AutismKB 2.0

Annotation Detail for LHX6


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Basic Information Top
Gene Symbol:LHX6 ( LHX6.1,MGC119542,MGC119544,MGC119545 )
Gene Full Name: LIM homeobox 6
Band: 9q33.2
Quick LinksEntrez ID:26468; OMIM: 608215; Uniprot ID:LHX6_HUMAN; ENSEMBL ID: ENSG00000106852; HGNC ID: 21735
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of LHX6 mRNAaffects expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of LHX6 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of LHX6 mRNAdecreases expression 15761015
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LHX6 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of LHX6 mRNAincreases expression 19482888
C105686 SU 5402 SU 5402 results in decreased expression of LHX6 mRNAdecreases expression 15355794
D014212 Tretinoin Tretinoin results in decreased expression of LHX6 mRNAdecreases expression 16000160
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.906195326
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.4317620307
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.2716206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.2716206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2416873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.303581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.303084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 9.3015553829 16217749 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.3017173139 6705139 20007298 20935162 1701930
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.301917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3616096774 16051514
MESH:D002386 Cataract Acetaminophen 7.7810977129
MESH:D002386 Cataract Tretinoin 7.7817460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.389022650 19486331
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7510525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.759664655 16925845 14991402 17551590 9211117 10589399 9142499 9224671 9125849 8800419
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2114531868 11906362 8970840 12868966 2524372 8156756 11298694 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.966482804 9328219 11289319 18289764 1440618 18692083 8291058 7440962 6679447 9653073 18648102 9022650 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9610774834 16109766 16485898 11421492 14550746 17522070 19420014 16781746 11739529 14725611 17906064 12958197 15619225 16177239 19370779 15968718 17562736 12392966 11529661 12705907 10663392 14986274 12153990 11461765 19164858 16393943 2444490 16081117 19923254 19416960 12540782 19085960 12594235 19739265 11743745 16227642 10915739 11834606 18713872 11287661 18071297
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.693581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6912903497
MESH:D005124 Eye Abnormalities Tretinoin 3.8116938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 3.6115073043
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Tretinoin 3.9317994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0414991402 9664655
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly Phenobarbital 3.9016109766
MESH:D006930 Hyperalgesia Acetaminophen 8.4816870215
MESH:D006930 Hyperalgesia Tretinoin 8.4816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 4.2315992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D007938 Leukemia arsenic trioxide 6.8015070760
MESH:D007938 Leukemia Tretinoin 6.8017143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.5819077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.5816932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0316467208 16968895 20471514 17050201 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0319850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.2816330433 16966277 11468182 11161223 19075265 15336539 16112521 19225113 17712046 17217047 9834237 12679006 17107899 16823087 15213294 15622746 12712474 15748426 16891316 16331271 19642359 12018890 19035177 17869043 17649720
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.2819029980 16823087 17217047 17294898 16935935 16788101 17368321 19035177 16766008 17712046 16140955 16891316 12679006 9834237 15748426 17107899 17506722 19642359 16331271 17649720 17301526 19075265 19225113 17361223 17339181
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0521047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 4.1511587558 19014921 16611625 19460945 19784758 12969438 16610002 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.1519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9914682389
MESH:D008113 Liver Neoplasms Phenobarbital 4.9919073162 19812893 21047994 19482888 8742319 15975961
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.961399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.9620377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.9617172636 6150874 1399818 2563599 18308698
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3219417148 14977855 15949261 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.9316882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.9317596541
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms Tretinoin 2.5416594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 13.266679447
MESH:D009436 Neural Tube Defects arsenic trioxide 13.2610525206
MESH:D009436 Neural Tube Defects Tretinoin 13.269142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1412452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1416936753
MESH:D010146 Pain Acetaminophen 7.4916870215
MESH:D010146 Pain Tretinoin 7.4916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 9.1715580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 9.1716965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 9.1715976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011230 Precancerous Conditions Phenobarbital 3.912563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012640 Seizures Phenobarbital 2.894039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D012878 Skin Neoplasms Tretinoin 2.7316467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5217007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.5217261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 19.176587162 6582329 7505956 1399818 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 19.1719014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 19.171399818
MESH:D013964 Thyroid Neoplasms Tretinoin 19.1716026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.428074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.4211780464 20435036 12845720 12973940
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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