AutismKB 2.0

Annotation Detail for GNL3


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Basic Information Top
Gene Symbol:GNL3 ( C77032,E2IG3,MGC800,NS )
Gene Full Name: guanine nucleotide binding protein-like 3 (nucleolar)
Band: 3p21.1
Quick LinksEntrez ID:26354; OMIM: 608011; Uniprot ID:GNL3_HUMAN; ENSEMBL ID: ENSG00000163938; HGNC ID: 29931
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1841Stomach cancer
2022Liver cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GNL3 mRNAaffects expression 21346803
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of GNL3 mRNAincreases expression 17011747
D000082 Acetaminophen Acetaminophen affects the expression of GNL3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GNL3 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GNL3 mRNAdecreases expression 20382639
19150397
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GNL3 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of GNL3 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GNL3 mRNAaffects cotreatment|affects expression 17602206
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of GNL3 mRNAincreases expression 17011747
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GNL3 mRNAaffects expression 17555576
C009250 sevoflurane sevoflurane affects the expression of GNL3 mRNAaffects expression 15967596
D013629 Tamoxifen Tamoxifen affects the expression of GNL3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GNL3 mRNAdecreases expression 20106945
D014212 Tretinoin Tretinoin results in decreased expression of GNL3 mRNAdecreases expression 16604517
D014635 Valproic Acid Valproic Acid results in decreased expression of GNL3 mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4815322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.488875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma Diethylnitrosamine 2.8710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.2317162532 17620307 18056438 19061943 16434500 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.2316835633
MESH:D000505 Alopecia Tretinoin 3.6415955085
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5215469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.2615885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.2616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3516456186
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518558336 18940202 18316065 20603192 17507914 18396377 18985861 16609825 17688650 18775368 19460635 19232924 17157402 18177632 15238991
MESH:D001471 Barrett Esophagus Tretinoin 4.4416935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.0917594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.0316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.0815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.088888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3417474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.3417129689 15324884
MESH:D001943 Breast Neoplasms Tamoxifen 2.3421152245 20005174 21138602 20135344 19487384 11161223 19289846 18984771 17049068 18351453 17440819 19142967 20859285 15565566 19059307 19189212 18425577 15668708 19103187 19155303 20065188 18629630 17261762 18855134 16818667 20544844 18821012 19084267 17242785 19011961 20390343 16202921 18997820 19189210 19288272 19115204 19410462 17893378 19200415 19244106 16273361 18815881 19066611 19221464 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3416873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6416813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2216168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.4616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.463084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.463581430 10672840 17761372 20514400 19335982 17173139 20007298 17138121 16698587 16830150 17162532 20727157 20101231 16328049 18978308 18393292 19418558 16540662 20935162 19208518 19519916 17978847 20512989 18788625 19822196 19171122 18665156 16935385 10737359 19539802 17428255 19052882 18971187 19701751 16779866 19919837 11831363 16288022 21159647 3084413 20524982 18210153 18056438 16569478 16807293 18506893 16681979 16878318 18691550 20214788 19394651 16502159 20432363 17055752 18494052 20084675 19383236 19107877 18785209
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 11.4616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.4616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.461917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3016096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 7.2810977129
MESH:D002386 Cataract Tretinoin 7.2817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.2620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.2612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.2617174075 7505956 21159647 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6416129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4116835633
MESH:D002779 Cholestasis Cyclosporine 7.8419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8417333356 11677210 16919318 16105132 17681005 15861022 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.2216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8012621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.809407595
MESH:D003092 Colitis Tretinoin 3.7517035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.789125849 17551590 8800419 10589399 9211117 16925845 9664655 9142499 9224671 14991402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.788888407 17688650 16575769
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.5916002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0618551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2417107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5019279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.1018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.1014725611 19923254 19416960 16485898 11461765 17562736 18071297 19164858 10915739 12540782 11287661 10774834 14986274 11529661 15968718 14550746 11421492 2444490 19739265 19420014 17522070 10663392 12705907 19370779 16227642 15619225 11834606 17906064 16781746 12153990 16109766 18713872 12392966 11739529 16177239 12594235 16081117 11743745 16393943 19085960 12958197
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.1019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.1020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.101733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.1615322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.1618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.0719031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.7416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.6015700306 16804899
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.6019155303 17893378 16202921 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 12.6016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.193659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9518234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.616254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.113659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0820426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 8.909664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 24.9919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 24.9921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.9915345470
MESH:D005234 Fatty Liver Tamoxifen 24.9914986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 24.9919224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 8.2616002989 16611131 15751030 16513791 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 8.2616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1718558336 8888407
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005355 Fibrosis Cyclosporine 14.9812168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.9820067830
