AutismKB 2.0

Annotation Detail for GCDH


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Basic Information Top
Gene Symbol:GCDH ( ACAD5,GCD )
Gene Full Name: glutaryl-CoA dehydrogenase
Band: 19p13.13
Quick LinksEntrez ID:2639; OMIM: 608801; Uniprot ID:GCDH_HUMAN; ENSEMBL ID: ENSG00000105607; HGNC ID: 4189
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
TRYPTOPHAN-DEGRADATION-1tryptophan degradation III (eukaryotic)
PWY-5177glutaryl-CoA degradation
Pathway IDPathway Name
hsa00310Lysine degradation
hsa00380Tryptophan metabolism
hsa01100Metabolic pathways
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00178Glutaric acidemia
Inherited disorders of amino acid metabolism
Genetic disorders
Desease IDDesease Name
2011Leukoencephalopathy
Desease Name
HEMATOLOGICAL
free glutarate excretion
mean corpuscular hemoglobin
Desease Name
Mean corpuscular hemoglobin
Desease Name
Glutaricaciduria, type I
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GCDH mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GCDH mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of GCDH mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GCDH proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GCDH mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of GCDH mRNAincreases expression 15223131
D002995 Clofibric Acid Clofibric Acid affects the expression of GCDH mRNAaffects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of GCDH mRNAdecreases expression 20106945
C121718 dicyclanil dicyclanil results in increased expression of GCDH mRNAincreases expression 15664270
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GCDH mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GCDH mRNAdecreases expression 18796159
C066340 tolcapone tolcapone binds to GCDH proteinaffects binding 19783845
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0014514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell dicyclanil 18.3817162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.3816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.3816835633
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.4711080934
MESH:D000544 Alzheimer Disease tolcapone 3.3020150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001862 Bone Resorption bisphenol A 3.9711985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8320146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 1.8317123778
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.063084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.0621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 9.0617162532
MESH:D002278 Carcinoma in Situ bisphenol A 5.1417123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.826135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415340226 16354765 8697196 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D003866 Depressive Disorder tolcapone 4.387768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 5.0010440460
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.3518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3519739265 19085960 11461765 15968718 16781746 16177239 14725611 11834606 19416960 12958197 12153990 17906064 19164858 18071297 19420014 10915739 16485898 11421492 17562736 16109766 12594235 12705907 11529661 11287661 14550746 17522070 11739529 16227642 12392966 16081117 16393943 10663392 14986274 12540782 2444490 11743745 18713872 19923254 19370779 10774834 15619225
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3520420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 12.3516604736 19783845
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.5711455177
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 6.1219578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 7.9319224547
MESH:D005234 Fatty Liver pirinixic acid 7.9319236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:C536833 Glutaric aciduria 1 marker/mechanism
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 7.5516393666
MESH:D007333 Insulin Resistance pirinixic acid 7.5516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.9918776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008107 Liver Diseases Acetaminophen 1.6519784758 16611625 19460945 12587719 19014921 16610002 11587558 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 22.537678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 22.532125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 22.5321137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 22.5317602206
MESH:D008113 Liver Neoplasms dicyclanil 22.5320118626
MESH:D008113 Liver Neoplasms pirinixic acid 22.5320007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 22.5316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.192876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.198603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4214755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4218816296 6695378 20464547 17053015 18569708 20869020 20064080 20135361 18520028
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4219555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 10.0111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D010049 Ovarian Diseases bisphenol A 5.1411985600
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010300 Parkinson Disease tolcapone 3.6311432539 8635184 20334432 9708959 7566641 16758261 19578428 9591521 11793426 9305320 10651109 1977408 18328768 20216409 9754991 11586115 8739811 17089403 19783845 11746615 9333106
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.0310548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.0311118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2016740699
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011629 Puberty, Precocious bisphenol A 4.9410548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019966 Substance-Related Disorders bisphenol A 4.1416045194 16684133
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 6.1219578428
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5017053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014591 Uterine Diseases bisphenol A 5.1814652134
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D014820 Vitiligo tolcapone 5.3210573327
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:00071 Fatty acid metabolism
KEGG:00310 Lysine degradation
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00380 Tryptophan metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28604
    • No data
    No data
    Releated drug ID Related drug Name
    PA450280l-lysine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03147 - Flavin-Adenine Dinucleotide
    DB03245 - S-4-Nitrobutyryl-Coa
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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