AutismKB 2.0

Annotation Detail for AATF


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Basic Information Top
Gene Symbol:AATF ( CHE-1,CHE1,DED )
Gene Full Name: apoptosis antagonizing transcription factor
Band: 17q12
Quick LinksEntrez ID:26574; OMIM: 608463; Uniprot ID:AATF_HUMAN; ENSEMBL ID: ENSG00000108270; HGNC ID: 19235
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signalling by NGF
Pathway IDPathway Name
200191Regulation of retinoblastoma protein
No data
Pathway IDPathway Name
500609NRAGE signals death through JNK
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2051Leukemia
2053Colon cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AATF mRNAaffects expression 16483693
D003474 Curcumin Curcumin results in decreased expression of AATFdecreases expression 18462866
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of AATF mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of AATF mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AATF mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of AATF mRNAincreases expression 16174780
D005419 Flavonoids Flavonoids results in decreased expression of AATF mRNAdecreases expression 18035473
D012643 Selenium Selenium results in increased expression of AATF mRNAincreases expression 19244175
C009250 sevoflurane sevoflurane affects the expression of AATF mRNAaffects expression 15967596
D013629 Tamoxifen Tamoxifen affects the expression of AATF mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AATF mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.4617887948
MESH:D000544 Alzheimer Disease Curcumin 2.6615590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7816807698
MESH:D050197 Atherosclerosis Curcumin 3.4518704882
MESH:D001327 Autoimmune Diseases Curcumin 4.8019761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D002545 Brain Ischemia Curcumin 4.6716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1617596214
MESH:D001943 Breast Neoplasms Curcumin 1.8916243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms Tamoxifen 1.8919289846 15565566 20065188 19155303 16818667 18629630 19103187 19084267 18997820 20544844 16273361 19142967 19059307 11161223 19244106 19011961 17242785 15668708 18425577 20135344 17440819 19200415 18855134 19189210 19066611 17261762 18984771 19221464 16202921 17049068 20005174 19189212 18821012 17893378 18351453 19487384 21152245 18815881 16873071 19288272 20859285 19410462 20390343 21138602 19115204
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002277 Carcinoma Curcumin 8.9318593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8416924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0418414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8218462866
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 16120746 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0511677210 17110522 16919318 17333356 16105132 15861022 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 8697196 15668235 16354765 12621046
MESH:D003092 Colitis Curcumin 10.7118200517 16782535 16804969
MESH:D003092 Colitis Selenium 10.7117936198
MESH:D003103 Coloboma Curcumin 4.7918809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5316340194 19359593
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 5.2018497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.5718403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5717107852
MESH:D003928 Diabetic Nephropathies Curcumin 9.7818204486
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.7819279558
MESH:D056486 Drug-Induced Liver Injury Selenium 3.9715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004381 Duodenal Ulcer Curcumin 4.3317351913
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.9019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1916202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Curcumin 14.6219297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.6215345470
MESH:D005234 Fatty Liver Tamoxifen 14.6219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Curcumin 9.8318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8320067830
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0018462866
MESH:D005909 Glioblastoma Curcumin 3.6217596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8118829502 18462866
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2016120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.3517701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 15340226 16959395 18606429 16354765
MESH:D006937 Hypercholesterolemia Curcumin 4.2918704882
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Curcumin 12.9417151092 18403477 16956363
MESH:D007249 Inflammation Flavonoids 12.9417296493
MESH:D007249 Inflammation Tamoxifen 12.9419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.9412200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2918200517 18596194
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007414 Intestinal Neoplasms Curcumin 4.4510783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2418625569
MESH:D007859 Learning Disorders sevoflurane 5.0819212262
MESH:D007889 Leiomyoma Curcumin 4.8318555241
MESH:D007938 Leukemia Curcumin 3.3418462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4516106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.0416106398
MESH:D008064 Lipidoses Tamoxifen 3.3215342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.6417355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6412878042
MESH:D008107 Liver Diseases Curcumin 2.6616956363
MESH:D008113 Liver Neoplasms Tamoxifen 4.6516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008175 Lung Neoplasms Curcumin 3.5618462866 16243823 19359593
MESH:D008175 Lung Neoplasms Tamoxifen 3.5618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5611884234 19555203
MESH:D008223 Lymphoma Curcumin 3.7518462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0016173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.5315318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5319196723 11731420 16827153 14580682 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Curcumin 3.5717885582 18462866
MESH:D008545 Melanoma Tamoxifen 3.5719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008569 Memory Disorders Curcumin 10.9117263510
MESH:D008569 Memory Disorders sevoflurane 10.9119212262
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D009101 Multiple Myeloma Curcumin 3.6819372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.2617962980
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009361 Neoplasm Invasiveness Curcumin 4.6518495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 12.1312497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 12.1319189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009423 Nervous System Neoplasms Curcumin 6.0118462866
MESH:D009765 Obesity Curcumin 2.7919297423
MESH:D010024 Osteoporosis Curcumin 3.6118719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8819020741 18462866
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0019401701 19196508 17440100
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Curcumin 3.3418156803 18226269 12497104 10851300 18769126 15129424 11398177
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3415067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011656 Pulmonary Emphysema Curcumin 4.7619168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2810666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012509 Sarcoma Curcumin 4.3418462866
MESH:D018805 Sepsis Curcumin 4.2818389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D013276 Stomach Ulcer Curcumin 3.7319188055 16631530
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.5318593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5317572228 16712894 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 5.6018462866
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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