
MESH:D005234 Fatty Liver pirinixic acid 43.9220131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 43.9219196556
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3217920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.4515751030 16513791 16534752 16611131 16002989
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9615451040 16946407 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1211858732
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.8911555667
MESH:D005355 Fibrosis arsenite 30.1918296743
MESH:D005355 Fibrosis Carbon Tetrachloride 30.1918705752
MESH:D005355 Fibrosis Cyclosporine 30.1912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 30.1920067830
MESH:D005355 Fibrosis Tretinoin 30.1917994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 30.1917994277
MESH:D005756 Gastritis Acetaminophen 9.9716983495
MESH:D005756 Gastritis Ethanol 9.9715046732
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.6816452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.6816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.888708960
MESH:D005909 Glioblastoma Genistein 6.4716598420
MESH:D005909 Glioblastoma Tretinoin 6.4717312396
MESH:D005910 Glioma Methylnitrosourea 3.439825942
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8116084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.0320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.0310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.039664655 14991402
MESH:D006331 Heart Diseases Urethane 4.0116046796
MESH:D006333 Heart Failure pirinixic acid 2.3320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2719900420 19110552
MESH:D006529 Hepatomegaly Amiodarone 12.4915265979
MESH:D006529 Hepatomegaly pirinixic acid 12.4918467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.4912621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.957520565
MESH:D006558 Herpes Genitalis Estradiol 4.6915709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.4017440010
MESH:D006689 Hodgkin Disease sodium arsenite 2.8812676792
MESH:D019584 Hot Flashes Estradiol 3.4117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.708697196 16959395 18606429 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 16.5116870215
MESH:D006930 Hyperalgesia Ethanol 16.5118783367
MESH:D006930 Hyperalgesia rosiglitazone 16.5112083418
MESH:D006930 Hyperalgesia Tretinoin 16.5116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1916899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.578137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2416778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8920558911
MESH:D006949 Hyperlipidemias Fish Oils 4.4415752949
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1014722030 12960047
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.1611484837
MESH:D006973 Hypertension Cyclosporine 7.8010903974
MESH:D006973 Hypertension Dexamethasone 7.8017042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.8018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7515338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.1416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.1416569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.1817991464 18020914
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.1018306037
MESH:D007246 Infertility Diethylstilbestrol 4.0315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.9917937319
MESH:D007248 Infertility, Male Methylnitrosourea 9.997193160
MESH:D007248 Infertility, Male sodium arsenite 9.9912646999 15346721
MESH:D007249 Inflammation Dexamethasone 7.3911099482 8960868
MESH:D007249 Inflammation rosiglitazone 7.3912083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.3912200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.4418200517
MESH:D007333 Insulin Resistance Estradiol 11.1016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.1016306350
MESH:D007333 Insulin Resistance rosiglitazone 11.1016306350
MESH:D007410 Intestinal Diseases Tretinoin 8.8817994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 8.8817994277
MESH:D007569 Jaw Abnormalities Ethanol 15.4215513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 15.4216580747
MESH:D007569 Jaw Abnormalities Tretinoin 15.4215992940 17551590
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.1018306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0915604871
MESH:D007674 Kidney Diseases Acetaminophen 12.7815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 12.788314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 12.7815618244
MESH:D007674 Kidney Diseases sodium arsenite 12.7820008137
MESH:D007680 Kidney Neoplasms Cyclosporine 10.8512371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 10.8515003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 10.8515610895
MESH:D007859 Learning Disorders Diethylstilbestrol 8.6817184923
MESH:D007859 Learning Disorders Ethanol 8.6815451040
MESH:D007938 Leukemia Genistein 5.8318980019 17468513
MESH:D007938 Leukemia Tretinoin 5.8317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0216294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9317506722 19642359 19225113 17107899 19029980 17649720 12679006 17339181 17217047 16891316 17368321 19035177 16140955 17361223 16935935 9834237 17301526 19075265 16331271 16823087 15748426 16788101 16766008 17712046 17294898
MESH:D017880 Limb Deformities, Congenital Ethanol 12.4117676605
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 12.4115526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 12.419224671
MESH:D008064 Lipidoses Amiodarone 3.2717567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 10.0618296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.0617334410 16943688 17157831 11408273 16239168 16221502 21278145 17174718 11903743
MESH:D008103 Liver Cirrhosis Ethanol 10.0615289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7618295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 17.2217805973 14512876 14748882 15057751 18054572 18418968 12445418 16097048 17761835 12666154 16638106 17698563 17922224 18187930 15370692 12609069 18210741 15650968 14716496 17525996 16248980 20821823 15931870 15925388 18395914 18156304 15673190 17900296 18472094 16011737 18277467 15876570 16015684 10355542 12632514 17721639 12649538 15893842 17708605 12667390 17481882 17944888 18412020 11481614 18472332 12586293 15338365 16027843 17869086 17640975 15730626 18429990 16136751 18263696 17557913 12632512 15996030 18481824 17714472 14716833 15818738 12389079 12958196 12445421 12741479 18006644 12898905 15052691 18376398 18705752 12546737 17976157 18251166 18205269 18166357 17823541 17766677 17631135 16116963 14724832 15959796 18317297 18339082 15362042 18395095 17565644 18420326 13678700 16033810 15123356 14620537 18279442 16192424
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 17.2216718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 17.2214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 17.2218166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 17.2217823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 17.2215474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 17.2217347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental S-Adenosylmethionine 17.2215983038
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 17.2212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 17.2218397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.5819460945 16611625 19014921 16610002 19784758 12587719 12969438 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.5815830285 15720792 16246199 16964402 17285989
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3217347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.4316871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.4316899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 23.579163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 23.5720195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 23.5719294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 23.5715890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 23.5716377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 23.5716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.5716984957
MESH:D008113 Liver Neoplasms Urethane 23.5716391232 17559639 17093202
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 8.578603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.5715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.5712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3217391786 15350150 11989578
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.1316080182
MESH:D008171 Lung Diseases Amiodarone 11.0712587719
MESH:D008171 Lung Diseases Ozone 11.078266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 11.0719095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1318516814
MESH:D055370 Lung Injury Ozone 3.5220417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 14.4714755239
MESH:D008175 Lung Neoplasms arsenite 14.4716809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.4717053015 20464547 20869020 18569708 6695378 18816296 20064080 20135361 18520028
MESH:D008175 Lung Neoplasms Dexamethasone 14.4711195469 15824018
MESH:D008175 Lung Neoplasms Methylnitrosourea 14.4718062963
MESH:D008175 Lung Neoplasms Ozone 14.477614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 14.4716712894 15276417 17306315 19931552 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.4711884234 19555203
MESH:D008175 Lung Neoplasms Urethane 14.4717255336 15166089 7750092 12957351 11307925 16289808 14587096 11893704 12117781 12765245 10779650 15902970 11246140 10997738 11074608 10822126 16007126 12466968 11992545 6695378 11497255 16926031 17195641 16204055 16788158 11323394 17093202 11807781 11552296 11544531 16337739 16391232 11062179 10530776 15136453
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8115166399
MESH:D008223 Lymphoma Diethylstilbestrol 7.1515700306
MESH:D008223 Lymphoma Methylnitrosourea 7.1511418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.4614633661
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1716002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.5516891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.5514578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 12.5515113128 14999141 11751437 16051031 10767621 15688392 11807958 19196723 16619500 17020996 15313902 17131329 16827153 14633655 12931682 10838139 16944150
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 12.5516827153
MESH:D020149 Manganese Poisoning Estradiol 4.1419453300
MESH:D008527 Medulloblastoma Tretinoin 2.6517453147
MESH:D008545 Melanoma sodium arsenite 3.1316487513 19082730
MESH:D008545 Melanoma Tretinoin 3.1316752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2419513568
MESH:D008569 Memory Disorders Ethanol 3.8718411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 4.0916940565
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1017261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4416801185
MESH:D008679 Metaplasia Ozone 4.7610496685
MESH:D020326 Migraine without Aura Cyclic AMP 4.8311304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9316381670
MESH:D009101 Multiple Myeloma Dexamethasone 3.2715744524 15867202 16118317
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009181 Mycoses Amiodarone 4.5617974566 12754197
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.889809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8817596541
MESH:D009203 Myocardial Infarction Genistein 5.1917141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.6716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.6717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.6716411023
MESH:D009369 Neoplasms Benzo(a)pyrene 21.4011141357
MESH:D009369 Neoplasms Diethylstilbestrol 21.4015313581
MESH:D009369 Neoplasms Methylnitrosourea 21.4015533788
MESH:D009369 Neoplasms pirinixic acid 21.4017405874
MESH:D009369 Neoplasms sodium arsenite 21.4011559025
MESH:D009369 Neoplasms Tretinoin 21.4016594593 16946489
MESH:D009369 Neoplasms Urethane 21.4015625555
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 13.5712696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 13.5720056578
MESH:D009374 Neoplasms, Experimental Urethane 13.5715582191
MESH:D009389 Neovascularization, Pathologic arsenite 9.0215738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.0217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0019348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 27.3011399458
MESH:D009421 Nervous System Malformations Estradiol 27.3011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 27.3016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 27.3014600291
MESH:D009421 Nervous System Malformations Tretinoin 27.309125849
MESH:D009436 Neural Tube Defects sodium arsenite 6.5712854658
MESH:D009436 Neural Tube Defects Tretinoin 6.579142499
MESH:D009442 Neurilemmoma Methylnitrosourea 5.1511555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6018514411
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 3.8014694615
MESH:D010024 Osteoporosis Genistein 3.0419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7716169203
MESH:D010051 Ovarian Neoplasms Estradiol 13.7719401270
MESH:D010051 Ovarian Neoplasms Genistein 13.7719005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.7717306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 13.7716936753
MESH:D010051 Ovarian Neoplasms Urethane 13.7716391232
MESH:D010146 Pain Acetaminophen 5.6916870215
MESH:D010146 Pain Tretinoin 5.6916870215
MESH:D010190 Pancreatic Neoplasms Ethanol 8.0512384795
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 8.0516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.0515976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.8917698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D010538 Peritonitis Ozone 3.8016369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 11.0216977796 15687265
MESH:D010911 Pituitary Neoplasms Urethane 11.0216391232
MESH:D011014 Pneumonia Ozone 4.0518929643 18007984 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2418163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9412371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3521297632
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.4417184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4411222880 11118676 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5820887781
MESH:D011471 Prostatic Neoplasms AGN 194204 2.3716000583
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3717292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.3717136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.3716740699
MESH:D011471 Prostatic Neoplasms Genistein 2.3715256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.3715682402 12376480
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.3716205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3716039940
MESH:D011507 Proteinuria Tretinoin 3.2916636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9816919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011625 Pterygium Tretinoin 4.4516723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7212490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.2219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7118379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.1618172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.1511555667
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7916283617 16116481
MESH:D012640 Seizures Ethanol 2.959754883
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7418724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 20.3410029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 20.3418572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 20.348532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 20.3416192470
MESH:D012878 Skin Neoplasms Tretinoin 20.3416467112
MESH:D012878 Skin Neoplasms Urethane 20.3411807781
MESH:D013088 Spermatocele Diethylstilbestrol 10.5616709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.5616709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5412854658
MESH:D013272 Stomach Diseases Dexamethasone 3.9815472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.002093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 6.0018456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 6.0016257854 15930296 18593901
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 6.0017575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 6.0017261132
MESH:D013276 Stomach Ulcer Amiodarone 10.4218087811
MESH:D013276 Stomach Ulcer Dexamethasone 10.4215138204
MESH:D013276 Stomach Ulcer Ethanol 10.4217189318 11906479 9562338 17918041 9211565 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.969754883
MESH:D013610 Tachycardia Amiodarone 3.9711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8719225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.8911418001
MESH:D013959 Thyroid Diseases Amiodarone 10.9019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9012697716
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 6.677505956 3078959
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6716026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.5318020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.3419048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4916051514
MESH:D016171 Torsades de Pointes Amiodarone 3.8511989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.0216040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.5417053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 7.5416712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.5416712894 16452187 11723127 17306315
MESH:D014581 Urticaria Acetaminophen 2.6710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.1816175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.1811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.1816129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.4015809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.4014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2616752155
MESH:D014605 Uveitis Cyclosporine 10.611336536
MESH:D014605 Uveitis Dexamethasone 10.611336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1016002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.0817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D019043 Vascular Neoplasms Urethane 5.5710620525
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2414671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
MESH:D009396 Wilms Tumor Tretinoin 3.6816287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0917120751
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28597
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved