AutismKB 2.0

Annotation Detail for GCNT1


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Basic Information Top
Gene Symbol:GCNT1 ( C2GNT,C2GNT-L,C2GNT1,G6NT,MGC126335,MGC126336,NACGT2,NAGCT2 )
Gene Full Name: glucosaminyl (N-acetyl) transferase 1, core 2
Band: 9q21.13
Quick LinksEntrez ID:2650; OMIM: 600391; Uniprot ID:GCNT1_HUMAN; ENSEMBL ID: ENSG00000187210; HGNC ID: 4203
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00512O-Glycan biosynthesis
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1831Prostate cancer
1904Diabetes mellitus
2040Hyperglycemia
2051Leukemia
2239Lymphoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GCNT1 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GCNT1 mRNAincreases expression 15336504
D003345 Corticosterone Corticosterone results in increased expression of GCNT1 mRNAincreases expression 15755911
D002945 Cisplatin Cisplatin results in decreased expression of GCNT1 proteindecreases expression 16803524
D002117 Calcitriol Calcitriol results in decreased expression of GCNT1 mRNAdecreases expression 16002434
D009151 Mustard Gas Mustard Gas results in increased expression of GCNT1 mRNAincreases expression 15674844
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GCNT1 mRNAaffects binding|decreases expression|increases activity 19710929
D020849 Raloxifene Raloxifene affects the expression of GCNT1 mRNAaffects expression 14699072
D013467 Sulindac Sulindac results in increased expression of GCNT1 mRNAincreases expression 11093808
D014284 Triiodothyronine Triiodothyronine results in decreased expression of GCNT1 mRNAdecreases expression 19228888
D015032 Zinc Zinc results in increased expression of GCNT1 mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of GCNT1 mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.6714745880
MESH:D000138 Acidosis Ammonium Chloride 11.1418287403
MESH:D000138 Acidosis Zinc Sulfate 11.147265320
MESH:D000169 Acrodermatitis Zinc 5.5617190629 16889938 17202136
MESH:D058186 Acute Kidney Injury Cisplatin 9.4217670903 15814532 12690470
MESH:D058186 Acute Kidney Injury Sulindac 9.427897758
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Cisplatin 5.0217638652 11798837
MESH:D000230 Adenocarcinoma Sulindac 5.0211910360
MESH:D000236 Adenoma Sulindac 3.8410223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.7011535846 15623613 19003578 11874996 16460482 12394442 17611924
MESH:D000419 Albuminuria Raloxifene 4.7217451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 4.5715800139
MESH:D000544 Alzheimer Disease Zinc 4.5716580781 16325427 16410023 17119284
MESH:D000755 Anemia, Sickle Cell Zinc 5.0316916123
MESH:D000860 Anoxia Zinc Sulfate 5.177265320
MESH:D001249 Asthma Mustard Gas 5.3110378619
MESH:D001249 Asthma Zinc 5.3117085522
MESH:D001768 Blister Mustard Gas 5.3119167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.0614601052
MESH:D001913 Bowen's Disease Sulindac 5.5311207687
MESH:D001930 Brain Injuries Raloxifene 11.5916580743
MESH:D001930 Brain Injuries Zinc 11.5917109824
MESH:D001943 Breast Neoplasms Calcitriol 2.0811237771
MESH:D001943 Breast Neoplasms Cisplatin 2.0819526202 18382427
MESH:D001943 Breast Neoplasms Raloxifene 2.0815572757 17242785 16912660 17595753 17440819 17952589 15758505 17049068 17893378 17261762 15775269 16837676
MESH:D001943 Breast Neoplasms Sulindac 2.0816642371
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1517687719 10378619
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 2.4317982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0716685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.9011237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.9017066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Zinc 7.9016543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1717572228
MESH:D002318 Cardiovascular Diseases Raloxifene 7.8815775269
MESH:D002318 Cardiovascular Diseases Zinc 7.8816936243
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D003110 Colonic Neoplasms Sulindac 2.9312902858 12458338
MESH:D015179 Colorectal Neoplasms Cisplatin 2.9915273666
MESH:D015179 Colorectal Neoplasms Sulindac 2.9911197048 10666051 11076880 18059344
MESH:D019465 Craniofacial Abnormalities Zinc 2.4319302082
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003920 Diabetes Mellitus Zinc 4.3016479319
MESH:D003928 Diabetic Nephropathies Raloxifene 4.0315920148 17451421 17308373
MESH:D003930 Diabetic Retinopathy Sulindac 5.3012861449 17621415
MESH:D004362 Drug Toxicity Cisplatin 3.9412649298 15033597 12231392 19839026
MESH:D004487 Edema Mustard Gas 12.209260866 11402378 11428631 11428647
MESH:D004487 Edema pirinixic acid 12.2012083418
MESH:D004487 Edema Raloxifene 12.2015860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.8215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.8215845917
MESH:D004715 Endometriosis Sulindac 4.5815652904
MESH:D004890 Erythema Mustard Gas 5.319357497
MESH:D004938 Esophageal Neoplasms Cisplatin 7.6815173087 17638652 15464296 16785472 16481741
MESH:D004938 Esophageal Neoplasms Sulindac 7.6812235107
MESH:D004938 Esophageal Neoplasms Zinc 7.6816543248
MESH:D005234 Fatty Liver pirinixic acid 8.2120131406 19236843
MESH:D005234 Fatty Liver Raloxifene 8.2117473493
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.6314745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.2919069698
MESH:D005756 Gastritis Zinc 4.9717241300
MESH:D005764 Gastroesophageal Reflux Sulindac 5.1411910360
MESH:D006130 Growth Disorders Zinc 4.0317217573
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.7915464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.3919898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5115464296
MESH:D006331 Heart Diseases Raloxifene 3.6111110106
MESH:D006333 Heart Failure pirinixic acid 7.3620558911
MESH:D006333 Heart Failure Zinc 7.3617162251
MESH:D006335 Heart Injuries Zinc 5.9417074742
MESH:D016481 Helicobacter Infections Zinc 4.6517241300
MESH:D006527 Hepatolenticular Degeneration Zinc 11.7917276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 11.7917063115
MESH:D006529 Hepatomegaly pirinixic acid 3.1319176532 16221962 18467677 19772884
MESH:D006689 Hodgkin Disease Cisplatin 3.6916200630 16170182
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Raloxifene 2.9017577099 15787275
MESH:D007022 Hypotension Zinc Sulfate 4.597265320
MESH:D007249 Inflammation Mustard Gas 5.7611402378 11428620 11428631 8975870 9357497 17524151 11428647 9260866 16001271
MESH:D007249 Inflammation Sulindac 5.763291741
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.7410213222 12663524 12584176 10223192 12351151 12628509
MESH:D007417 Intestinal Polyps Sulindac 5.1011245490 12394442
MESH:D007511 Ischemia Zinc 4.7716584753
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.3115464296
MESH:D007674 Kidney Diseases Cisplatin 6.7418289764 12649298 12231392 15190930 19839026
MESH:D007674 Kidney Diseases Zinc 6.7416960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5316518626
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.9711231351
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.3515237267
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.2912468960
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Sulindac 3.0514986274 16867024
MESH:D008113 Liver Neoplasms pirinixic acid 1.8520007298 16377806 15890375
MESH:D008171 Lung Diseases Mustard Gas 3.5218702808 18161513
MESH:D008175 Lung Neoplasms Cisplatin 3.7611798837 6189445 17225452
MESH:D008175 Lung Neoplasms Mustard Gas 3.768781369 3148597
MESH:D008175 Lung Neoplasms Sulindac 3.7619359593 15713900
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 6.8412807724
MESH:D008325 Mammary Neoplasms, Experimental Zinc 6.8412773700
MESH:D008545 Melanoma Cisplatin 3.8816432458 12883367 18505091 12374674 15577323 18332650 17023156 11135225 16248763 17761969 16809738 18176117 12393984
MESH:D008545 Melanoma Sulindac 3.8816642371
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.9315990972
MESH:D008654 Mesothelioma Cisplatin 3.2817638057
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5116497877
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009369 Neoplasms Cisplatin 5.2716773208
MESH:D009369 Neoplasms pirinixic acid 5.2717405874
MESH:D009395 Nephritis, Interstitial Cisplatin 4.6715464296
MESH:D009447 Neuroblastoma Cisplatin 3.508761367
MESH:D019636 Neurodegenerative Diseases Sulindac 4.3617266991 16850258
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.858761367
MESH:D009503 Neutropenia Mustard Gas 4.097688884 16761898
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010024 Osteoporosis Raloxifene 3.4619059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3417893378 17823083 15758505 15579764
MESH:D010051 Ovarian Neoplasms Cisplatin 2.906897625 15464296 19769630 17225452
MESH:D010146 Pain Sulindac 3.883291741
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.9119003803
MESH:D010190 Pancreatic Neoplasms Sulindac 5.9116820089 11504793
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4315464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.5217638057
MESH:D011041 Poisoning Mustard Gas 3.9115727166
MESH:D011225 Pre-Eclampsia Zinc 4.2617114810
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9315572423
MESH:D011471 Prostatic Neoplasms marker/mechanism 15882971
MESH:D011471 Prostatic Neoplasms Calcitriol 2.7216289102 18247401 12479363 15754350 16644109
MESH:D011471 Prostatic Neoplasms Raloxifene 2.7216220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Zinc 2.7212429649 16606632 16517595 16700911
MESH:D011537 Pruritus Mustard Gas 4.2518058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9610334151 17266442 17720292 17894541 17620002
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D051437 Renal Insufficiency Cisplatin 4.5515464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012162 Retinal Degeneration Zinc 4.2116584753
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.5514601052
MESH:D012871 Skin Diseases Mustard Gas 2.7416961503 12880345 15451306
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.748532709
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.5215464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.3317522103 18396642 15958060
MESH:D020521 Stroke Raloxifene 3.9116837676
MESH:D013736 Testicular Neoplasms Cisplatin 4.7515464296 17225452
MESH:D013978 Tibial Fractures Raloxifene 5.3819048282
MESH:D014062 Tongue Neoplasms Zinc 4.5016543248
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.5817225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5817572228
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.3116803524
MESH:D014594 Uterine Neoplasms Sulindac 4.7318645019
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7515577323
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D014839 Vomiting Cisplatin 4.8911897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00512 Mucin type O-Glycan biosynthesis
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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