AutismKB 2.0

Annotation Detail for INTS6


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Basic Information Top
Gene Symbol:INTS6 ( DBI-1,DDX26,DDX26A,DICE1,DKFZp434B105,HDB,INT6,Notchl2 )
Gene Full Name: integrator complex subunit 6
Band: 13q14.3
Quick LinksEntrez ID:26512; OMIM: 604331; Uniprot ID:INT6_HUMAN; ENSEMBL ID: ENSG00000102786; HGNC ID: 14879
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of INTS6 mRNAdecreases expression 19933214
C006632 arsenic trioxide arsenic trioxide results in increased expression of INTS6 mRNAincreases expression 20458559
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of INTS6 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of INTS6 mRNAdecreases expression 20018196
19150397
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of INTS6 mRNAaffects expression 17555576
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of INTS6 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of INTS6 mRNAdecreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of INTS6 mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate affects the expression of INTS6 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of INTS6 mRNAdecreases expression 19933214
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of INTS6 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of INTS6 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4111798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4114692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.5416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9416873071 15668708 19200415 20544844 17049068 18815881 16273361 19155303 21152245 19221464 17261762 15565566 19103187 19084267 20390343 19142967 18984771 11161223 20005174 19189212 19487384 17893378 17440819 18821012 19410462 20135344 20859285 18855134 21138602 18629630 19059307 20065188 19244106 18351453 19288272 16202921 19066611 19011961 19289846 19115204 17242785 18997820 18425577 19189210 16818667
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1215553829 14691202 11135700 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1216924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8420889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0011677210 16105132 17333356 16919318 17110522 17681005 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.168697196 12621046 15340226 15668235 16354765
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8619769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Selenium 3.9215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1516202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5912903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver arsenic trioxide 14.1415073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.1415345470
MESH:D005234 Fatty Liver Tamoxifen 14.1419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8516080930
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0117440010
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116354765 8697196 18606429 15340226 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Tamoxifen 5.1619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1612200463 12878042
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Vitamin E 2.8912488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1918625569
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 19850784 16968895 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3216823087 12679006 12712474 11161223 15213294 15336539 19035177 17217047 17649720 17869043 19075265 16330433 16891316 15622746 9834237 16331271 11468182 19225113 16112521 12018890 19642359 15748426 17107899 16966277 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008064 Lipidoses Tamoxifen 3.2715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5516169303
MESH:D008113 Liver Neoplasms arsenic trioxide 7.7414682389
MESH:D008113 Liver Neoplasms Tamoxifen 7.7416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.1420377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2417365036
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9811798837 19825857
MESH:D008175 Lung Neoplasms Tamoxifen 4.9818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.9811062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.4019196722 14580682 16827153 11731420 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.5316166281 16966607 18303189
MESH:D008654 Mesothelioma Selenium 6.5315107826
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2219417148 14977855 19549372 15949261 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2210525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4516624393 19769630 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.1110923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5419131511
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5415067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5415084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0817365031 17975199 17322281 15814490
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3011780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3016712894 8653321 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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