AutismKB 2.0

Annotation Detail for GREM1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GREM1 ( CKTSF1B1,DAND2,DRM,GREMLIN,IHG-2,MGC126660 )
Gene Full Name: gremlin 1
Band: 15q13.3
Quick LinksEntrez ID:26585; OMIM: 603054; Uniprot ID:GREM1_HUMAN; ENSEMBL ID: ENSG00000166923; HGNC ID: 2001
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200123BMP receptor signaling
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1746Hypertension, Pulmonary
1848Embryoma
1904Diabetes mellitus
2024Basal cell carcinoma
2032Kidney disease
Desease Name
nonsyndromic cleft lip with or without cleft palate
DEVELOPMENTAL
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GREM1 mRNAincreases expression 19933214
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of GREM1 mRNA]affects expression|affects reaction 19414516
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GREM1 mRNAincreases expression 18648102
C459179 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]decreases reaction|increases expression 17975199
C459179 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in increased expression of GREM1 mRNA]decreases reaction|increases expression 17975199
C459179 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of GREM1 mRNAdecreases expression 17975199
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GREM1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of GREM1 mRNAdecreases expression 19128835
D017638 Asbestos, Crocidolite 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]decreases reaction|increases expression 17975199
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of GREM1 mRNAincreases expression 18687144
17975199
D017638 Asbestos, Crocidolite PD 98059 inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]decreases reaction|increases expression 17975199
D017638 Asbestos, Crocidolite U 0126 inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]decreases reaction|increases expression 17975199
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the localization of GREM1 proteinaffects localization 17975199
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of GREM1 mRNAincreases expression 17975199
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of GREM1 proteinincreases expression 17975199
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GREM1 mRNAincreases expression 15336504
D003345 Corticosterone Corticosterone results in decreased expression of GREM1 mRNAdecreases expression 15755911
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA]decreases reaction|increases expression 18200517
C014347 decitabine decitabine results in increased expression of GREM1 mRNAincreases expression 16367923
D003907 Dexamethasone Dexamethasone inhibits the reaction [BMP2 protein results in increased expression of GREM1 mRNA]decreases reaction|increases expression 15268896
D003907 Dexamethasone Dexamethasone inhibits the reaction [BMP4 protein results in increased expression of GREM1 mRNA]decreases reaction|increases expression 15268896
D003907 Dexamethasone Dexamethasone inhibits the reaction [BMP6 protein results in increased expression of GREM1 mRNA]decreases reaction|increases expression 15268896
D002117 Calcitriol Calcitriol results in decreased expression of GREM1 mRNAdecreases expression 16002434
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of GREM1 mRNAaffects cotreatment|decreases expression 17404688
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of GREM1 mRNAincreases expression 17616710
C093973 PD 98059 PD 98059 inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]decreases reaction|increases expression 17975199
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of GREM1 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone Progesterone results in decreased expression of GREM1 mRNAdecreases expression 17404688
C004648 testosterone enanthate testosterone enanthate affects the expression of GREM1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GREM1 mRNAincreases expression 20067830
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GREM1 mRNAincreases expression 18691609
19933214
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNAincreases expression 18200517
C113580 U 0126 U 0126 inhibits the reaction [Asbestos, Crocidolite results in increased expression of GREM1 mRNA]decreases reaction|increases expression 17975199
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D000168 Acrocephalosyndactylia U 0126 5.3617694057
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3019825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.3011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.693712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2716835633
MESH:D019973 Alcohol-Related Disorders Curcumin 4.9817887948
MESH:D000544 Alzheimer Disease Curcumin 2.5915590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D001169 Arthritis, Experimental Dexamethasone 3.4717659584
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7116807698
MESH:D050197 Atherosclerosis Curcumin 3.2618704882
MESH:D001327 Autoimmune Diseases Curcumin 4.3819761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9111289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.6216206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2317868700
MESH:D001930 Brain Injuries Progesterone 4.1515665606 15380490 15845082
MESH:D002545 Brain Ischemia Curcumin 4.2216770732
MESH:D001932 Brain Neoplasms Curcumin 3.8417596214
MESH:D001943 Breast Neoplasms Calcitriol 2.9111237771
MESH:D001943 Breast Neoplasms Curcumin 2.9119250217 18593918 18462866 16243823
MESH:D001943 Breast Neoplasms decitabine 2.9118320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 2.9119861407 12948864 17261762 17289903 14630087 17018787 16675129 18497071
MESH:D001943 Breast Neoplasms Progesterone 2.9117614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9120435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2211589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002277 Carcinoma Curcumin 7.9918593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9916835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.483581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.4816217749 15073043 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.4816924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9418414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7719014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0212490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.4911237771
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.4918462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.4919215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.417505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.4118566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.0619486331 9022650
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0615668235 15340226 12621046 16354765 8697196
MESH:D003092 Colitis Curcumin 9.5918200517 16804969 16782535
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 9.5918200517 16867261 16474422 17936198 16804969 17991707 11698051 18023891 16782535
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4117276891
MESH:D003103 Coloboma Curcumin 4.4518809619
MESH:D003110 Colonic Neoplasms Curcumin 5.8316340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 5.8317616700
MESH:D003110 Colonic Neoplasms Dexamethasone 5.8315824018
MESH:D015179 Colorectal Neoplasms marker/mechanism 18084292
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5620501625
MESH:D015179 Colorectal Neoplasms decitabine 2.5618981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9617141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.7918497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7510525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.7517728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7510048152 15322242 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9915213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.6812868966 14531868 18759878 11906362 8156756 2524372 11298694 8970840
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.6812438553
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.393621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.3218403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D003928 Diabetic Nephropathies Curcumin 8.7218204486
MESH:D003928 Diabetic Nephropathies Estradiol 8.7219279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3817187935
MESH:D003967 Diarrhea Dexamethasone 3.597237001
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.597440962 9022650 16192314 18289764 8291058 18692083 1440618 9653073 6679447 9328219 6482804 18648102 11289319
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D004381 Duodenal Ulcer Curcumin 3.9417351913
MESH:D004485 Eczema Dexamethasone 4.3512438553
MESH:D004487 Edema Dexamethasone 6.5419703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 8.9515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.9517692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0119294695
MESH:D016889 Endometrial Neoplasms Estradiol 2.9111473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 8.6016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.6010568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.153581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.1512903497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.1515264214 15623463 15547733 15150132 15878914 15547721 16510608 16805852 16704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver arsenic trioxide 7.7315073043
MESH:D005234 Fatty Liver Curcumin 7.7319297423
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Curcumin 14.3118705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.3120067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 14.3117994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1516904648
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5818462866
MESH:D005909 Glioblastoma Curcumin 3.4017596214
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.7618829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 7.7619215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.416705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7815340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9317701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.037520565
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6417440010
MESH:D019584 Hot Flashes Estradiol 3.6517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.948697196 16354765 15340226 18606429 16959395
MESH:D006937 Hypercholesterolemia Curcumin 3.9518704882
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Dexamethasone 5.1117042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1118850075 18670907
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2915869954
MESH:D007248 Infertility, Male decitabine 3.1317581917
MESH:D007249 Inflammation Curcumin 11.5318403477 16956363 17151092
MESH:D007249 Inflammation Dexamethasone 11.538960868 11099482
MESH:D007249 Inflammation Progesterone 11.5315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.5312878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.5418200517 18596194
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.5418200517
MESH:D007333 Insulin Resistance Estradiol 2.8916627594 16393666
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.5017994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.1210783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.919022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007674 Kidney Diseases Estradiol 2.5215618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.066582329
MESH:D007680 Kidney Neoplasms Estradiol 7.0615610895
MESH:D007889 Leiomyoma Curcumin 4.4718555241
MESH:D007938 Leukemia arsenic trioxide 10.2515070760
MESH:D007938 Leukemia Curcumin 10.2518462866
MESH:D007938 Leukemia decitabine 10.2518980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.4212560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.4216106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 19.0416972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 19.0416972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 19.0416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.2519077051
MESH:D007951 Leukemia, Myeloid decitabine 9.2519117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9216467208 19850784 16968895 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9219010910 19387464 17679729 18206229 18460780 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3618055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1411161223 17869043 19225113 19075265 16331271 15213294 15336539 16891316 15748426 15622746 19035177 12712474 12679006 11468182 19642359 17712046 12018890 16112521 17217047 9834237 16330433 17649720 16966277 16823087 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.3616882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.3616106398
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.139327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 4.8818006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 4.8816718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8812878042
MESH:D008107 Liver Diseases Curcumin 2.5916956363
MESH:D008113 Liver Neoplasms arsenic trioxide 4.3014682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3016984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.40598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.4020377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.4012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2615213294
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.9117365036
MESH:D008175 Lung Neoplasms arsenic trioxide 4.7819825857 11798837
MESH:D008175 Lung Neoplasms Curcumin 4.7816243823 19359593 18462866
MESH:D008175 Lung Neoplasms Dexamethasone 4.7815824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7819555203 11884234
MESH:D008223 Lymphoma Curcumin 7.5118462866
MESH:D008223 Lymphoma decitabine 7.5119470736
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5816173963
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 9.7012807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.7016891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.7017203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.3819453300
MESH:D008545 Melanoma Curcumin 3.5318462866 17885582
MESH:D008545 Melanoma decitabine 3.5316505122 17785578
MESH:D008569 Memory Disorders Curcumin 4.0517263510
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1416966607 18303189 16166281
MESH:D009101 Multiple Myeloma arsenic trioxide 16.6619549372 19417148 14977855 11468182 15949261
MESH:D009101 Multiple Myeloma Curcumin 16.6619372569
MESH:D009101 Multiple Myeloma decitabine 16.6618172295
MESH:D009101 Multiple Myeloma Dexamethasone 16.6615867202 16118317 15744524
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8117962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 12.0416882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 12.0419157545 16882708 19010910 18608210
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 12.049809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1916810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.9716624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.9718495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.433581430
MESH:D009369 Neoplasms decitabine 2.6619470736 19116145 17925555
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.4312497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6217289903
MESH:D009421 Nervous System Malformations Estradiol 9.1111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1114600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.5218462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.016679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.0110525206
MESH:D009765 Obesity Curcumin 2.7219297423
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.324026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010024 Osteoporosis Curcumin 3.4018719352
MESH:D010051 Ovarian Neoplasms arsenic trioxide 18.4419769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Curcumin 18.4418462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 18.4419331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 18.4419401270
MESH:D010051 Ovarian Neoplasms Progesterone 18.4417393432 16525653
MESH:D010051 Ovarian Neoplasms U 0126 18.4416211241
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.5015580305
MESH:D010190 Pancreatic Neoplasms Curcumin 8.5019401701 19196508 17440100
MESH:D010190 Pancreatic Neoplasms decitabine 8.5019294695
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.1017698068
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010235 Paraganglioma arsenic trioxide 4.0619927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.7810923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4821297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0811399792 11896295 11222880 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.6217616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1219131511
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1215754350 16289102 18247401 12479363 16644109
MESH:D011471 Prostatic Neoplasms Curcumin 2.1218226269 11398177 10851300 18769126 15129424 12497104 18156803
MESH:D011471 Prostatic Neoplasms Estradiol 2.1216740699
MESH:D011656 Pulmonary Emphysema Curcumin 4.4319168576
MESH:D011658 Pulmonary Fibrosis marker/mechanism 17975199
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9917365031 17322281 15814490 17975199
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 8.9618379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 8.9618379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.3019155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8218045962
MESH:D012509 Sarcoma Curcumin 4.0218462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8516646077
MESH:D018805 Sepsis Curcumin 3.9818389075
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.428532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4216192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.1715862959 16503802
MESH:D013272 Stomach Diseases Dexamethasone 4.2115472012
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4317007042
MESH:D013274 Stomach Neoplasms decitabine 3.4319037991
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.4312958204 17575124
MESH:D013276 Stomach Ulcer Curcumin 7.2019188055 16631530
MESH:D013276 Stomach Ulcer Dexamethasone 7.2015138204
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.516587162 6582329 3712494 1399818 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.5119014326
MESH:D013964 Thyroid Neoplasms decitabine 11.5117967635
MESH:D013978 Tibial Fractures Estradiol 4.5819048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8515213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.628074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.6212973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Curcumin 11.6218593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.6219087683 17616700
MESH:D014565 Urogenital Neoplasms Curcumin 5.1618462866
MESH:D014604 Uveal Neoplasms decitabine 4.8117785578
MESH:D014605 Uveitis Dexamethasone 4.711336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26537
    • No data
    Releated disease ID Related disease Name
    PA446108Colorectal Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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