AutismKB 2.0

Annotation Detail for NR6A1


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Basic Information Top
Gene Symbol:NR6A1 ( GCNF,GCNF1,NR61,RTR )
Gene Full Name: nuclear receptor subfamily 6, group A, member 1
Band: 9q33.3
Quick LinksEntrez ID:2649; OMIM: 602778; Uniprot ID:NR6A1_HUMAN; ENSEMBL ID: ENSG00000148200; HGNC ID: 7985
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Gene Expression
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NR6A1 mRNAdecreases expression 19933214
C006780 bisphenol A bisphenol A affects the expression of NR6A1 mRNAaffects expression 14967926
D003907 Dexamethasone Dexamethasone results in increased expression of NR6A1 mRNAincreases expression 19022236
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NR6A1 mRNAincreases expression 17108234
D018038 Sodium Selenite Sodium Selenite results in decreased expression of NR6A1 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NR6A1 mRNAdecreases expression 19933214
D014212 Tretinoin Tretinoin promotes the reaction [NR6A1 protein binds to TDGF1 promoter]affects binding|increases reaction 16954206
D014212 Tretinoin Tretinoin promotes the reaction [NR6A1 protein binds to TDGF3 promoter]affects binding|increases reaction 16954206
D014212 Tretinoin Tretinoin results in increased activity of NR6A1 proteinincreases activity 16954206
D014212 Tretinoin NR6A1 protein affects the reaction [Tretinoin results in decreased expression of DPPA3 mRNA]affects reaction|decreases expression 16166633
D014212 Tretinoin NR6A1 protein affects the reaction [Tretinoin results in decreased expression of FGF4 mRNA]affects reaction|decreases expression 16166633
D014212 Tretinoin NR6A1 protein affects the reaction [Tretinoin results in decreased expression of NANOG mRNA]affects reaction|decreases expression 16166633
D014212 Tretinoin NR6A1 protein affects the reaction [Tretinoin results in decreased expression of POU5F1 mRNA]affects reaction|decreases expression 16166633
D014212 Tretinoin NR6A1 protein affects the reaction [Tretinoin results in decreased expression of SOX2 mRNA]affects reaction|decreases expression 16166633
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Dexamethasone 13.2117659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 13.2115885639
MESH:D001169 Arthritis, Experimental Tretinoin 13.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.8912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.8916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 1.8617123778
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.911917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717333356 16919318 17110522 16105132 11677210 17681005 15861022
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0912621046 16354765 15668235 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 6.099407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5315824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.9517728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9510048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.9514991402 16925845 8800419 9211117 9125849 9664655 17551590 9142499 10589399 9224671
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.7612438553
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003967 Diarrhea Dexamethasone 4.027237001
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004485 Eczema Dexamethasone 4.7912438553
MESH:D004487 Edema Dexamethasone 7.8219703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.8211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.4718230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 13.4718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.5211564622
MESH:D005124 Eye Abnormalities Tretinoin 9.529664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8420067830
MESH:D005355 Fibrosis Tretinoin 9.8417994277
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.9714991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.157520565
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006973 Hypertension Dexamethasone 5.5517042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Dexamethasone 5.5111099482 8960868
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5112200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 8.1216393666
MESH:D007333 Insulin Resistance Sodium Selenite 8.1214714311
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.8916580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.8915992940 17551590
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1119850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3217361223 16766008 17294898 12679006 16788101 19029980 19642359 17368321 17649720 16140955 16935935 17506722 19035177 16331271 19075265 17217047 17301526 15748426 9834237 19225113 17712046 16891316 16823087 17339181 17107899
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.6616718785
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6616248980 18397230
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Dexamethasone 2.5115824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5119555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3614737004
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D009101 Multiple Myeloma Dexamethasone 3.6915867202 16118317 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 8.019809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.0117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009369 Neoplasms Tretinoin 2.5216594593 16946489
MESH:D009421 Nervous System Malformations bisphenol A 18.3811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 18.3814600291
MESH:D009421 Nervous System Malformations Tretinoin 18.389125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4116936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6821297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.8610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.8611896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3216740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3218760546
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.3218379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016283617 16116481
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9416192470
MESH:D012878 Skin Neoplasms Tretinoin 5.9416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013272 Stomach Diseases Dexamethasone 4.7215472012
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.7615138204
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014605 Uveitis Dexamethasone 5.261336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
Pathway ID Pathway Name
REACT:71 Gene Expression
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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