AutismKB 2.0

Annotation Detail for GFER


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Basic Information Top
Gene Symbol:GFER ( ALR,ERV1,HERV1,HPO,HPO1,HPO2,HSS )
Gene Full Name: growth factor, augmenter of liver regeneration
Band: 16p13.3
Quick LinksEntrez ID:2671; OMIM: 600924; Uniprot ID:ALR_HUMAN; ENSEMBL ID: ENSG00000127554; HGNC ID: 4236
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2233Cirrhosis
No data
No data
Desease Name
Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GFER mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of GFER mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GFER mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GFER mRNAaffects cotreatment|decreases expression 18164116
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GFER mRNAincreases expression 15336504
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GFER mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride GFER protein affects the susceptibility to Carbon Tetrachlorideaffects response to substance 14980112
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of GFER mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of GFER mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GFER mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GFER mRNAaffects cotreatment|decreases expression 20360939
D006861 Hydrogen Peroxide GFER protein affects the susceptibility to Hydrogen Peroxideaffects response to substance 14980112
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of GFER mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GFER mRNAincreases expression 18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GFER mRNAincreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.773712494
MESH:D000236 Adenoma beta-Naphthoflavone 11.7719389873
MESH:D000236 Adenoma Diethylnitrosamine 11.7710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.8617162532 19052882 17620307 19061943 16434500 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002252 Carbon Tetrachloride Poisoning therapeutic 15968720
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916192424 16227642 3786805 15673190 16124888 16011737 18705752 16097048 15721981 16050911 15700767 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7716705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.773581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7720432363 18788625 10737359 17173139 19394651 16288022 16807293 16878318 19107877 19701751 19383236 16502159 18785209 17761372 17162532 20514400 20101231 20727157 20007298 19919837 18056438 18506893 18691550 18210153 16681979 16935385 11831363 19539802 16830150 19208518 18494052 20214788 17428255 10672840 20084675 17138121 20935162 19052882 18971187 17978847 18978308 16569478 19519916 18393292 16698587 17055752 19418558 19171122 16540662 16328049 20524982 19335982 20512989 21159647 18665156 16779866 19822196 3084413 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.6316936243
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.087505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.087505956 17174075 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.8419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.8416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2719486331 9022650
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1612621046 8697196 15668235 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0111906362 8156756 14531868 18759878 2524372 12868966 8970840 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3417107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.519328219 6679447 18692083 16192314 6482804 18648102 11289319 1440618 18289764 8291058 9022650 9653073 7440962
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.5110915739 19085960 7179309 15968718 19336974 16227642 10092053 16177239 6884620 2869522 9327722 4309450 3786805 17522070 3732212 21278145 7120509 7440962 11566570 6623471 15027814 15998439
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.5119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1716714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.4115959796 61145 12795759 19224547 12631006 17595544 16045604 16239168
MESH:D005234 Fatty Liver Diethylnitrosamine 8.4121071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Carbon Tetrachloride 9.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3320067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.896705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.8919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 16959395 8697196 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007249 Inflammation Diethylnitrosamine 5.1718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1712878042 12200463
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.7510783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.6415369732
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.4416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.846582329
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1016766008
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9016943688 11903743 11408273 21278145 16239168 17174718 17157831 17334410 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9020032147 19638242 18665156 18407596 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3315730626 17525996 18412020 12632512 18395914 12667390 17869086 15650968 12632514 12958196 14716496 17900296 17557913 15893842 17481882 13678700 16136751 18205269 18339082 16192424 17805973 12586293 16248980 16097048 18251166 10355542 14748882 17721639 18277467 18279442 18472332 15959796 15925388 17565644 12898905 12741479 15123356 15996030 16638106 18263696 17761835 15052691 15931870 18429990 12666154 18156304 17698563 16027843 12389079 16116963 14620537 16011737 14512876 18317297 17708605 17976157 15818738 12445421 18472094 17640975 12649538 15876570 15362042 16033810 15673190 18418968 18006644 17631135 17922224 12445418 17823541 14724832 18376398 16015684 18187930 18420326 18054572 18166357 18210741 18395095 15338365 14716833 17766677 18705752 12546737 18481824 17714472 15057751 15370692 11481614 17944888 12609069 20821823
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2015720792 16246199 15830285 16964402 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2017034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute therapeutic 15968720
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.2021295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.2019294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.2020434301 18648771 19850985 19294768 20118626 21167192 18978307 12112319 2862719 15175105 20501860 19812893 16942905 18977376 19256749 19499222 15885732 21278145 20583210 12771043 19255062 20101389 19996281 19642983 19427195 18754104 19090486 20137499 9163691 19690152 20492335 20452335 10737359 19254457 2422723 19638242 20405173 19426721 19551842 21071580 18644402 19073162 19833225 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2016984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 19.77598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 19.7718164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.7715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.7718079962 18775883 18544905 3124819 16267830 18093689 19009564 17854601 18308698 16842330 19539802 19126423 19519916 17174075 21159647 18282651 19004024 17942915 18164116 18253720 2563599 9362446
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.7712151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.3020512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3019555203 11884234
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
OMIM:613076 MYOPATHY, MITOCHONDRIAL PROGRESSIVE, WITH CONGENITAL CATARACT, HEARING LOSS, AND DEVELOPMENTAL DELAY marker/mechanism
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.903581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.903581430 9029167
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.436482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 10.057296757
MESH:D010212 Papilloma Hydrogen Peroxide 10.0512065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311399792 11222880 11896295 11118676
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.9212065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.928532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.9216192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.563712494 6582329 7505956 1399818 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.567505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.218074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03147 - Flavin-Adenine Dinucleotide
No data
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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