AutismKB 2.0

Annotation Detail for KAT2A


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Basic Information Top
Gene Symbol:KAT2A ( GCN5,GCN5L2,MGC102791,PCAF-b,hGCN5 )
Gene Full Name: K(lysine) acetyltransferase 2A
Band: 17q21.2
Quick LinksEntrez ID:2648; OMIM: 602301; Uniprot ID:KAT2A_HUMAN; ENSEMBL ID: ENSG00000108773; HGNC ID: 4201
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04330Notch signaling pathway
Pathway IDPathway Name
Gene Expression
Pathway IDPathway Name
200002Regulation of nuclear SMAD2/3 signaling
200093C-MYC pathway
200045Validated targets of C-MYC transcriptional activation
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003994 Bucladesine Bucladesine inhibits the reaction [CTBP1 protein binds to KAT2A protein]affects binding|decreases reaction 18184656
C017947 sodium arsenite sodium arsenite results in decreased expression of KAT2A mRNAdecreases expression 19822182
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.7715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.9716712894 17306315
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0115276417 17306315 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4818572023
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.3119524636 20056578
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.5716452187
MESH:D006689 Hodgkin Disease sodium arsenite 3.6212676792
MESH:D007248 Infertility, Male sodium arsenite 3.2912646999 15346721
MESH:D007674 Kidney Diseases sodium arsenite 3.0420008137
MESH:D008113 Liver Neoplasms sodium arsenite 2.5116712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.4819095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.9017306315 19931552 16712894 15276417 17077188
MESH:D008545 Melanoma sodium arsenite 2.0819082730 16487513
MESH:D009369 Neoplasms sodium arsenite 2.6911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.4320056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.4412854658
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5417306315 15276417
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2316039940
MESH:D012878 Skin Neoplasms sodium arsenite 2.8819524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1812854658
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6511723127 17306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.2711813266
MESH:D014652 Vascular Diseases sodium arsenite 5.3117056641
Pathway ID Pathway Name
REACT:71 Gene Expression
KEGG:04330 Notch signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162392664
    • No data
    No data
    Releated drug ID Related drug Name
    PA152241907lapatinib
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01992 - Coenzyme A
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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