Gene Symbol:	GFAP ( FLJ45472 )
Gene Full Name:	glial fibrillary acidic protein
Band:	17q21.31
Quick Links	Entrez ID:2670; OMIM: 137780; Uniprot ID:GFAP_HUMAN; ENSEMBL ID: ENSG00000131095; HGNC ID: 4235
Relate to Another Database:	SFARIGene; denovo-db

Desease ID	Desease Name
	Nervous system diseases
	Neurodegenerative diseases
H00065	Alexander disease

Desease ID	Desease Name
1907	Depression
1983	Down syndrome
2045	Bipolar disorder
2124	Autistic disorder
2145	Subarachnoid hemorrhage
2221	Behavior disease
2242	Nervous system tumor

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C097240	15-deoxy-delta(12,14)-prostaglandin J2	15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GFAP	increases expression	15254749
C014211	2,3,7,8-tetrachlorodibenzofuran	2,3,7,8-tetrachlorodibenzofuran affects the expression of GFAP mRNA	affects expression	18343893
C106538	abacavir	abacavir results in increased expression of GFAP protein	increases expression	19358275
D000535	Aluminum	Aluminum results in increased expression of GFAP protein	increases expression	16545059
D000535	Aluminum	Vitamin E inhibits the reaction [Aluminum results in increased expression of GFAP protein]	decreases reaction\|increases expression	16545059
C104223	aluminum lactate	aluminum lactate affects the localization of GFAP protein	affects localization	12397369
D000641	Ammonia	Ammonia results in decreased expression of GFAP mRNA	decreases expression	20217200
D000641	Ammonia	IL1B protein promotes the reaction [Ammonia results in decreased expression of GFAP mRNA]	decreases expression\|increases reaction	20217200
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of GFAP mRNA	decreases expression	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of GFAP protein	decreases expression	16483693
D000661	Amphetamine	Amphetamine results in increased expression of GFAP protein	increases expression	15814102
D000661	Amphetamine	Amphetamine results in increased expression of GFAP mRNA	increases expression	15183010 20223277
D000661	Amphetamine	Amphetamine results in increased expression of GFAP protein	increases expression	15183010
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GFAP mRNA	decreases expression	20127859
C006780	bisphenol A	bisphenol A results in increased expression of GFAP protein	increases expression	16684133 17210262 16860915
C006780	bisphenol A	Tamoxifen inhibits the reaction [bisphenol A results in increased expression of GFAP protein]	decreases reaction\|increases expression	16860915
D002211	Capsaicin	Capsaicin results in increased expression of GFAP mRNA	increases expression	18405923
D002211	Capsaicin	Capsaicin inhibits the reaction [IL6 protein results in increased expression of GFAP mRNA]	decreases reaction\|increases expression	19285962
D002330	Carmustine	Carmustine results in decreased expression of GFAP mRNA	decreases expression	15980968
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of GFAP mRNA	decreases expression	17452286
D003024	Clozapine	Clozapine results in decreased expression of GFAP protein	decreases expression	18585900
D003024	Clozapine	Clozapine results in increased expression of GFAP mRNA	increases expression	19441803
D003042	Cocaine	Cocaine results in increased expression of GFAP protein	increases expression	15814102
C009160	cyclonite	cyclonite results in increased expression of GFAP mRNA	increases expression	19417177
D003671	DEET	[DEET co-treated with Permethrin] results in increased expression of GFAP protein	affects cotreatment\|increases expression	11681848
D003671	DEET	DEET results in increased expression of GFAP protein	increases expression	11681848
D003976	Diazinon	Diazinon affects the expression of GFAP mRNA	affects expression	17452286
D004026	Dieldrin	Dieldrin promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein]	increases expression\|increases reaction	16809432
D004052	Diethylnitrosamine	Diethylnitrosamine affects the expression of GFAP mRNA	affects expression	20387270
D002117	Calcitriol	Calcitriol affects the expression of GFAP mRNA	affects expression	15138306
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of GFAP mRNA	affects expression	17555576
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GFAP mRNA	affects cotreatment\|decreases expression	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GFAP mRNA	affects cotreatment\|increases expression	17942748
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins affects the expression of GFAP protein	affects expression	16414080
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of GFAP mRNA	increases expression	17997286
D006861	Hydrogen Peroxide	Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in increased expression of GFAP mRNA]	decreases reaction\|increases expression	17997286
C081064	LY 231617	LY 231617 affects the expression of GFAP mRNA	affects expression	8915593
D018817	N-Methyl-3,4-methylenedioxyamphetamine	N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GFAP protein	increases expression	16489401
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of GFAP protein	increases expression	18155124
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein	increases expression	19199078
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	Dieldrin promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein]	increases expression\|increases reaction	16809432
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein]	decreases reaction\|increases expression	19199078
C091888	monoisoamyl-2,3-dimercaptosuccinate	monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of GFAP mRNA	decreases expression	19615344
C510003	nordy	nordy results in increased expression of GFAP mRNA	increases expression	18232056
C510003	nordy	nordy results in increased expression of GFAP protein	increases expression	18232056
D010424	Pentobarbital	Pentobarbital affects the expression of GFAP mRNA	affects expression	1317493
D026023	Permethrin	Permethrin results in increased expression of GFAP protein	increases expression	14555407
D026023	Permethrin	[DEET co-treated with Permethrin] results in increased expression of GFAP protein	affects cotreatment\|increases expression	11681848
D026023	Permethrin	Permethrin results in increased expression of GFAP protein	increases expression	11681848
D010622	Phencyclidine	Phencyclidine results in increased expression of GFAP mRNA	increases expression	17266109
D011374	Progesterone	Progesterone affects the expression of GFAP mRNA	affects expression	10987130
C029658	propionic acid	propionic acid results in increased expression of GFAP protein	increases expression	16950524
C089730	rosiglitazone	[rosiglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of GFAP mRNA	affects binding\|decreases expression\|increases activity	18543250
D012643	Selenium	Selenium results in decreased expression of GFAP protein	decreases expression	18583539
C017947	sodium arsenite	sodium arsenite results in decreased expression of GFAP mRNA	decreases expression	19615344
D012965	Sodium Chloride	Sodium Chloride results in decreased expression of GFAP protein	decreases expression	16280599
D018038	Sodium Selenite	Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in increased expression of GFAP mRNA]	decreases reaction\|increases expression	17997286
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of GFAP mRNA	decreases expression	18209489
D013629	Tamoxifen	Tamoxifen affects the expression of GFAP mRNA	affects expression	17555576
D013629	Tamoxifen	Tamoxifen inhibits the reaction [bisphenol A results in increased expression of GFAP protein]	decreases reaction\|increases expression	16860915
C021751	tanshinone	tanshinone results in increased expression of GFAP mRNA	increases expression	16955220
C021751	tanshinone	tanshinone results in increased expression of GFAP protein	increases expression	16955220
D013726	Terbutaline	Terbutaline results in increased expression of GFAP protein	increases expression	14610225
D013739	Testosterone	Testosterone affects the expression of GFAP mRNA	affects expression	10987130
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GFAP mRNA	affects expression	18343893
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GFAP mRNA	affects cotreatment\|decreases expression	17942748
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GFAP mRNA	affects cotreatment\|increases expression	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GFAP mRNA	decreases expression	19490992
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of GFAP protein	decreases expression	8372046
D014050	Toluene	Toluene results in increased expression of GFAP protein	increases expression	10987130
D014212	Tretinoin	Tretinoin results in decreased expression of GFAP protein	decreases expression	16944780
D014635	Valproic Acid	Valproic Acid results in decreased expression of GFAP protein	decreases expression	18585900
D014810	Vitamin E	Vitamin E inhibits the reaction [Aluminum results in increased expression of GFAP protein]	decreases reaction\|increases expression	16545059
C022189	zonisamide	zonisamide inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein]	decreases reaction\|increases expression	19199078

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D000008	Abdominal Neoplasms		Tamoxifen	4.00	14745880
MESH:D000014	Abnormalities, Drug-Induced		Capsaicin	16.06	18926900
MESH:D000014	Abnormalities, Drug-Induced		Terbutaline	16.06	14610225
MESH:D000014	Abnormalities, Drug-Induced		Tetrachlorodibenzodioxin	16.06	14514962 15322242 11752688
MESH:D000014	Abnormalities, Drug-Induced		Valproic Acid	16.06	8875741
MESH:D000015	Abnormalities, Multiple		Valproic Acid	3.45	19490988
MESH:D000138	Acidosis		Ammonium Chloride	3.02	18287403
MESH:D000152	Acne Vulgaris		Ethinyl Estradiol	3.39	17505938
MESH:D058186	Acute Kidney Injury		Capsaicin	4.07	18460982
MESH:D000230	Adenocarcinoma		Benzo(a)pyrene	6.15	20127859 20464547
MESH:D000230	Adenocarcinoma		Ethinyl Estradiol	6.15	14692618
MESH:D000230	Adenocarcinoma		Methylnitrosourea	6.15	15688392 15113128
MESH:D000236	Adenoma		Benzo(a)pyrene	5.53	6695378
MESH:D000236	Adenoma		Diethylnitrosamine	5.53	6695378 10737359
MESH:D018248	Adenoma, Liver Cell		Diethylnitrosamine	8.27	19052882 19061943 17620307 17162532 16434500 18056438
MESH:D018248	Adenoma, Liver Cell		Tetrachlorodibenzodioxin	8.27	16835633
MESH:D000310	Adrenal Gland Neoplasms		sodium arsenite	4.15	15276417
MESH:D018246	Adrenocortical Adenoma		sodium arsenite	4.35	17306315 16712894
MESH:D000380	Agranulocytosis		Clozapine	4.53	14617031 12649775 16160616
MESH:D000382	Agricultural Workers' Diseases		Chlorpyrifos	7.40	17119214 16611668 11874814
MESH:D000382	Agricultural Workers' Diseases		Diazinon	7.40	16487989
MESH:D038261	Alexander Disease	marker/mechanism
MESH:D000505	Alopecia		Capsaicin	8.15	17569567
MESH:D000505	Alopecia		Tretinoin	8.15	15955085
MESH:D000544	Alzheimer Disease		Aluminum	4.45	10721010 17662457
MESH:D000544	Alzheimer Disease		rosiglitazone	4.45	19621015
MESH:D000550	Amblyopia		Valproic Acid	4.68	17688650
MESH:D019969	Amphetamine-Related Disorders		Amphetamine	5.52	16459022 15010207 18475255 16916582
MESH:D000686	Amyloidosis		Terbutaline	5.11	7986221
MESH:D000740	Anemia		Tetrachlorodibenzodioxin	2.48	11748828
MESH:D000855	Anorexia		Amphetamine	9.11	16084549 12183048 16101753 12005258
MESH:D000855	Anorexia		N-Methyl-3,4-methylenedioxyamphetamine	9.11	15146954
MESH:D000987	Antisocial Personality Disorder		Testosterone	5.31	7506515
MESH:D001008	Anxiety Disorders		Pentobarbital	7.82	18313124 11141031
MESH:D001008	Anxiety Disorders		Valproic Acid	7.82	17497229
MESH:D017544	Aortic Aneurysm, Abdominal		Benzo(a)pyrene	3.55	19183758
MESH:D001161	Arteriosclerosis		Ethinyl Estradiol	2.94	11256880
MESH:D001169	Arthritis, Experimental		Ethinyl Estradiol	6.04	15885639
MESH:D001169	Arthritis, Experimental		Tretinoin	6.04	16412693
MESH:D001172	Arthritis, Rheumatoid		Tretinoin	2.12	16292516

AutismKB 2.0

Annotation Detail for GFAP

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics