AutismKB 2.0

Annotation Detail for HSPB8


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HSPB8 ( CMT2L,DHMN2,E2IG1,H11,HMN2,HMN2A,HSP22 )
Gene Full Name: heat shock 22kDa protein 8
Band: 12q24.23
Quick LinksEntrez ID:26353; OMIM: 608014; Uniprot ID:HSPB8_HUMAN; ENSEMBL ID: ENSG00000152137; HGNC ID: 30171
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1770Melanoma
1781Rheumatoid arthritis
1944Breast cancer
1953Nervous system disease
1963Amyloidosis
No data
No data
Desease Name
Charcot-Marie-Tooth disease, axonal, type 2L
Neuropathy, distal hereditary motor, type IIA
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HSPB8 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of HSPB8 mRNAaffects expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of HSPB8 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of HSPB8 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of HSPB8 mRNAincreases expression 17202762
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of HSPB8 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HSPB8 mRNAaffects expression 16483693
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one promotes the reaction [Ozone results in increased expression of HSPB8 mRNA]increases expression|increases reaction 17460151
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HSPB8 mRNAincreases expression 18687144
D016589 Astemizole Astemizole results in increased expression of HSPB8 mRNAincreases expression 20221588
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of HSPB8 mRNAincreases expression 19737606
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HSPB8 mRNAincreases expression 20106945
C006780 bisphenol A bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of HSPB8 mRNA]decreases reaction|increases expression 19228888
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of HSPB8 mRNAincreases expression 14729362
D016572 Cyclosporine Cyclosporine results in increased expression of HSPB8 mRNAincreases expression 20106945
C044101 endotoxin, Escherichia coli endotoxin, Escherichia coli results in increased expression of HSPB8 mRNAincreases expression 15919760
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HSPB8 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of HSPB8 mRNAincreases expression 20106945
19619570
D005472 Fluorouracil Fluorouracil results in increased expression of HSPB8 mRNAincreases expression 16557594
D017313 Fenretinide Fenretinide results in increased expression of HSPB8 mRNAincreases expression 16671099
C029424 hydrazine hydrazine results in increased expression of HSPB8 mRNAincreases expression 15282401
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of HSPB8 mRNAincreases expression 14729362
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of HSPB8 mRNAincreases expression 15919760
C002950 methylformamide methylformamide affects the expression of HSPB8 mRNAaffects expression 17040096
C002950 methylformamide methylformamide analog affects the expression of HSPB8 mRNAaffects expression 17040096
D010126 Ozone anthra(1,9-cd)pyrazol-6(2H)-one promotes the reaction [Ozone results in increased expression of HSPB8 mRNA]increases expression|increases reaction 17460151
C006253 pirinixic acid pirinixic acid results in increased expression of HSPB8 mRNAincreases expression 18445702
C031280 pyrazole pyrazole results in increased expression of HSPB8 mRNAincreases expression 17945193
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of HSPB8 mRNAaffects cotreatment|decreases expression 19059307
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of HSPB8 mRNAincreases expression 16678137
C017947 sodium arsenite sodium arsenite results in increased expression of HSPB8 mRNAincreases expression 16014739
D014284 Triiodothyronine bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of HSPB8 mRNA]decreases reaction|increases expression 19228888
D014284 Triiodothyronine Triiodothyronine results in increased expression of HSPB8 mRNAincreases expression 19228888
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of HSPB8 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HSPB8 mRNAdecreases expression 16443690
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HSPB8 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HSPB8 mRNAincreases expression 20106945
19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2514745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 7.507525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.1411850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.1418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.5620127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.5611473722
MESH:D000230 Adenocarcinoma Fenretinide 9.5610697514
MESH:D000230 Adenocarcinoma Fluorouracil 9.5617638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.203712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.206695378
MESH:D000236 Adenoma beta-Naphthoflavone 10.2019389873
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6016712894 17306315
MESH:D000419 Albuminuria Raloxifene 4.3117308373 17451421
MESH:D000544 Alzheimer Disease Ozone 4.1315513908
MESH:D000544 Alzheimer Disease Raloxifene 4.1315800139
MESH:D000740 Anemia Fluorouracil 7.8317963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.8311748828
MESH:D000799 Angioedema Acetaminophen 11.0310982225
MESH:D000799 Angioedema Astemizole 11.032883202
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7819183758
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4915570426
MESH:D001249 Asthma Ozone 2.5517854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.721440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.8919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001862 Bone Resorption bisphenol A 3.6011985600
MESH:D001930 Brain Injuries Raloxifene 4.1916580743
MESH:D001932 Brain Neoplasms Fenretinide 4.1016187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.4820146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 4.4817123778
MESH:D001943 Breast Neoplasms Estradiol 4.4816675129 17289903 19861407 12948864 17261762 18497071 17018787 14630087
MESH:D001943 Breast Neoplasms Fenretinide 4.4816601279
MESH:D001943 Breast Neoplasms Fluorouracil 4.4819217205 16557594 15136595 18357371 16110121 16595493 18608205
MESH:D001943 Breast Neoplasms Raloxifene 4.4816912660 17595753 17893378 17952589 15758505 15775269 15572757 16837676 17440819 17261762 17242785 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 4.4818425577 18629630 19410462 19142967 21138602 18351453 17242785 19221464 19200415 19011961 19066611 17893378 16873071 16202921 19059307 19155303 20859285 15668708 19289846 19189212 16818667 18815881 19487384 19084267 19288272 11161223 17049068 21152245 20005174 18855134 18997820 19189210 18821012 20135344 18984771 17261762 17440819 20544844 20390343 19115204 20065188 15565566 16273361 19244106 19103187
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.4820435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4518315731 17626835 15516495 19059883 18417511 16777450 14754758
MESH:D002100 Cachexia Ozone 4.4416183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3716051944
MESH:D002277 Carcinoma Fluorouracil 7.4217121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 21.8616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 21.867296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 21.863084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 21.8621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 21.8619418558
MESH:D006528 Carcinoma, Hepatocellular Estradiol 21.8616924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 21.8616270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 21.8617971768 18930000 17045692 17088986 16332177 16799960
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 21.8617306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 21.8616924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.6917123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.037296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.0318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.0820419170
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 10.0816274795
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.0816757204 18986760 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.0818572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.6517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.6517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.9116936243
MESH:D002318 Cardiovascular Diseases Raloxifene 6.9115775269
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.8514694615
MESH:D002386 Cataract Acetaminophen 6.8510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.367505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.3612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.3618566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.3619524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.1816154183
OMIM:608673 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2L marker/mechanism
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.139022650 19486331
MESH:D002779 Cholestasis Cyclosporine 12.1319486331
MESH:D002779 Cholestasis pirinixic acid 12.1319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9816354765 15340226 15668235 8697196 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.3315800139
MESH:D003110 Colonic Neoplasms Fluorouracil 2.1915001691 16340194 16510598 18772588 17725105 17018589 17172411 17169374 17016597 17287894
MESH:D015179 Colorectal Neoplasms Fenretinide 2.7717273769
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7717695437 15289873 18383874 16391804 18509181 14970324 20501625 18448328 17454858 16524972 16282729 18288408 18802399 18949393 17401013 17255274 15148649 17094418 16303861 17016601 16331619 17594712
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.3715095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.3714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2410048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7318551238
MESH:D007644 Darier Disease Fluorouracil 4.5016733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9217474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5314531868 8970840 11906362 11298694 18759878 2524372 12868966 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.222952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6017107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.6019279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.6017308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.6019279558
MESH:D004244 Dizziness Astemizole 6.173105558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.0521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.0518692083 6482804 18289764 1440618 9022650 16192314 6679447 11289319 8291058 7440962 9653073 18648102 9328219
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 14.0521346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.0519164858 16109766 12594235 19739265 17562736 11421492 19370779 14725611 16485898 16177239 16393943 17906064 12153990 11461765 14550746 10663392 15619225 14986274 12540782 19085960 19923254 11287661 2444490 11834606 19420014 15968718 18713872 16227642 11739529 10915739 12392966 16081117 11743745 16781746 10774834 12705907 11529661 17522070 18071297 19416960 12958197
MESH:D056486 Drug-Induced Liver Injury pyrazole 14.0512499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.0520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5511462148
MESH:D004487 Edema pirinixic acid 9.9212083418
MESH:D004487 Edema Raloxifene 9.9215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.9212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.3115845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3119031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.7518566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.7517893378 19155303 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.779294722 10568697
MESH:D019446 Endotoxemia endotoxin, Escherichia coli 10.0717637181 18509659
MESH:D019446 Endotoxemia Lipopolysaccharides 10.0715821434 17637181 15328337
MESH:D004802 Eosinophilia Astemizole 4.521355641
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.763581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.7616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.7615173087 16481741 16337965 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005234 Fatty Liver Cyclosporine 16.6119224547
MESH:D005234 Fatty Liver pirinixic acid 16.6119236843 20131406
MESH:D005234 Fatty Liver Raloxifene 16.6117473493
MESH:D005234 Fatty Liver Tamoxifen 16.6119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005334 Fever endotoxin, Escherichia coli 8.9116997862
MESH:D005334 Fever Lipopolysaccharides 8.919205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.726705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8919069698
MESH:D005355 Fibrosis Cyclosporine 7.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.5220067830
MESH:D005499 Folliculitis Astemizole 5.621671328
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D005909 Glioblastoma Fenretinide 3.7016187019
MESH:D005910 Glioma Fluorouracil 2.7516145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.767505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1915102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9311294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.3311110106
MESH:D006333 Heart Failure pirinixic acid 2.3620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.236705139
MESH:D006529 Hepatomegaly pirinixic acid 7.3019176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3016120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.9112676792
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.758697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.4716870215
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6515034207
MESH:D006973 Hypertension Cyclosporine 7.9010903974
MESH:D006973 Hypertension Raloxifene 7.9017577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.9018850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 2.8015346721 12646999
MESH:D007249 Inflammation Lipopolysaccharides 7.439205823 12878042 17963957 17237260 17255318
MESH:D007249 Inflammation Tamoxifen 7.4319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.4312200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 11.2116393666
MESH:D007333 Insulin Resistance Estradiol 11.2116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.2116306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3617255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.729022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007674 Kidney Diseases Acetaminophen 13.0112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.018314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 13.0115618244
MESH:D007674 Kidney Diseases sodium arsenite 13.0120008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 26.0116705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 26.016582329
MESH:D007680 Kidney Neoplasms Cyclosporine 26.0112371664
MESH:D007680 Kidney Neoplasms Estradiol 26.0115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 26.0116985049
MESH:D007680 Kidney Neoplasms Tamoxifen 26.0118625569
MESH:D007889 Leiomyoma Raloxifene 4.2216973256
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 5.0816972261
MESH:D007970 Leukopenia Lipopolysaccharides 4.4015821434
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7416707609
MESH:D017513 Lichen Nitidus Astemizole 6.172563723
MESH:D008064 Lipidoses Tamoxifen 2.9515342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.019327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.3012878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.3018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3012878042
MESH:D008107 Liver Diseases Acetaminophen 1.5619460945 16611625 12969438 11587558 19014921 12587719 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9817185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 23.939163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 23.9321137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 23.9319389873 21295105
MESH:D008113 Liver Neoplasms Fluorouracil 23.9317045692 16603448 15113037 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 23.9320007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 23.9315276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 23.9316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.9316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.62598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.628603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 12.6218164116
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.6212151625
MESH:D008133 Long QT Syndrome Astemizole 4.3718472280 11989578
MESH:D008171 Lung Diseases Ozone 6.8619066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 6.8619095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 13.5817365036
MESH:D055370 Lung Injury Lipopolysaccharides 13.5821114838
MESH:D055370 Lung Injury Ozone 13.5820417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.0814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.0818569708 20135361 20464547 20064080 18816296 20869020 18520028 17053015 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 10.0815246190
MESH:D008175 Lung Neoplasms Ozone 10.088597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 10.0819931552 15276417 16712894 17077188 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 10.0818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.0811884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5015086387
MESH:D008288 Malaria Astemizole 4.5416816845
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.9716891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 8.9710697514
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.9711731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.6519453300
MESH:D008545 Melanoma Fenretinide 4.8816270382
MESH:D008545 Melanoma sodium arsenite 4.8819082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0716966607 18303189 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D008679 Metaplasia Ozone 4.8110496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2515863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 13.1716381670
MESH:D009062 Mouth Neoplasms Fenretinide 13.1716274795
MESH:D009062 Mouth Neoplasms Fluorouracil 13.1718986760 16757204
MESH:D009101 Multiple Myeloma Raloxifene 3.2316497877
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5116411023
MESH:D009232 Myxoma Raloxifene 5.2516343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5618551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.293581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.2919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 14.1611141357
MESH:D009369 Neoplasms Fenretinide 14.1617353921 15958647
MESH:D009369 Neoplasms Fluorouracil 14.1618600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 14.1617405874
MESH:D009369 Neoplasms sodium arsenite 14.1611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3820056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7019200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0419348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 14.7316427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 14.7316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.7314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.626679447
MESH:D009436 Neural Tube Defects sodium arsenite 6.6212854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6318514411
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.3816303764
OMIM:158590 NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IIA marker/mechanism
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2416436463
MESH:D009759 Nystagmus, Pathologic Astemizole 6.176135121
MESH:D009765 Obesity pirinixic acid 1.7420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.6812819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 13.686482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 13.6814694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.723988306
MESH:D010024 Osteoporosis Raloxifene 3.2117882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9617823083 17893378 15579764 15758505
MESH:D010049 Ovarian Diseases bisphenol A 4.6911985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.4219401270
MESH:D010051 Ovarian Neoplasms Fenretinide 7.4216133793
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.4215276417 17306315
MESH:D010146 Pain Acetaminophen 2.1616870215
MESH:D010190 Pancreatic Neoplasms Fenretinide 5.3015580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.3016500647 16929163 19003803 15113037
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.367296757
MESH:D010212 Papilloma Hydrogen Peroxide 8.3612065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D010538 Peritonitis Ozone 3.8416369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.176228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6010923243
MESH:D011014 Pneumonia Lipopolysaccharides 10.1212224865 11605937
MESH:D011014 Pneumonia Ozone 10.1218007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9812371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.5210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5211399792 11896295 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.6720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.6720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.3816740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.3816740699
MESH:D011471 Prostatic Neoplasms Fenretinide 2.3817024972
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.3819082440 18626508
MESH:D011471 Prostatic Neoplasms Raloxifene 2.3816536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.3815067354
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011629 Puberty, Precocious bisphenol A 4.4910548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9215814490 17365031 17975199 17322281
MESH:D011693 Purpura Raloxifene 5.2515770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7618722050 15538739 16160472 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5410835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.393692021
MESH:D012162 Retinal Degeneration Fenretinide 8.3916303925
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.1310822083
MESH:D012640 Seizures 2,4-dinitrotoluene 2.3418551238
MESH:D012772 Shock, Septic endotoxin, Escherichia coli 5.3418063050
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 20.6510029692 19755658
MESH:D012878 Skin Neoplasms Fenretinide 20.6516467112
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 20.6512065085
MESH:D012878 Skin Neoplasms sodium arsenite 20.6518572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 20.658532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 20.6516192470
MESH:D013088 Spermatocele Tamoxifen 3.9916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5712854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.342093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.3417522103 19015929 18396642 17498489 16424979 19084572 15786421 17172411 16951190 18567086
MESH:D020521 Stroke Raloxifene 3.5916837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.6916045194 16684133
MESH:D013733 Testicular Diseases pyrazole 4.526499806
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9115821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.676587162 6582329 3712494 7505956 1399818
MESH:D013978 Tibial Fractures Estradiol 12.7119048282
MESH:D013978 Tibial Fractures Raloxifene 12.7119048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7316280240
MESH:D016171 Torsades de Pointes Astemizole 4.919583453 8256756
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 22.3116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 22.318074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 22.3117053015
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 22.3116720286
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 22.3117572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 22.3111723127 17306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 22.318653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0210091137
MESH:D014581 Urticaria Acetaminophen 8.1310982225
MESH:D014581 Urticaria Astemizole 8.132568189 2565098 2885854 1976298 3097109 3080510 2147912 2859714 2568013 3134034 1683191 2883202
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 14.5016154183
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.5016803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.5011813266
MESH:D014591 Uterine Diseases bisphenol A 4.7114652134
MESH:D014605 Uveitis Cyclosporine 3.681336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9116837676
MESH:D014717 Vertigo Astemizole 6.173105558
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved