AutismKB 2.0

Annotation Detail for GDF2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GDF2 ( BMP-9,BMP9 )
Gene Full Name: growth differentiation factor 2
Band: 10q11.22
Quick LinksEntrez ID:2658; OMIM: 605120; Uniprot ID:GDF2_HUMAN; ENSEMBL ID: ENSG00000128802; HGNC ID: 4217
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200126ALK1 signaling events
Pathway IDPathway Name
P00052TGF-beta signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GDF2 mRNAincreases expression 18648102
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of GDF2 mRNAdecreases expression 15982314
C103303 alitretinoin alitretinoin results in decreased expression of GDF2 mRNAdecreases expression 15982314
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GDF2 mRNAaffects expression 17484886
D008070 Lipopolysaccharides Triclosan inhibits the reaction [Lipopolysaccharides results in increased expression of GDF2 mRNA]decreases reaction|increases expression 20507366
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GDF2 mRNAaffects binding|decreases expression|increases activity 19710929
D015474 Isotretinoin Isotretinoin results in increased expression of GDF2 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin metabolite results in decreased expression of GDF2 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of GDF2 mRNAdecreases expression 15982314
D014260 Triclosan Triclosan inhibits the reaction [Lipopolysaccharides results in increased expression of GDF2 mRNA]decreases reaction|increases expression 20507366
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 4.8218769834
MESH:D000015 Abnormalities, Multiple Isotretinoin 5.1818769834
MESH:D017486 Acneiform Eruptions Isotretinoin 6.6016232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.8016185265 18769834
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.7918653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 9.7918653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.6719483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.6716197459 16206674
MESH:D001943 Breast Neoplasms alitretinoin 2.4816344269
MESH:D001943 Breast Neoplasms Tretinoin 2.4816873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0415673190 16124888 16227642 10355542 15700767 16011737 16192424 16097048 15721981 18705752 3786805 16050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.747296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7418788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.741917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 5.2411237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.2416051514 16096774
MESH:D002386 Cataract Tretinoin 3.2017460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.897505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.359022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tretinoin 2.749407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D000013 Congenital Abnormalities Triclosan 5.3219283420
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.1218769834 9879862
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.1216925845 9125849 17551590 14991402 10589399 9224671 8800419 9142499 9664655 9211117
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0614531868 12868966 2524372 8156756 8970840 18759878 11298694 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.0518692083 7440962 18289764 11289319 16192314 6679447 9653073 18648102 6482804 8291058 1440618 9328219 9022650
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0519336974 16177239 7120509 7440962 11566570 4309450 15027814 15968718 7179309 21278145 3786805 17522070 10092053 10915739 3732212 2869522 6884620 9327722 6623471 19085960 16227642 15998439
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004489 Edema, Cardiac Tretinoin 4.7818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2316569247
MESH:D019446 Endotoxemia Lipopolysaccharides 4.6815821434 15328337 17637181
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tretinoin 3.739664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.3719224547 12631006 16045604 12795759 17595544 15959796 16239168 61145
MESH:D005234 Fatty Liver pirinixic acid 8.3720131406 19236843
MESH:D005334 Fever Lipopolysaccharides 4.219205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6818705752
MESH:D005355 Fibrosis Tretinoin 9.6817994277
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9914991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5816366002
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.036705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.0319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.2518467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Tretinoin 3.3716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007248 Infertility, Male Triclosan 4.5520821571
MESH:D007249 Inflammation Lipopolysaccharides 6.1717237260 17255318 12878042 17963957 9205823
MESH:D007249 Inflammation Triclosan 6.179584910 20507366
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8517255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 4.1117551590 15992940
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.9216144296
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.146582329
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2819075265 17294898 16331271 17361223 19225113 16788101 16766008 17649720 17301526 17712046 19029980 17339181 15748426 17217047 16935935 16891316 16140955 16823087 12679006 19035177 17368321 19642359 17506722 17107899 9834237
MESH:D007970 Leukopenia Lipopolysaccharides 4.9815821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9116943688 21278145 17157831 11903743 17334410 17174718 16239168 16221502 11408273
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1412898905 18420326 12632514 16097048 17557913 16116963 14748882 16011737 14512876 18205269 16136751 17721639 17869086 18317297 18472332 15959796 12389079 15893842 17481882 10355542 12649538 12586293 12445418 14724832 15673190 18187930 17698563 11481614 18277467 13678700 18472094 12741479 18395914 15362042 14620537 18054572 18006644 18339082 15730626 12445421 15925388 20821823 12546737 15650968 17714472 12958196 15931870 17766677 15370692 17525996 18376398 18481824 18251166 18395095 18412020 14716833 12666154 15052691 17922224 17944888 16638106 12609069 17823541 18705752 15818738 15057751 14716496 16027843 16192424 15996030 15338365 18263696 18210741 18279442 17761835 16033810 17708605 18418968 17805973 17565644 12632512 16015684 17631135 18429990 16248980 18166357 18156304 15123356 15876570 12667390 17976157 17640975 17900296
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.1412878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1415474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.1418397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1217285989 15830285 15720792 16964402 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8814706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6619294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.6616377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.326587162 598648 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3212014681 15583823
MESH:D055370 Lung Injury Lipopolysaccharides 4.2621114838
MESH:D008175 Lung Neoplasms alitretinoin 3.2516413115
MESH:D008175 Lung Neoplasms Isotretinoin 3.2515899809
MESH:D008325 Mammary Neoplasms, Experimental Triclosan 4.3215358634
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Isotretinoin 3.8217237267
MESH:D008545 Melanoma Tretinoin 3.8216752155
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms alitretinoin 8.8816946489
MESH:D009369 Neoplasms pirinixic acid 8.8817405874
MESH:D009369 Neoplasms Tretinoin 8.8816946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.029125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.656679447
MESH:D009436 Neural Tube Defects Tretinoin 7.659142499
MESH:D009447 Neuroblastoma Isotretinoin 4.1417368321
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Tretinoin 3.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5215976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011014 Pneumonia Lipopolysaccharides 4.8411605937 12224865
MESH:D017499 Porokeratosis alitretinoin 6.3216144296
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 5.1718769834
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011596 Psychomotor Disorders Isotretinoin 6.2018769834
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8610835634
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.6916467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3615821434
MESH:D013959 Thyroid Diseases Triclosan 6.3019910387
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.666582329 1399818 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms Tretinoin 7.6617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.348074119
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved