AutismKB 2.0

Annotation Detail for LATS2


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Basic Information Top
Gene Symbol:LATS2 ( FLJ13161,KPM )
Gene Full Name: LATS, large tumor suppressor, homolog 2 (Drosophila)
Band: 13q12.11
Quick LinksEntrez ID:26524; OMIM: 604861; Uniprot ID:LATS2_HUMAN; ENSEMBL ID: ENSG00000150457; HGNC ID: 6515
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
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Related Diseases/Disorders Top
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Desease IDDesease Name
1831Prostate cancer
1860Brain tumor
1944Breast cancer
2066Lung cancer
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LATS2 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of LATS2 mRNAincreases expression 20458559
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of LATS2 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LATS2 mRNAdecreases expression 20018196
19150397
C006780 bisphenol A bisphenol A affects the expression of LATS2 mRNAaffects expression 20170705
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LATS2 mRNAaffects expression 17484886
C014347 decitabine decitabine affects the methylation of LATS2 promoteraffects methylation 17049657
C014347 decitabine [decitabine affects the methylation of LATS2 promoter] which affects the expression of LATS2 mRNAaffects expression|affects methylation 17049657
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001254 Astrocytoma marker/mechanism 17049657
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9516206674
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.3517123778
MESH:D001943 Breast Neoplasms decitabine 2.3518320071 19208741
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1416227642 16124888 15673190 16097048 15721981 3786805 15700767 18705752 16011737 16192424 16050911 10355542
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.743084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7415553829 14691202 11135700 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7418788625
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6320501625
MESH:D015179 Colorectal Neoplasms decitabine 2.6318981723
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9711739529 14550746 16177239 19923254 17522070 19164858 17906064 2444490 18071297 19420014 18713872 10663392 14725611 10774834 15968718 16393943 11421492 12540782 19085960 11743745 16781746 12392966 19416960 12958197 11287661 12594235 19739265 16485898 11461765 17562736 12705907 11529661 10915739 19370779 16081117 15619225 16109766 12153990 11834606 16227642 14986274
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9710092053 10915739 7179309 9327722 3732212 4309450 6884620 19085960 11566570 21278145 3786805 17522070 7120509 7440962 6623471 15968718 19336974 2869522 15027814 16227642 15998439 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.5619294695
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6612903497
MESH:D005234 Fatty Liver arsenic trioxide 8.8215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.8212631006 16045604 12795759 16239168 15959796 61145 19224547 17595544
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8118705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006258 Head and Neck Neoplasms decitabine 3.6619215824
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219110552 19900420
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007248 Infertility, Male decitabine 3.3817581917
MESH:D007333 Insulin Resistance bisphenol A 3.4616393666
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007938 Leukemia arsenic trioxide 6.8615070760
MESH:D007938 Leukemia decitabine 6.8619235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.5419077051
MESH:D007951 Leukemia, Myeloid decitabine 10.5418454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.1320471514 16467208 17050201 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.1318460780 18704418 19010910 18206229 17679729 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9118055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3819035177 16112521 9834237 12018890 16823087 16331271 19642359 19225113 17712046 16966277 19075265 17869043 16891316 16330433 15213294 17217047 12712474 11468182 17107899 11161223 17649720 15336539 12679006 15748426 15622746
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9411408273 17334410 16239168 16221502 11903743 21278145 16943688 17174718 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7517525996 14716496 18418968 17869086 17976157 16136751 15730626 17481882 18429990 17698563 20821823 18277467 15673190 18395914 12586293 15931870 12741479 18054572 15876570 17761835 15996030 16015684 18205269 17557913 11481614 15370692 17640975 16097048 15650968 15925388 12958196 17922224 16116963 18006644 15893842 17714472 12667390 17805973 16027843 16638106 18317297 12389079 13678700 17823541 17565644 17708605 14724832 15818738 18156304 14748882 12546737 18412020 12632512 17900296 16192424 12898905 17631135 14512876 12445421 18376398 10355542 12649538 18279442 15338365 15959796 12632514 17721639 18472332 17766677 12666154 18263696 18472094 16011737 16248980 15052691 12445418 15123356 18210741 15362042 14620537 18339082 18251166 18187930 16033810 14716833 15057751 17944888 12609069 18705752 18395095 18420326 18481824 18166357
MESH:D008107 Liver Diseases Acetaminophen 4.0912587719 12969438 11587558 19784758 16611625 19460945 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0916246199 15830285 17285989 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.3116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.3116899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9214682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.9219294768
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.5320377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.5312014681 15583823
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3817365036
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D008223 Lymphoma decitabine 3.6119470736
MESH:D008545 Melanoma decitabine 2.2716505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2718303189 16966607 16166281
MESH:D009101 Multiple Myeloma arsenic trioxide 8.0211468182 19417148 14977855 19549372 15949261
MESH:D009101 Multiple Myeloma decitabine 8.0218172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.9816882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 7.9819157545 16882708 19010910 18608210
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009369 Neoplasms decitabine 2.8317925555 19116145 19470736
MESH:D009421 Nervous System Malformations bisphenol A 4.3016427766 11399458
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2319769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms decitabine 5.2319331143 19259094
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6815580305
MESH:D010190 Pancreatic Neoplasms decitabine 5.6819294695
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2510923243
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.3510548101
MESH:D055728 Primary Myelofibrosis decitabine 5.0917616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2819131511
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2816740699
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1117322281 17365031 15814490 17975199
MESH:D012208 Rhabdomyosarcoma decitabine 4.7119155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6217007042
MESH:D013274 Stomach Neoplasms decitabine 2.6219037991
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816045194 16684133
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.0319014326
MESH:D013964 Thyroid Neoplasms decitabine 8.0317967635
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.5512845720 11780464 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.5517616700 19087683
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
MESH:D014604 Uveal Neoplasms decitabine 5.3617785578
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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