AutismKB 2.0

Annotation Detail for NAP1L5


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Basic Information Top
Gene Symbol:NAP1L5 ( DRLM )
Gene Full Name: nucleosome assembly protein 1-like 5
Band: 4q22.1
Quick LinksEntrez ID:266812; OMIM: 612203; Uniprot ID:NP1L5_HUMAN; ENSEMBL ID: ENSG00000177432; HGNC ID: 19968
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NAP1L5 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NAP1L5 proteinaffects expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NAP1L5 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of NAP1L5 mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NAP1L5 mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NAP1L5 mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of NAP1L5 mRNAaffects cotreatment|increases expression 16931933
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NAP1L5 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NAP1L5 mRNAaffects cotreatment|increases expression 17942748
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NAP1L5 mRNAaffects cotreatment|increases expression 16931933
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NAP1L5 mRNAaffects cotreatment|increases expression 16931933
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NAP1L5 mRNAaffects cotreatment|increases expression 17942748
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NAP1L5 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NAP1L5 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of NAP1L5 mRNAaffects cotreatment|increases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.049612607
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.993786805 15721981 18705752 15673190 16192424 15700767 10355542 16227642 16097048 16124888 16011737 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.683084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6812907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6818788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.2019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2016105132 17333356 16919318 15861022 17681005 17110522 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615340226 15668235 8697196 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3915968718 16485898 16081117 19923254 14986274 19370779 19739265 10663392 16109766 17562736 17906064 16393943 11739529 2444490 16227642 11421492 19085960 12392966 12705907 12958197 11834606 12594235 16781746 11529661 16177239 12153990 12540782 15619225 11287661 19420014 19416960 19164858 10915739 17522070 11461765 10774834 11743745 18713872 18071297 14550746 14725611
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.397120509 16177239 11566570 10915739 3732212 2869522 7179309 17522070 10092053 4309450 6884620 3786805 15998439 19085960 6623471 9327722 15027814 19336974 16227642 21278145 15968718 7440962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Lamivudine 14.6215040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.6211462148
MESH:D004362 Drug Toxicity Zidovudine 14.6215040536
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2812631006 61145 15959796 16045604 12795759 19224547 16239168 17595544
MESH:D005234 Fatty Liver Cyclosporine 20.2819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2815345470
MESH:D005234 Fatty Liver Zidovudine 20.2818299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 16.0218705752
MESH:D005355 Fibrosis Cyclosporine 16.0212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0220067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 4.9012579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006509 Hepatitis B Lamivudine 5.2717703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.2715309715 12044531 15631357 16476009 15274664
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 16120746 15340226
MESH:D015658 HIV Infections Indinavir 16.2115388451 11141242 11363243
MESH:D015658 HIV Infections Lamivudine 16.2111141242 9296927 20032539 17530837
MESH:D015658 HIV Infections Saquinavir 16.2111141242 15388451
MESH:D015658 HIV Infections Zidovudine 16.2120032539 11363243 17358032 11698656 11141242
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.1010903974 18776723 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0512371664
MESH:D007680 Kidney Neoplasms Zidovudine 8.0512579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.5820370541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8916239168 16221502 17334410 17174718 16943688 11408273 21278145 11903743 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3317640975 18054572 12632512 17805973 15650968 17761835 12667390 15052691 18412020 18472332 12546737 15931870 12958196 16097048 16027843 12389079 18317297 17698563 18376398 15925388 17714472 14620537 12898905 15673190 18156304 16136751 17721639 18006644 12445421 14716496 18395095 17900296 18429990 17869086 17525996 12666154 18279442 14748882 18420326 14512876 18481824 17481882 18705752 12649538 11481614 17823541 18251166 18210741 18395914 17708605 10355542 16248980 16033810 17922224 17631135 16015684 18263696 18472094 15893842 12445418 12741479 15730626 15123356 12632514 13678700 15370692 14716833 18277467 15996030 16638106 18418968 15818738 15362042 15338365 17557913 12586293 18187930 17944888 14724832 18205269 12609069 17976157 16116963 15876570 17565644 20821823 18166357 17766677 16192424 15959796 18339082 16011737 15057751
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Acetaminophen 4.0319460945 11587558 19784758 16611625 19014921 12587719 12969438 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0316246199 17285989 15830285 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9514706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.742125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7419294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.418603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4112151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5814755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5811884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 3.5818800350
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.1017358032
MESH:D009164 Mycobacterium Infections Indinavir 5.6821442799
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311399792 11118676 11896295 11222880
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.779296927
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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