AutismKB 2.0

Annotation Detail for CNNM4


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Basic Information Top
Gene Symbol:CNNM4 ( ACDP4,FLJ37746,FLJ42791,KIAA1592 )
Gene Full Name: cyclin M4
Band: 2q11.2
Quick LinksEntrez ID:26504; OMIM: 607805; Uniprot ID:CNNM4_HUMAN; ENSEMBL ID: ENSG00000158158; HGNC ID: 105
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CNNM4 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of CNNM4 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CNNM4 mRNAincreases expression 20106945
D002118 Calcium Calcium affects the expression of CNNM4 mRNAaffects expression 15913539
C006253 pirinixic acid pirinixic acid results in increased expression of CNNM4 mRNAincreases expression 18301758
D013467 Sulindac Sulindac results in increased expression of CNNM4 mRNAincreases expression 11906190
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 6.0214745880
MESH:D058186 Acute Kidney Injury Sulindac 4.647897758
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.8720127859 20464547
MESH:D000230 Adenocarcinoma Sulindac 4.8711910360
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 12.233712494
MESH:D000236 Adenoma Benzo(a)pyrene 12.236695378
MESH:D000236 Adenoma Sulindac 12.2310223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.9011874996 15623613 11535846 12394442 17611924 16460482 19003578
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001913 Bowen's Disease Sulindac 5.8711207687
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4017474063 20146248
MESH:D001943 Breast Neoplasms Sulindac 2.4016642371
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.933581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.629022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.6219176532
MESH:D003110 Colonic Neoplasms Sulindac 2.9612902858 12458338
MESH:D015179 Colorectal Neoplasms Sulindac 2.6918059344 10666051 11076880 11197048
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2111298694 14531868 8156756 11906362 8970840 2524372 12868966 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D003930 Diabetic Retinopathy Sulindac 5.5612861449 17621415
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9618289764 18648102 8291058 1440618 9022650 9328219 18692083 6482804 16192314 11289319 6679447 7440962 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9616485898 18071297 19370779 17906064 15619225 18713872 17562736 16781746 10663392 11287661 16393943 10915739 11529661 19739265 19420014 16177239 12392966 19085960 12540782 16109766 10774834 11743745 12153990 12705907 14550746 11461765 19923254 16081117 19164858 14725611 16227642 15968718 12594235 11739529 12958197 19416960 14986274 17522070 2444490 11421492 11834606
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004715 Endometriosis Sulindac 4.7815652904
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.723581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.7216530937
MESH:D004938 Esophageal Neoplasms Sulindac 7.7212235107
MESH:D005234 Fatty Liver pirinixic acid 3.0919236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.9414745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.5919069698
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005764 Gastroesophageal Reflux Sulindac 5.3911910360
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly pirinixic acid 3.4116221962 18467677 19772884 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007249 Inflammation Sulindac 3.443291741
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.9412351151 10223192 12628509 12584176 10213222 12663524
MESH:D007417 Intestinal Polyps Sulindac 5.3411245490 12394442
OMIM:217080 JALILI SYNDROME marker/mechanism
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.5716316344
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 9.119327722 15034207
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 9.1112468960
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.4612969438 11587558 16611625 12587719 16610002 19460945 19784758 19014921
MESH:D008107 Liver Diseases Sulindac 4.4614986274 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7020195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 4.7020007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.71598648 3712494 6587162 1399818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.7918520028 20135361 17053015 6695378 18569708 20869020 20464547 20064080 18816296
MESH:D008175 Lung Neoplasms Sulindac 2.7919359593 15713900
MESH:D008545 Melanoma Sulindac 2.8616642371
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2811141357
MESH:D009369 Neoplasms pirinixic acid 5.2817405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.4318514411
MESH:D019636 Neurodegenerative Diseases Sulindac 9.4317266991 16850258
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010024 Osteoporosis Calcium 3.9617882678
MESH:D010146 Pain Acetaminophen 7.8116870215
MESH:D010146 Pain Sulindac 7.813291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4411504793 16820089
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9217292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4919755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.127505956 6582329 6587162 1399818 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.318074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3117053015
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014594 Uterine Neoplasms Sulindac 4.9818645019
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26671
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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