AutismKB 2.0

Annotation Detail for GCHFR


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Basic Information Top
Gene Symbol:GCHFR ( GFRP,HsT16933,MGC138467,MGC138469,P35 )
Gene Full Name: GTP cyclohydrolase I feedback regulator
Band: 15q15.1
Quick LinksEntrez ID:2644; OMIM: 602437; Uniprot ID:GFRP_HUMAN; ENSEMBL ID: ENSG00000137880; HGNC ID: 4194
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1715Myotonic disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of GCHFR mRNAincreases expression 20713471
D000082 Acetaminophen Acetaminophen affects the expression of GCHFR mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GCHFR proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of GCHFR mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GCHFR mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of GCHFR mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GCHFR mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GCHFR mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of GCHFR mRNAdecreases expression 15336504
D002994 Clofibrate Clofibrate affects the expression of GCHFR mRNAaffects expression 19483382
D002995 Clofibric Acid Clofibric Acid affects the expression of GCHFR mRNAaffects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of GCHFR mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GCHFR mRNAdecreases expression 17108234
D005001 Ethionine Ethionine affects the expression of GCHFR mRNAaffects expression 19483382
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of GCHFR mRNAincreases expression 20713471
D005996 Nitroglycerin Nitroglycerin results in decreased expression of GCHFR mRNAdecreases expression 12102619
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of GCHFR mRNAincreases expression 17616710
D009853 Omeprazole Omeprazole affects the expression of GCHFR mRNAaffects expression 19483382
D017239 Paclitaxel GCHFR protein results in decreased susceptibility to Paclitaxeldecreases response to substance 16734730
C006253 pirinixic acid pirinixic acid affects the expression of GCHFR mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of GCHFR mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GCHFR mRNAincreases expression 16443690
16714409
D013853 Thioacetamide Thioacetamide affects the expression of GCHFR mRNAaffects expression 19483382
D014212 Tretinoin Tretinoin results in increased expression of GCHFR mRNAincreases expression 17045167
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0320127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0314692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.546695378
MESH:D000236 Adenoma Methylcholanthrene 6.546695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3316835633
MESH:D000505 Alopecia Tretinoin 3.4815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9019183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6518057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.8615885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.8616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.2916456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3511922910
MESH:D001281 Atrial Fibrillation Amiodarone 3.7819698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001471 Barrett Esophagus Tretinoin 4.2416935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 63.0019483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 63.0019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 63.0019483382
MESH:D001778 Blood Coagulation Disorders Ethionine 63.0019483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 63.0019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 63.0019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 63.0019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 63.0012125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 63.0019483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 63.0016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.4115867366
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.8811921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.8817474063 20146248
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.8817474063
MESH:D001943 Breast Neoplasms Paclitaxel 2.8811325840 15136595 16115903 18323546 18223236 16273361 18234424 16244791
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8820435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4216813970
MESH:D002277 Carcinoma Methylcholanthrene 7.8810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.033084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.0321507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 11.031701930
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 11.0316313753
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 11.0317997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.031917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4020419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.4016051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2716120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8319225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9118974383
MESH:D002386 Cataract Acetaminophen 6.8910977129
MESH:D002386 Cataract Tretinoin 6.8917460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.1120889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 15.111399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.1112371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 15.1116192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4216129372
MESH:D002637 Chest Pain Omeprazole 4.9315447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0616835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.0618291259
MESH:D002779 Cholestasis Cyclosporine 12.6119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.6117333356 11677210 17681005 16105132 16919318 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 12.6119176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5315668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.539407595
MESH:D003092 Colitis Tretinoin 3.5317035595
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.399125849 17551590 9664655 16925845 14991402 10589399 8800419 9142499 9224671 9211117
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.5611834606 12594235 16227642 17562736 11287661 18713872 19416960 2444490 18071297 17906064 11461765 12540782 14986274 19923254 12705907 11529661 15968718 15619225 10915739 19164858 17522070 16485898 11421492 10663392 14725611 14550746 16781746 11739529 19739265 19420014 12392966 11743745 12958197 10774834 16393943 12153990 16081117 16109766 19370779 16177239 19085960
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.5618218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5620420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.5612963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.1617151854 16613094 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 3.9416707586
MESH:D004487 Edema pirinixic acid 6.0312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3716714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.3718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0212538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.879294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.0720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.0716530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 10.0715623463 15547733 16704527 15264214 16805852 16510608 15547721 15878914 15150132
MESH:D004938 Esophageal Neoplasms Paclitaxel 10.0716481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.4111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.419664655 16938888
MESH:D005218 Fat Necrosis Thioacetamide 5.5516456712
MESH:D005234 Fatty Liver Amiodarone 22.9914986274
MESH:D005234 Fatty Liver Clofibrate 22.9919224547
MESH:D005234 Fatty Liver Cyclosporine 22.9919224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.9915345470
MESH:D005234 Fatty Liver pirinixic acid 22.9920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7710962813 14633661
MESH:D005355 Fibrosis Cyclosporine 13.7312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.7320067830
MESH:D005355 Fibrosis Tretinoin 13.7317994277
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D005909 Glioblastoma Tretinoin 2.9017312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006261 Headache Nitroglycerin 5.0211554966 11284996
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.5720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.579664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4218665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 4.0516456712
MESH:D006529 Hepatomegaly Amiodarone 13.4315265979
MESH:D006529 Hepatomegaly pirinixic acid 13.4318467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.4315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8715340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.1716870215
MESH:D006930 Hyperalgesia Tretinoin 7.1716870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.728137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4016778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D006973 Hypertension Cyclosporine 4.7310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 11.0417991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.048137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3717937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7712878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.5216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.4116580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.4115992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D007674 Kidney Diseases Acetaminophen 5.4712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.478314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.6012371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9619248655
MESH:D007938 Leukemia Tretinoin 2.6917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0519850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0417217047 16788101 16140955 17361223 16331271 17339181 12679006 19075265 16935935 16823087 17506722 19642359 19225113 17294898 16766008 17649720 19029980 17712046 17301526 16891316 15748426 17107899 17368321 9834237 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.199224671
MESH:D008064 Lipidoses Amiodarone 3.3917567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.6617353645
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7812878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.7816098781 17355460 15334695 17629604 14739098 18031379 12891558 18380797 18615449 18458672 12085344 16248980 12557150 18032466 18606216 17292413 16511523 11682029 18263696 18295389 15362042 16343077 17127702 15158331 12175628 15465738 10677585 15288472 15288473 15716488 18395095 15095483 16489207 16126171 12679928 15474484 16097051 15316131 17050028 15075984 18416461 11481614 15078482 12531686 11172339
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.7816248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.9819784758 12969438 16611625 19014921 12587719 19460945 11587558 16610002
MESH:D008107 Liver Diseases Thioacetamide 3.9816337175 15158337 18374380
MESH:D017114 Liver Failure, Acute Acetaminophen 9.1316871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 9.1315313186 15633222 17276928 12479984
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.549163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.5421137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 13.5417602206
MESH:D008113 Liver Neoplasms pirinixic acid 13.5420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.5416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.288603461
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 9.281399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.2812151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4515350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.2612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3118516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.6914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.6918569708 17053015 18816296 18520028 20464547 20135361 20869020 20064080 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 4.6916271038 17909032 16337739 21163286 15390079 11893704 7750092 20512841 20970405 6695378 9230183 10545420 1399818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6911884234 19555203
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.9514749477
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.4711921183
MESH:D008527 Medulloblastoma Tretinoin 2.7217453147
MESH:D008545 Melanoma Paclitaxel 3.4512040289 16342250 12025231
MESH:D008545 Melanoma Tretinoin 3.4516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008591 Meningomyelocele Tretinoin 4.2516940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D008708 Methemoglobinemia Nitroglycerin 4.573537620
MESH:D020326 Migraine without Aura Nitroglycerin 4.9614659530
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0616381670
MESH:D009101 Multiple Myeloma Paclitaxel 3.5714749477
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009181 Mycoses Amiodarone 4.7317974566 12754197
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9817596541
MESH:D009203 Myocardial Infarction Nitroglycerin 5.7814729435
MESH:D009203 Myocardial Infarction pirinixic acid 5.7819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8116411023
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.1915867366
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7011141357
MESH:D009369 Neoplasms pirinixic acid 7.7017405874
MESH:D009369 Neoplasms Tretinoin 7.7016594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9614600291
MESH:D009421 Nervous System Malformations Tretinoin 8.969125849
MESH:D009436 Neural Tube Defects Tretinoin 2.949142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7318514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.779802331
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D010014 Osteolysis Paclitaxel 4.8115867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 4.9111161223
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9116936753
MESH:D010146 Pain Acetaminophen 6.1316870215
MESH:D010146 Pain Tretinoin 6.1316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0211896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4517292933
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.4517136230 17172428 16356831 16729912
MESH:D011507 Proteinuria Tretinoin 3.4416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1416919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1716882103
MESH:D011625 Pterygium Tretinoin 4.6216723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7912490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9416283617 16116481
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9118724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.8910029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.898532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.8916192470
MESH:D012878 Skin Neoplasms Tretinoin 12.8916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7716709447
MESH:D013272 Stomach Diseases Omeprazole 4.4418545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.622093021 20155912
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.6217575124 12958204
MESH:D013274 Stomach Neoplasms Paclitaxel 4.6218506536 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 4.6217261132
MESH:D013276 Stomach Ulcer Amiodarone 7.0618087811
MESH:D013276 Stomach Ulcer Omeprazole 7.0610750652 15991576 16755016 18237397 17977527 11906479
MESH:D013610 Tachycardia Amiodarone 4.1211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0219225199
MESH:D024801 Tauopathies Paclitaxel 4.6416930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Amiodarone 11.4819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.4812697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 6.9915710170
MESH:D013964 Thyroid Neoplasms Tretinoin 6.9916026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.6918020914 19584973
MESH:D014062 Tongue Neoplasms Tretinoin 3.6416051514
MESH:D016171 Torsades de Pointes Amiodarone 4.0211989578 17467628
MESH:D014376 Tuberculosis Tretinoin 3.1216040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1117053015
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4416752155
MESH:D014605 Uveitis Cyclosporine 3.811336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D009396 Wilms Tumor Tretinoin 3.8216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28609
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA447278Depression
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    PA449673fluoxetine
    PA450657nortriptyline
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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