AutismKB 2.0

Annotation Detail for NUPR1


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Basic Information Top
Gene Symbol:NUPR1 ( COM1,P8 )
Gene Full Name: nuclear protein, transcriptional regulator, 1
Band: 16p11.2
Quick LinksEntrez ID:26471; OMIM: NA; Uniprot ID:NUPR1_HUMAN; ENSEMBL ID: ENSG00000176046; HGNC ID: 29990
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
2075Heart failure
2128CNS metastases
2129Thyroid cancer
Desease Name
IMMUNE
inflammatory bowel disease (early onset)
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012277 1,2-diamino-4-nitrobenzene 1,2-diamino-4-nitrobenzene results in increased expression of NUPR1 mRNAincreases expression 17070881
C035314 1-nitropropane 1-nitropropane results in increased expression of NUPR1 mRNAincreases expression 17070881
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NUPR1 mRNAdecreases expression 19933214
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of NUPR1 mRNAincreases expression 20713471
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of NUPR1 mRNAdecreases expression 17070881
C025235 2,6-diaminotoluene 2,6-diaminotoluene results in increased expression of NUPR1 mRNAincreases expression 17070881
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NUPR1 mRNAaffects expression 21346803
C014706 2-nitro-4-phenylenediamine 2-nitro-4-phenylenediamine results in increased expression of NUPR1 mRNAincreases expression 17070881
C019499 2-nitrofluorene 2-nitrofluorene results in decreased expression of NUPR1 mRNAdecreases expression 15890375
C016617 2-nitropropane 2-nitropropane results in decreased expression of NUPR1 mRNAdecreases expression 17070881
C028676 4-acetylaminofluorene 4-acetylaminofluorene results in increased expression of NUPR1 mRNAincreases expression 17070881
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of NUPR1 mRNAdecreases expression 15890375
D000082 Acetaminophen Acetaminophen affects the expression of NUPR1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 results in decreased expression of NUPR1 mRNAdecreases expression 15890375
D000638 Amiodarone Amiodarone results in increased expression of NUPR1 mRNAincreases expression 17567588
15342952
D000639 Amitriptyline Amitriptyline results in increased expression of NUPR1 mRNAincreases expression 17567588
15342952
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NUPR1 mRNAaffects expression 16483693
D000968 Antimycin A Antimycin A results in increased expression of NUPR1 mRNAincreases expression 19304788
C006632 arsenic trioxide arsenic trioxide results in increased expression of NUPR1 mRNAincreases expression 19128835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NUPR1 mRNAincreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NUPR1 mRNAincreases expression 20127859
20713471
C032036 bromobenzene bromobenzene results in decreased expression of NUPR1 mRNAdecreases expression 15056800
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NUPR1 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of NUPR1 proteinincreases expression 15962327
D002251 Carbon Tetrachloride NUPR1 gene mutant form results in increased susceptibility to Carbon Tetrachlorideincreases response to substance 15962327
D002251 Carbon Tetrachloride NUPR1 protein affects the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]affects reaction|decreases expression 15962327
D002251 Carbon Tetrachloride NUPR1 protein affects the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]affects reaction|decreases expression 15962327
C084597 chlorcyclizine chlorcyclizine results in increased expression of NUPR1 mRNAincreases expression 15342952
D002746 Chlorpromazine Chlorpromazine results in increased expression of NUPR1 mRNAincreases expression 15342952
D015283 Citalopram Citalopram results in increased expression of NUPR1 mRNAincreases expression 17567588
D002997 Clomipramine Clomipramine results in increased expression of NUPR1 mRNAincreases expression 15342952
D003024 Clozapine Clozapine results in increased expression of NUPR1 mRNAincreases expression 15342952
C030123 coumarin coumarin results in increased expression of NUPR1 mRNAincreases expression 18480146
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of NUPR1 mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine results in increased expression of NUPR1 mRNAincreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of NUPR1 mRNAincreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of NUPR1 mRNAdecreases expression 15890375
D004316 Doxepin Doxepin results in increased expression of NUPR1 mRNAincreases expression 17567588
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NUPR1 mRNAdecreases expression 17108234
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NUPR1 mRNAincreases expression 15576828
D005047 Etoposide NUPR1 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D005419 Flavonoids Flavonoids results in decreased expression of NUPR1 mRNAdecreases expression 18035473
D005424 Flecainide Flecainide results in increased expression of NUPR1 mRNAincreases expression 15342952
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in decreased expression of NUPR1 mRNAdecreases expression 17070881
D005472 Fluorouracil Fluorouracil affects the expression of NUPR1 mRNAaffects expression 16584549
D005473 Fluoxetine Fluoxetine results in increased expression of NUPR1 mRNAincreases expression 15342952
17567588
C010176 halofuginone halofuginone results in decreased expression of NUPR1 mRNAdecreases expression 17180598
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NUPR1 mRNAaffects cotreatment|increases expression 17183730
D007099 Imipramine Imipramine results in increased expression of NUPR1 mRNAincreases expression 15342952
17567588
D007654 Ketoconazole Ketoconazole results in increased expression of NUPR1 mRNAincreases expression 15342952
17567588
D017336 Loratadine Loratadine results in increased expression of NUPR1 mRNAincreases expression 17567588
15342952
D008701 Methapyrilene Methapyrilene results in increased expression of NUPR1 mRNAincreases expression 15890375
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of NUPR1 mRNAdecreases expression 20024957
D010419 Pentamidine Pentamidine results in increased expression of NUPR1 mRNAincreases expression 15342952
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of NUPR1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of NUPR1 mRNAincreases expression 19482888
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of NUPR1 mRNAincreases expression 15890375
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NUPR1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of NUPR1 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of NUPR1 mRNAincreases expression 15890375
C025299 polyphenols polyphenols results in decreased expression of NUPR1 mRNAdecreases expression 16293270
C031280 pyrazole pyrazole results in increased expression of NUPR1 mRNAincreases expression 17945193
D011802 Quinidine Quinidine results in increased expression of NUPR1 mRNAincreases expression 17567588
D012402 Rotenone Rotenone results in increased expression of NUPR1 mRNAincreases expression 19304788
D020280 Sertraline Sertraline results in increased expression of NUPR1 mRNAincreases expression 15342952
17567588
D013629 Tamoxifen Tamoxifen results in increased expression of NUPR1 mRNAincreases expression 17567588
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NUPR1 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NUPR1 mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NUPR1 mRNAdecreases expression 18796159
D013881 Thioridazine Thioridazine results in increased expression of NUPR1 mRNAincreases expression 15342952
D014212 Tretinoin Tretinoin results in increased expression of NUPR1 mRNAincreases expression 16249480
D014241 Trichloroethylene Trichloroethylene results in increased expression of NUPR1 mRNAincreases expression 17905399
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NUPR1 mRNAaffects cotreatment|increases expression 17183730
D015031 Zimeldine Zimeldine results in increased expression of NUPR1 mRNAincreases expression 15342952
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9014745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.576195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.5714514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 10.578875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.3619490988
MESH:D000138 Acidosis Ammonium Chloride 2.9318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3017505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.5418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 11.2819825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.2820127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 11.2816033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 11.2814692618
MESH:D000230 Adenocarcinoma Fluorouracil 11.2817638652
MESH:D000236 Adenoma 2-Acetylaminofluorene 12.7910737359
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 12.7916176798
MESH:D000236 Adenoma Benzo(a)pyrene 12.796695378
MESH:D000236 Adenoma Dimethylnitrosamine 12.7919555203
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.366705139
MESH:D018248 Adenoma, Liver Cell Phenobarbital 13.6417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 13.6416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 13.6416835633
MESH:D000380 Agranulocytosis Clozapine 4.4412649775 16160616 14617031
MESH:D017088 AIDS-Related Opportunistic Infections Pentamidine 5.7211806628
OMIM:607154 ALLERGIC RHINITIS Loratadine 5.1716527031
MESH:D000505 Alopecia Tretinoin 3.1015955085
MESH:D000550 Amblyopia Valproic Acid 4.5917688650
MESH:D000686 Amyloidosis Diethylstilbestrol 3.8815469931
MESH:D000740 Anemia Fluorouracil 6.8417963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.8411748828
MESH:D000799 Angioedema Acetaminophen 3.2010982225
MESH:D001008 Anxiety Disorders Citalopram 17.1218083778
MESH:D001008 Anxiety Disorders Fluoxetine 17.1218083778
MESH:D001008 Anxiety Disorders Sertraline 17.1218822694
MESH:D001008 Anxiety Disorders Valproic Acid 17.1217497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.4519183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 7.6920041841 18057881 18218290
MESH:D001145 Arrhythmias, Cardiac Quinidine 7.6918724381 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.8511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 5.8015885639
MESH:D001169 Arthritis, Experimental Tretinoin 5.8016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.0916292516
MESH:D001249 Asthma Loratadine 4.739196086
MESH:D001249 Asthma Tretinoin 4.7316456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.4118651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 3.1218445737
MESH:D001321 Autistic Disorder Citalopram 3.1218775368 19232924
MESH:D001321 Autistic Disorder Fluoxetine 3.1218775368 19232924
MESH:D001321 Autistic Disorder Sertraline 3.1218775368
MESH:D001321 Autistic Disorder Valproic Acid 3.1216609825 18558336 18177632 19460635 18775368 18940202 17157402 17507914 17688650 20603192 18316065 18985861 15238991 18396377 19232924
MESH:D001471 Barrett Esophagus Tretinoin 3.8016935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.7220046352 17594078
MESH:D001778 Blood Coagulation Disorders Amiodarone 22.7919483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 22.7916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 22.7919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 22.7912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 22.7916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.5815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.588888407
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.5214601052
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 5.9811921183
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 5.9820146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.9817474063 20146248
MESH:D001943 Breast Neoplasms Diethylstilbestrol 5.9815324884 17129689