MESH:D005355 Fibrosis Tretinoin 14.9817994277
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Tretinoin 3.0217312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2216084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.589664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9315340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1115340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.7016870215
MESH:D006930 Hyperalgesia Tretinoin 7.7016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6116778211
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4812960047 14722030
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 11.3916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.3916945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.3915036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Diethylnitrosamine 8.3518785209
MESH:D007249 Inflammation Tamoxifen 8.3519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3512200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.8117994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.0316580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.0315992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.8518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.9716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 17.9712371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 17.9715003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Tamoxifen 17.9718625569
MESH:D007859 Learning Disorders Diethylstilbestrol 10.1317184923
MESH:D007859 Learning Disorders sevoflurane 10.1319212262
MESH:D007938 Leukemia Tretinoin 2.7817143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7316482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9017596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9016294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1717301526 9834237 17368321 19035177 16766008 16891316 19029980 16788101 15748426 17361223 16331271 16823087 12679006 17294898 17506722 17107899 16935935 19075265 16140955 17712046 19225113 19642359 17217047 17649720 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.339224671
MESH:D008064 Lipidoses Tamoxifen 3.1717567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8418522880 18407596 19638242 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4618397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.9319014921 11587558 12969438 16611625 19460945 12587719 19784758 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9317034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms Clofibric Acid 14.3717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.3719256749 16942905 19551842 19812893 10737359 19427195 20492335 21047994 20583210 19833225 2862719 18977376 20434301 20137499 20405173 19499222 19850985 18644402 9163691 12771043 21071580 19254457 19090486 18754104 19073162 18648771 15885732 21278145 2422723 19255062 21167192 19294768 18978307 19690152 20118626 20452335 19642983 19996281 20501860 19426721 20101389 12112319 19638242 15175105
MESH:D008113 Liver Neoplasms Diethylstilbestrol 14.3715890375 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 14.3716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.3716984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.8218282651 18079962 2563599 16267830 17854601 19539802 9362446 19009564 18253720 18775883 17942915 19519916 18164116 18544905 16842330 3124819 19004024 18093689 18308698 19126423 21159647 17174075
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8212151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3217228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.3820970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Tamoxifen 3.3818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3819555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5816002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6414580682 16827153 19196722 19196723 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.6119453300
MESH:D008527 Medulloblastoma Tretinoin 2.7917453147
MESH:D008545 Melanoma Tamoxifen 3.3019393235 12393984
MESH:D008545 Melanoma Tretinoin 3.3016752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008569 Memory Disorders sevoflurane 4.7819212262
MESH:D008591 Meningomyelocele Tretinoin 4.4716940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.4517596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.4517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9118551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.769029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Diethylstilbestrol 5.2515313581
MESH:D009369 Neoplasms Tretinoin 5.2516594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 16.6211399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.6214600291
MESH:D009421 Nervous System Malformations Tretinoin 16.629125849
MESH:D009436 Neural Tube Defects Tretinoin 7.369142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.3616359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.2620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4512819281 16049721
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3516936753
MESH:D010146 Pain Acetaminophen 6.6616870215
MESH:D010146 Pain Tretinoin 6.6616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2816540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7115687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.0312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.032563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 16.5817184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.5811896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.5820603192
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.3517136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3515067354
MESH:D011507 Proteinuria Tretinoin 3.6416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.6011422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011625 Pterygium Tretinoin 4.8416723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.9716116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.9719155313
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0018551238
MESH:D012640 Seizures Valproic Acid 6.0011044598 15475178 3137016 11738929 14763951 17978042 1511512 16876388
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6016192470
MESH:D012878 Skin Neoplasms Tretinoin 5.6016467112
MESH:D013088 Spermatocele Diethylstilbestrol 20.5216709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 20.5216709447
MESH:D013088 Spermatocele Tamoxifen 20.5216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0919457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6012833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4218456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4217261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.247505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.2416026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8116051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D014376 Tuberculosis Tretinoin 3.2416040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4216049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.4216712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.4216712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3710091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.6016175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.6016129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.6015809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.6014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.6716752155
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4816513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.0916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D009396 Wilms Tumor Tretinoin 3.9916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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