MESH:D001943 Breast Neoplasms Etoposide 5.9816322251
MESH:D001943 Breast Neoplasms Fluorouracil 5.9819217205 16110121 16557594 18357371 18608205 15136595 16595493
MESH:D001943 Breast Neoplasms Tamoxifen 5.9819115204 18425577 15668708 18984771 19189210 20390343 19142967 19200415 19189212 18997820 19410462 20005174 19084267 20859285 11161223 19487384 20544844 17261762 16202921 17242785 19155303 18855134 21138602 19289846 19011961 17049068 18351453 19103187 15565566 18821012 19221464 19244106 16873071 19066611 18815881 18629630 20135344 19288272 17893378 19059307 16273361 16818667 17440819 21152245 20065188
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.9820435547
MESH:D001943 Breast Neoplasms Tretinoin 5.9816873071 16166294 16443354
MESH:D001943 Breast Neoplasms Trichloroethylene 5.9815986119
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9616813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.7411589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.1618705752 16192424 16124888 15673190 16011737 15700767 16097048 15721981 10355542 16050911 3786805 16227642
MESH:D002276 Carcinoid Tumor Fluorouracil 4.0216051944
MESH:D002277 Carcinoma Dimethylnitrosamine 11.0419555203
MESH:D002277 Carcinoma Fluorouracil 11.0417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.0416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.8919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5116168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 22.5916705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 22.593581430 6705139 17761372 10737359 3084413
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 22.593084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 22.5912907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 22.5914691202 15073043 15553829 11135700 16217749
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 22.5918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 22.5916924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 22.5917045692 17971768 16799960 18930000 16332177 17088986
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 22.5920007298 17173139 1701930 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 22.5916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 22.591917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.2319014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.6818695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.5612490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 8.8620419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 8.8616033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 8.8616757204 16280240 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 8.8616096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.0617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 1.9916120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.6415710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.4518974383
MESH:D002386 Cataract Acetaminophen 5.8710977129
MESH:D002386 Cataract Tretinoin 5.8717460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 8.656135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 8.6512371664
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 8.6519716837
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.634080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9616129372
MESH:D002659 Child Development Disorders, Pervasive Citalopram 5.6715782081
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 5.6720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D002779 Cholestasis Cyclosporine 10.5319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.5316105132 17110522 17681005 11677210 16919318 15861022 17333356
MESH:D002779 Cholestasis pirinixic acid 10.5319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.5116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.7312621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 4.739407595
MESH:D003072 Cognition Disorders Clozapine 4.3517123785
MESH:D003092 Colitis Tretinoin 3.0917035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.4718772588 16510598 17287894 16340194 17172411 17725105 15001691 17169374 17018589 17016597
MESH:D003110 Colonic Neoplasms polyphenols 3.4716293270
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.3520501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.3516391804 20501625 14970324 17016601 18448328 18802399 18288408 17401013 16282729 17594712 18949393 18509181 15289873 17255274 16331619 17695437 16303861 18383874 15148649 16524972 17094418 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5214669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.5812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.5810525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.5810048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.5814991402 9211117 8800419 10589399 9125849 9224671 9142499 16925845 9664655 17551590
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.5816575769 17688650 8888407
MESH:D003456 Cryptorchidism Diethylstilbestrol 3.9512952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.4018551238
MESH:D007644 Darier Disease Fluorouracil 4.1616733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 9.3415213294
MESH:D016757 Death, Sudden, Cardiac Thioridazine 9.3420210726
MESH:D003704 Dementia Thioridazine 5.0111575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7419031437
MESH:D003866 Depressive Disorder Amitriptyline 28.8815014590 18083778
MESH:D003866 Depressive Disorder Citalopram 28.8815014590
MESH:D003866 Depressive Disorder Clomipramine 28.8818083778
MESH:D003866 Depressive Disorder Doxepin 28.8815014590
MESH:D003866 Depressive Disorder Fluoxetine 28.8815014590
MESH:D003866 Depressive Disorder Imipramine 28.8820305041
MESH:D003866 Depressive Disorder Sertraline 28.8815014590 18822694 20305041
MESH:D003865 Depressive Disorder, Major Sertraline 4.8216968574
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.0918249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.1016402076
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 6.1019647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.1017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 2.9419279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.9115331141
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 42.1921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 42.1916445897 20517888 15804453
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 42.1917906064 17522070 19416960 11529661 16781746 16485898 14986274 15968718 11461765 10774834 11834606 11743745 19739265 19420014 14725611 10663392 11287661 2444490 16081117 11421492 18071297 18713872 19085960 15619225 10915739 11739529 16227642 12392966 12958197 14550746 16177239 19164858 16109766 12153990 12705907 19923254 12540782 19370779 16393943 17562736 12594235
MESH:D056486 Drug-Induced Liver Injury Amiodarone 42.1915265979 18218290
MESH:D056486 Drug-Induced Liver Injury bromobenzene 42.1912628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 42.1919085960 19336974 10915739 15027814 16177239 6884620 9327722 7120509 16227642 7179309 15968718 21278145 17522070 3786805 11566570 6623471 7440962 10092053 4309450 15998439 2869522 3732212
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 42.1911461765
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 42.1917654400
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 42.198172417
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 42.1918289764
MESH:D056486 Drug-Induced Liver Injury polyphenols 42.1919370779
MESH:D056486 Drug-Induced Liver Injury pyrazole 42.1912499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 42.1920420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 42.197120509
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 42.191733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.4519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.2811462148
MESH:D050171 Dyslipidemias Clozapine 3.7116402076
MESH:D004421 Dystonia Phenobarbital 8.491851702
MESH:D004421 Dystonia Valproic Acid 8.491851702
MESH:D004487 Edema Amitriptyline 19.8012798668
MESH:D004487 Edema Clomipramine 19.8012798668
MESH:D004487 Edema Fluoxetine 19.8012798668
MESH:D004487 Edema Imipramine 19.8012798668
MESH:D004487 Edema pirinixic acid 19.8012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 19.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.8018230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 9.8018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 6.9612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 6.9619031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.0616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 9.9415700306 16804899
MESH:D016889 Endometrial Neoplasms Tamoxifen 9.9420544844 19155303 16202921 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 9.9416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.479294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 8.743659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 8.7417275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 7.843922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 7.843922381 16628512
MESH:D004827 Epilepsy Phenobarbital 5.4520417680
MESH:D004827 Epilepsy Valproic Acid 5.4518234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 7.076401628
MESH:D004832 Epilepsy, Absence Valproic Acid 7.077562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.257750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.257750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 8.383659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.383659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 8.6512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 8.6516530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 8.6517016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 8.6516337965 16785472 15173087 17638652 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.2111564622
MESH:D005124 Eye Abnormalities Tretinoin 7.219664655 16938888
MESH:D005234 Fatty Liver Amiodarone 33.3914986274
MESH:D005234 Fatty Liver arsenic trioxide 33.3915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.3912795759 15959796 61145 16239168 12631006 19224547 17595544 16045604
MESH:D005234 Fatty Liver Cyclosporine 33.3919224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.3915345470
MESH:D005234 Fatty Liver pirinixic acid 33.3919236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 33.3914986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 33.3914986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.8216002989 16513791 16534752 16611131 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.8216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.2416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.538888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.8914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.5519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 16.0918705752
MESH:D005355 Fibrosis Cyclosporine 16.0912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0920067830
MESH:D005355 Fibrosis Tretinoin 16.0917994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.6616904648
MESH:D005756 Gastritis Acetaminophen 3.0316983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.3116452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.588708960
MESH:D005909 Glioblastoma Tretinoin 2.5817312396
MESH:D005910 Glioma Fluorouracil 2.5816145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9510696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.2918337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5116084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 8.9220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 8.9211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 8.9214991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.1220558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.676705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 3.846705139
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.7915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7711000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.0019900420 19110552
MESH:D006529 Hepatomegaly Amiodarone 15.6415265979
MESH:D006529 Hepatomegaly Phenobarbital 15.6416109766
MESH:D006529 Hepatomegaly pirinixic acid 15.6418467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.6415340226 12621046 16120746
MESH:D006561 Herpes Simplex Chlorpromazine 8.411682908
MESH:D006561 Herpes Simplex Etoposide 8.4110809021
MESH:D006689 Hodgkin Disease Etoposide 3.3515147373 18180244 17606976 16200630 16135485
MESH:D019584 Hot Flashes Fluoxetine 4.6714716179
MESH:D006816 Huntington Disease Sertraline 5.4018403212
MESH:D006849 Hydrocephalus Valproic Acid 4.2317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.408697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 5.9416870215
MESH:D006930 Hyperalgesia Tretinoin 5.9416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9016899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.318137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9516778211
MESH:D006943 Hyperglycemia pirinixic acid 2.6320558911
MESH:D006948 Hyperkinesis Clozapine 4.2816046005
MESH:D006965 Hyperplasia Diethylstilbestrol 9.2612960047 14722030
MESH:D006965 Hyperplasia halofuginone 9.2611874485
MESH:D006973 Hypertension Cyclosporine 3.9910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 3.9918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.4715338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.0116612254
MESH:D007021 Hypospadias Diethylstilbestrol 15.9316002989
MESH:D007021 Hypospadias Ethinyl Estradiol 15.9316569931 16945680
MESH:D007021 Hypospadias Loratadine 15.9316407038
MESH:D007037 Hypothyroidism Amiodarone 3.9017991464 18020914
MESH:D007246 Infertility Diethylstilbestrol 3.7515036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.8812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.0517937319
MESH:D007249 Inflammation Amitriptyline 22.1512798668
MESH:D007249 Inflammation Clomipramine 22.1512798668
MESH:D007249 Inflammation Flavonoids 22.1517296493
MESH:D007249 Inflammation Fluoxetine 22.1512798668
MESH:D007249 Inflammation Imipramine 22.1512798668
MESH:D007249 Inflammation polyphenols 22.1516366677
MESH:D007249 Inflammation Tamoxifen 22.1519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 22.1512878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.2016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.1517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.0416580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.0415992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.7915604871
MESH:D007674 Kidney Diseases Acetaminophen 4.4815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 4.4810903974 8314463 18776723
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.8316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 17.8312371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 17.8314681315 16762066 15003126
MESH:D007680 Kidney Neoplasms Fluorouracil 17.8316985049
MESH:D007680 Kidney Neoplasms Tamoxifen 17.8318625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.4517184923
MESH:D007896 Leishmaniasis Pentamidine 4.8615340016
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 7.7219744259 2166429 8889330 1311351
MESH:D016773 Leishmaniasis, Cutaneous Pentamidine 7.728889330 12453009 11806628 10617787
MESH:D007897 Leishmaniasis, Mucocutaneous Pentamidine 5.4410881086
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 7.3011332679
MESH:D007898 Leishmaniasis, Visceral Pentamidine 7.307715298 10467834 12803856 1659303 7498017 16131481
MESH:D007938 Leukemia arsenic trioxide 5.1615070760
MESH:D007938 Leukemia Tretinoin 5.1617143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.2312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.6716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.9414633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 7.5819077051
MESH:D007951 Leukemia, Myeloid Tretinoin 7.5816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.1719850784 16968895 16467208 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.1717596541 19850784 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.1717596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.1716112521 17217047 11468182 16966277 12712474 17107899 19035177 12018890 17649720 12679006 17712046 16330433 16891316 19225113 15622746 19642359 17869043 15748426 9834237 15336539 19075265 11161223 16823087 16331271 15213294
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.1719642359 16891316 17506722 19035177 16935935 16788101 17301526 17107899 16331271 17361223 17368321 17649720 17712046 19225113 16140955 17339181 19029980 19075265 16766008 16823087 17217047 17294898 15748426 9834237 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.7516882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.849224671
MESH:D008064 Lipidoses Amiodarone 76.5317567588 15342952
MESH:D008064 Lipidoses Amitriptyline 76.5315342952 17567588
MESH:D008064 Lipidoses chlorcyclizine 76.5315342952
MESH:D008064 Lipidoses Chlorpromazine 76.5317567588 15342952
MESH:D008064 Lipidoses Citalopram 76.5317567588
MESH:D008064 Lipidoses Clomipramine 76.5317567588 15342952
MESH:D008064 Lipidoses Clozapine 76.5317567588
MESH:D008064 Lipidoses Fluoxetine 76.5315342952 17567588
MESH:D008064 Lipidoses Imipramine 76.5317567588 15342952
MESH:D008064 Lipidoses Ketoconazole 76.5317567588
MESH:D008064 Lipidoses Loratadine 76.5317567588
MESH:D008064 Lipidoses Sertraline 76.5317567588
MESH:D008064 Lipidoses Tamoxifen 76.5315342952 17567588
MESH:D008064 Lipidoses Thioridazine 76.5315342952 17567588
MESH:D008064 Lipidoses Zimeldine 76.5315342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 8.9416943688 16239168 17334410 16221502 17174718 21278145 11408273 17157831 11903743
MESH:D008103 Liver Cirrhosis halofuginone 8.9417180598
MESH:D008103 Liver Cirrhosis Phenobarbital 8.9421047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.1612741479 15818738 18420326 12649538 17900296 12389079 13678700 17557913 17721639 14748882 12445421 15370692 15123356 18376398 14716833 18263696 17766677 17922224 16116963 15673190 15362042 18472332 18187930 18251166 18339082 15650968 17525996 12632514 17944888 17823541 16033810 17481882 18412020 12445418 18210741 17708605 18705752 17714472 15876570 14716496 16248980 16638106 18395095 17976157 15057751 18472094 17805973 15959796 18156304 15730626 15338365 15893842 10355542 15925388 12609069 15052691 12632512 18054572 14724832 17869086 17565644 12666154 12667390 18277467 12958196 14512876 15996030 14620537 18418968 18006644 17631135 12898905 17640975 16011737 18317297 16136751 18205269 16015684 11481614 12546737 18395914 17698563 18429990 15931870 18279442 17761835 20821823 12586293 16027843 18481824 18166357 16192424 16097048
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 9.1615864749 16169303 18629640 14568256 16544323 17198567 15298665 14726149 15504291 17036385 15138612 15161499 18364076 16603200 17640959 17432682 14709902 14643895 12925901 17201889 18237412 15383259 15086199 18095165 17196135 15591649 17465448 15369754 15793283 15577212 15067225 15723089 15339415 16570917 18672772 17719030 15798949 18239293 15842777 15763062 15733078 17666798 18637143 16627068 17881167 15571005 18210741 17724770 14659978 15099470 18371158 17203207 17534399 16009107 15366600 15492853 17348192 15942678 15081153 15744066 12918455 15479170 18567088 16270385 16042886
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 9.1616489207 14739098 12175628 18458672 11172339
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 9.1618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.1612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 9.1616248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 10.2411587558 16611625 19460945 16610002 19014921 12969438 12587719 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 10.2416964402 16246199 17285989 15720792 15830285
MESH:D008107 Liver Diseases Chlorpromazine 10.2414986274
MESH:D008107 Liver Diseases Phenobarbital 10.2419363144
MESH:D008107 Liver Diseases polyphenols 10.2416698588
MESH:D017093 Liver Failure Carbon Tetrachloride 3.5515123358
MESH:D017114 Liver Failure, Acute Acetaminophen 13.0617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 13.0616899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 13.0617457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 56.437678174
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 56.4318001218 11376686 16273603 10737359 10672840 14678523
MESH:D008113 Liver Neoplasms 2-nitrofluorene 56.4315890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 56.4315890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 56.4318177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms arsenic trioxide 56.4314682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 56.4321137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 56.4319294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 56.4316712894 15890375
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 56.433113478 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 56.4316603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms Methapyrilene 56.4315890375
MESH:D008113 Liver Neoplasms Phenobarbital 56.4319482888 21047994 15975961 19073162 19812893 8742319
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 56.4320101389 19690152 15890375 18648771
MESH:D008113 Liver Neoplasms pirinixic acid 56.4315890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 56.4316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 56.4316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 30.042876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 30.046150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 30.048603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 30.0420377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 30.0412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 30.041848544 6150874 15603536
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 30.041399818 2563599 18308698 6150874 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 30.0412151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 30.047955063
MESH:D008133 Long QT Syndrome Amiodarone 15.4017391786 15350150 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 15.4015213294
MESH:D008133 Long QT Syndrome Quinidine 15.4015350150 11989578
MESH:D008133 Long QT Syndrome Thioridazine 15.4020210726
MESH:D008171 Lung Diseases Amiodarone 2.9312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 9.1218516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 9.1217228818
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 13.1211376686
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 13.1218508827 16061637 17139156 18813816 15893417 12438228 19931552 9255578 16401635 14755239 15172992
MESH:D008175 Lung Neoplasms Aflatoxin B1 13.1214755239
MESH:D008175 Lung Neoplasms arsenic trioxide 13.1211798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 13.1218520028 18816296 20064080 6695378 20135361 18569708 17053015 20464547 20869020
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 13.1216061637 11884234 19555203
MESH:D008175 Lung Neoplasms Fluorouracil 13.1215246190
MESH:D008175 Lung Neoplasms Tamoxifen 13.1218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 13.1219555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.1615086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5215166399
MESH:D008223 Lymphoma Diethylstilbestrol 6.3515700306
MESH:D008223 Lymphoma Etoposide 6.3512854902 12556972
MESH:D016778 Malaria, Falciparum Thioridazine 5.1616882315
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.8716002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.1319428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 4.9311921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 4.9311731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 3.9019453300
MESH:D008527 Medulloblastoma Tretinoin 2.4917453147
MESH:D008545 Melanoma Tamoxifen 2.8219393235 12393984
MESH:D008545 Melanoma Tretinoin 2.8216752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.5515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 2.9519513568
MESH:D008591 Meningomyelocele Tretinoin 3.8116940565
MESH:D001523 Mental Disorders Amitriptyline 42.1516856516
MESH:D001523 Mental Disorders Chlorpromazine 42.1516856516
MESH:D001523 Mental Disorders Citalopram 42.1516856516
MESH:D001523 Mental Disorders Clomipramine 42.1516856516
MESH:D001523 Mental Disorders Clozapine 42.1516856516
MESH:D001523 Mental Disorders Doxepin 42.1516856516
MESH:D001523 Mental Disorders Fluoxetine 42.1516856516
MESH:D001523 Mental Disorders Imipramine 42.1516856516
MESH:D001523 Mental Disorders Sertraline 42.1516856516
MESH:D001523 Mental Disorders Thioridazine 42.1516856516
MESH:D024821 Metabolic Syndrome X Clozapine 3.8819142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.1416801185
MESH:D008881 Migraine Disorders Amitriptyline 6.5718803445
MESH:D008881 Migraine Disorders Valproic Acid 6.5718803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 6.8716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 6.8716757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 2.6419417148 14977855 19549372 15949261 11468182
MESH:D009135 Muscular Diseases pirinixic acid 2.8916239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.468888407
MESH:D009175 Mycoplasma Infections Chlorpromazine 5.3510773494
MESH:D009181 Mycoses Amiodarone 4.2612754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.0318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 10.0016105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 10.0017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 10.0017596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.8519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.4516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.8417484760
MESH:D009207 Myoclonus Fluoxetine 5.248041377
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.877678174 18551238
MESH:D009336 Necrosis 2-nitropropane 8.8712195237
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.3616624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.2619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 15.1911141357
MESH:D009369 Neoplasms Diethylstilbestrol 15.1915313581
MESH:D009369 Neoplasms Fluorouracil 15.1916928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 15.1917405874
MESH:D009369 Neoplasms Tretinoin 15.1916946489 16594593
MESH:D009369 Neoplasms Trichloroethylene 15.1911911487
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.3619189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.7917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.7519348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.3815790535 17356569 18619942
MESH:D009421 Nervous System Malformations Diethylstilbestrol 12.9211399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 12.9214600291
MESH:D009421 Nervous System Malformations Tretinoin 12.929125849
MESH:D009436 Neural Tube Defects arsenic trioxide 9.6010525206
MESH:D009436 Neural Tube Defects Tretinoin 9.609142499
MESH:D009436 Neural Tube Defects Valproic Acid 9.608888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.3518514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 2.9916436463
MESH:D009765 Obesity Clozapine 4.0218515891 19142110
MESH:D009765 Obesity pirinixic acid 4.0220558911
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 4.8720418887
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 2.8816049721
MESH:D010018 Osteomalacia Phenobarbital 3.7317016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.0616624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 4.0616936753
MESH:D010146 Pain Acetaminophen 19.8016870215
MESH:D010146 Pain Amitriptyline 19.8012798668
MESH:D010146 Pain Clomipramine 19.8012798668
MESH:D010146 Pain Fluoxetine 19.8012798668
MESH:D010146 Pain Imipramine 19.8012798668
MESH:D010146 Pain Tretinoin 19.8016870215
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 16.9012384795
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 16.9015580305
MESH:D010190 Pancreatic Neoplasms Etoposide 16.9019003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 16.9019003803 15113037 16500647 16929163
MESH:D010190 Pancreatic Neoplasms Phenobarbital 16.9016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 16.9015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1011578682
MESH:D010235 Paraganglioma arsenic trioxide 3.5719927285
MESH:D010300 Parkinson Disease Rotenone 2.7116140633 11535288 16412576 19232380 18191903 18619942 11445065 19114014 15451049
MESH:D020734 Parkinsonian Disorders Rotenone 3.5215795934 15927086 15574749 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6012520081
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.388041377
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.5214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.0515687265 16977796
MESH:D011020 Pneumonia, Pneumocystis Pentamidine 6.0715340016
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9618163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.1812371664
MESH:D011230 Precancerous Conditions Phenobarbital 7.182563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 12.6217184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 12.6211118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 12.6220603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9817292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9815046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Etoposide 1.9817172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9818626508 19082440
MESH:D011471 Prostatic Neoplasms Ketoconazole 1.9817404083
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9815067354
MESH:D011507 Proteinuria Tretinoin 3.0216636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.6915861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 10.0412752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.0411422049 12752131
MESH:D011565 Psoriasis Cyclosporine 1.9716882103
MESH:D011618 Psychotic Disorders Clozapine 7.9415331141
MESH:D011618 Psychotic Disorders Thioridazine 7.9416882315
MESH:D011625 Pterygium Tretinoin 4.1616723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.5812490602 11597910 12832656
MESH:D012004 Rectal Neoplasms Fluorouracil 3.4718286688 16160472 18722050 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.0419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 8.9116116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 8.9119155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.4516646077
MESH:D012512 Sarcoma, Ewing's Etoposide 8.4514601052
MESH:D012559 Schizophrenia Clozapine 3.4019369910 17726453 20521326 20168265 17123785 11763009 11151749 17667964 16141801 20107430 20452607 18855531 20521320 20580759 18806925
MESH:D012559 Schizophrenia Valproic Acid 3.4019110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 7.2318551238
MESH:D012640 Seizures Phenobarbital 7.2311442880 16876388 4039156 3137016
MESH:D012640 Seizures Valproic Acid 7.2317978042 1511512 16876388 14763951 11738929 3137016 15475178 11044598
MESH:D003294 Seizures, Febrile Phenobarbital 4.196407741
MESH:D020230 Serotonin Syndrome Fluoxetine 5.258704074
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.4518724381
MESH:D012871 Skin Diseases halofuginone 4.9611874485
MESH:D012871 Skin Diseases monomethylarsonous acid 4.9617431481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 7.4010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.4016192470
MESH:D012878 Skin Neoplasms Tretinoin 7.4016467112
MESH:D012892 Sleep Deprivation Imipramine 5.5619798453
MESH:D007319 Sleep Initiation and Maintenance Disorders Amitriptyline 8.9615341891
MESH:D007319 Sleep Initiation and Maintenance Disorders Doxepin 8.9615341891
MESH:D013088 Spermatocele Diethylstilbestrol 16.4116002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 16.4116709447
MESH:D013088 Spermatocele Tamoxifen 16.4116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.4119457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.2819490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.6212587719
MESH:D013226 Status Epilepticus Valproic Acid 3.9012833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.4117007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.4120155912 2093021
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 5.4116033868
MESH:D013274 Stomach Neoplasms Fluorouracil 5.4115786421 17172411 19084572 19015929 17522103 18567086 16424979 18396642 17498489 16951190
MESH:D013274 Stomach Neoplasms Tretinoin 5.4117261132
MESH:D013276 Stomach Ulcer Amiodarone 2.7818087811
MESH:D013610 Tachycardia Amiodarone 3.6911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 8.9019225199
MESH:D017180 Tachycardia, Ventricular Thioridazine 8.9020210726
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.6117997062
MESH:D013733 Testicular Diseases pyrazole 4.196499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6215669648
MESH:D013959 Thyroid Diseases Amiodarone 9.9119731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 9.9112697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 9.1319014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 9.131399818
MESH:D013964 Thyroid Neoplasms Tretinoin 9.1317045167 16026305
MESH:D013971 Thyrotoxicosis Amiodarone 4.2419584973 18020914
MESH:D014062 Tongue Neoplasms Fluorouracil 7.9816280240
MESH:D014062 Tongue Neoplasms Tretinoin 7.9816051514
MESH:D016171 Torsades de Pointes Amiodarone 13.8511989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 13.8515213294
MESH:D016171 Torsades de Pointes Flecainide 13.8517467628
MESH:D014178 Translocation, Genetic Valproic Acid 4.5917262798
MESH:D014352 Trypanosomiasis Pentamidine 5.8715340016
MESH:D014376 Tuberculosis Tretinoin 2.8116040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.893119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 19.5816049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 19.581399818 15289314 15867355
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 19.5812973940 11780464 20435036 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 19.5817053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 19.5816712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 19.5820375083
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 19.5816712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.028888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.6810091137
MESH:D014581 Urticaria Acetaminophen 7.3110982225
MESH:D014581 Urticaria Loratadine 7.312568013
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 12.6916175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 12.6916803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 12.6916129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.5214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.4816690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.4814692618
MESH:D014604 Uveal Neoplasms Tretinoin 3.9616752155
MESH:D014605 Uveitis Cyclosporine 3.341336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.8216513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9512125929
MESH:D014689 Venous Insufficiency coumarin 5.1312708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.9714671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.4516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6015886252
MESH:D015430 Weight Gain Clozapine 3.9320564506 17502770 20521320 20107430 16402076 16141801
MESH:D015431 Weight Loss Clozapine 4.4417933447
MESH:D009396 Wilms Tumor Tretinoin 3.4216287080
MESH:D014985 Xerophthalmia Cyclosporine 3.7917120751
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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