AutismKB 2.0

Annotation Detail for GFRA1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GFRA1 ( DKFZp313E1012,DKFZp686J0156,FLJ10561,FLJ31546,GDNFR,GDNFRA,GFR-ALPHA-1,MGC23045,RET1L,RETL1,TRNR1 )
Gene Full Name: GDNF family receptor alpha 1
Band: 10q25.3
Quick LinksEntrez ID:2674; OMIM: 601496; Uniprot ID:GFRA1_HUMAN; ENSEMBL ID: ENSG00000151892; HGNC ID: 4243
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200058Signaling events regulated by Ret tyrosine kinase
No data
Pathway IDPathway Name
500087NCAM1 interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1709Parkinson disease
1944Breast cancer
2129Thyroid cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of GFRA1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GFRA1 mRNAaffects expression 16483693
D001205 Ascorbic Acid [Tretinoin co-treated with Ascorbic Acid] results in increased expression of GFRA1 mRNAaffects cotreatment|increases expression 16443354
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GFRA1 mRNAincreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of GFRA1 mRNAincreases expression 16474171
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of GFRA1 mRNAdecreases expression 15336504
D003520 Cyclophosphamide GFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D016572 Cyclosporine Cyclosporine results in decreased expression of GFRA1 mRNAdecreases expression 20106945
D004317 Doxorubicin GFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GFRA1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of GFRA1 mRNAdecreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of GFRA1 mRNAincreases expression 16474171
D000431 Ethanol Ethanol results in decreased expression of GFRA1 mRNAdecreases expression 15353170
D005472 Fluorouracil GFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D019833 Genistein Genistein results in increased expression of GFRA1 mRNAincreases expression 16474171
D007657 Ketone Bodies Ketone Bodies results in decreased expression of GFRA1 mRNAdecreases expression 16807920
D008701 Methapyrilene Methapyrilene results in decreased expression of GFRA1 mRNAdecreases expression 16393664
D017239 Paclitaxel GFRA1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D010269 Paraquat Paraquat results in increased expression of GFRA1 mRNAincreases expression 17077588
D010615 Phenacetin Phenacetin results in increased expression of GFRA1 mRNAincreases expression 17698508
D010634 Phenobarbital Phenobarbital results in increased expression of GFRA1 mRNAincreases expression 19270015
C030299 phenylhydrazine phenylhydrazine results in increased expression of GFRA1 mRNAincreases expression 17698508
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GFRA1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of GFRA1 mRNAincreases expression 18445702
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of GFRA1 mRNAincreases expression 16474171
D012402 Rotenone Rotenone results in decreased expression of GFRA1 mRNAdecreases expression 19013527
C446685 systhane systhane results in decreased expression of GFRA1 mRNAdecreases expression 16730040
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GFRA1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GFRA1 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of GFRA1 mRNAaffects binding|decreases expression 16214954
D014212 Tretinoin [Tretinoin co-treated with Ascorbic Acid] results in increased expression of GFRA1 mRNAaffects cotreatment|increases expression 16443354
D014212 Tretinoin [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GFRA1 mRNAaffects cotreatment|increases expression 17085092
D014212 Tretinoin Tretinoin results in increased expression of GFRA1 mRNAincreases expression 16604517
D014212 Tretinoin Tretinoin results in decreased expression of GFRA1 mRNAdecreases expression 17303670
C032910 triadimefon triadimefon results in decreased expression of GFRA1 mRNAdecreases expression 16730040
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.9317676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.936195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.9314514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 9.7118287403
MESH:D000138 Acidosis Ethanol 9.7111192467
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D000230 Adenocarcinoma Doxorubicin 9.7217418594
MESH:D000230 Adenocarcinoma Estradiol 9.7211473722
MESH:D000230 Adenocarcinoma Fluorouracil 9.7217638652
MESH:D000230 Adenocarcinoma Genistein 9.7211473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.9617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.9616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.9616835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5411874814
MESH:D000419 Albuminuria Doxorubicin 4.3221441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0915451039 15451040
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D000740 Anemia Fluorouracil 19.6515504547 16511603 17963324
MESH:D000740 Anemia Phenacetin 19.652444515
MESH:D000740 Anemia phenylhydrazine 19.652444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 19.6511748828
MESH:D000743 Anemia, Hemolytic Phenacetin 10.371949026 17082564 17698508
MESH:D000743 Anemia, Hemolytic phenylhydrazine 10.3717698508 17084956 17082564
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D000853 Anophthalmos Ethanol 4.5915513904
MESH:D001008 Anxiety Disorders Ethanol 3.8311141031
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.3715014928
MESH:D001169 Arthritis, Experimental Tretinoin 2.9416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.0819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.0812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.0816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4714601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.3615867366
MESH:D001862 Bone Resorption bisphenol A 3.6611985600
MESH:D001932 Brain Neoplasms Doxorubicin 3.6117150277
MESH:D001943 Breast Neoplasms Ascorbic Acid 6.7716443354
MESH:D001943 Breast Neoplasms bisphenol A 6.7717123778
MESH:D001943 Breast Neoplasms Cyclophosphamide 6.7718234424 12006526 11325840 18323546 17388661 16978400 17020986 15093573 15136595
MESH:D001943 Breast Neoplasms Doxorubicin 6.7716595493 16096432 15692762 18695136 11325840 16264153 16826403 15567936 16322301 19526202 15993339 15939500 17426702 15136595 18234424 15668708 16115903 18628466 17369602 15634643 16935488 18382427 17983394 15994142
MESH:D001943 Breast Neoplasms Estradiol 6.7717289903 18497071 14630087 16675129 17261762 19861407 12948864 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 6.7715136595 16595493 19217205 18608205 18357371 16110121 16557594
MESH:D001943 Breast Neoplasms Genistein 6.7716873071 17200150 16541309
MESH:D001943 Breast Neoplasms Paclitaxel 6.7711325840 16244791 16115903 16273361 18234424 15136595 18223236 18323546
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7720435547
MESH:D001943 Breast Neoplasms Tretinoin 6.7716443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3616813970
MESH:D002056 Burns Ethanol 4.4316374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002276 Carcinoid Tumor Doxorubicin 11.5816051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.5816051944
MESH:D002277 Carcinoma Fluorouracil 7.5917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 22.173084413
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 22.1719701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 22.1716234567 18059187 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 22.1716924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 22.1715289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 22.1717045692 18930000 16332177 16799960 17088986 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 22.1716924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 22.1716313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 22.171701930 20935162 20007298 6705139 17173139
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 22.171917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7617123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.6616152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 10.2816201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.2816201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.2818695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.206189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.2016757204 17066447 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.2016051514 16096774
MESH:D006332 Cardiomegaly Ethanol 6.4319332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4316120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.3817974986 17928571 16455267 18627295 16242529 17351982 16278810 16651473 17007740 16364871 17382496 15505089 17924179 16109756 15811867 16731534 16952015 17131338 15792986 17329180 16612575 17308081 15476868 16269455 17519947
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8716243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 3.1516332659
MESH:D002386 Cataract Acetaminophen 6.7810977129
MESH:D002386 Cataract Tretinoin 6.7817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.2420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.2412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.2418566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.034080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis Cyclosporine 7.2019486331
MESH:D002779 Cholestasis pirinixic acid 7.2019176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D002971 Cleft Lip Ethanol 3.4715513904
MESH:D002972 Cleft Palate Ethanol 13.3515513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 13.3512621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 13.359407595
MESH:D002972 Cleft Palate triadimefon 13.3516781842
MESH:D003092 Colitis Tretinoin 3.4817035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7016340194 17725105 17016597 15001691 17169374 16510598 18772588 17018589 17172411 17287894
MESH:D003110 Colonic Neoplasms Genistein 3.7017182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.6818802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.6816303861 16391804 18802399 18288408 18509181 14970324 16524972 17255274 15289873 17016601 17401013 18949393 17454858 17094418 15148649 20501625 18383874 18448328 17695437 17594712 16282729 16331619
MESH:D015179 Colorectal Neoplasms Paclitaxel 4.6818802399
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 4.6815531428
MESH:D003139 Common Cold Ascorbic Acid 5.2417323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 5.2515513904 15451039 11873399 11198716 10194807 19302082 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2520055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.259125849 10589399 9664655 9142499 14991402 17551590 9224671 9211117 8800419 16925845
MESH:D019465 Craniofacial Abnormalities triadimefon 5.2516875885 15834900
MESH:D003556 Cystitis Cyclophosphamide 4.7516413132 16651033 12388444 12161096 10498854 18710439 16614059 18433785 18372110 12913760 15276878 11948286 15643279 18483878 18093676 16989017 17010015 10700343 17979934 18295254
MESH:D007644 Darier Disease Fluorouracil 4.5616733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.5016140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.8810990075 11751995 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1518772604
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.8816506275
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.8816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.4111743745 16177239 19420014 11461765 2444490 18071297 17562736 19416960 19164858 11834606 10774834 16227642 14550746 15968718 19370779 16109766 11739529 14986274 12392966 16081117 15619225 19739265 12540782 14725611 18713872 16781746 19923254 12958197 12594235 19085960 12153990 17522070 16393943 11421492 16485898 11287661 12705907 10915739 11529661 10663392 17906064
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.4117416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.4111566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.4120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Doxorubicin 7.5618602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5611462148
MESH:D004421 Dystonia Phenobarbital 3.791851702
MESH:C538011 Eales disease Ascorbic Acid 5.249068938
MESH:D004487 Edema pirinixic acid 5.8712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1715322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1718230668
MESH:D004714 Endometrial Hyperplasia Genistein 4.3616402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.5917359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.5919148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 16.5911473722
MESH:D016889 Endometrial Neoplasms Tretinoin 16.5916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.829294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9318037988
MESH:D004802 Eosinophilia Cyclophosphamide 3.9911006010
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.883659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.643922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.356401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.037750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.793659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.9520426865
MESH:D004938 Esophageal Neoplasms Ethanol 9.9516704527
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.9516481741 15173087 17638652 16337965 16785472
MESH:D004938 Esophageal Neoplasms Paclitaxel 9.9516481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.289664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 11.9419224547
MESH:D005234 Fatty Liver Ethanol 11.9419236843 18620774 16409862
MESH:D005234 Fatty Liver pirinixic acid 11.9419236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0716946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3619069698
MESH:D005355 Fibrosis Cyclosporine 13.4212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.4220067830
MESH:D005355 Fibrosis Tretinoin 13.4217994277
MESH:D005756 Gastritis Acetaminophen 10.3616983495
MESH:D005756 Gastritis Ethanol 10.3615046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma Doxorubicin 11.0817150277
MESH:D005909 Glioblastoma Genistein 11.0816598420
MESH:D005909 Glioblastoma Tretinoin 11.0817312396
MESH:D005910 Glioma Fluorouracil 2.7816145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.2811389073
MESH:D005911 Gliosis Paraquat 4.9311124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.8116376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.1015692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.1015162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.1016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 10.5516080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.559664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.3314766674 17888722 16879835 18674790 17875725 16330681 18006777 16144979 16244372 16707910 16495754 12587719 16244371
MESH:D006333 Heart Failure Doxorubicin 6.5917481944
MESH:D006333 Heart Failure pirinixic acid 6.5920558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7015692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.0611918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.3014986274
MESH:D006529 Hepatomegaly Phenobarbital 24.7716109766
MESH:D006529 Hepatomegaly pirinixic acid 24.7719176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly systhane 24.7717178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 24.7715340226 16120746 12621046
MESH:D006529 Hepatomegaly triadimefon 24.7717178688 17178689
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.4016490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 7.0817606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 7.0815147373 18501091 17606976
MESH:D019584 Hot Flashes Estradiol 3.5217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.818697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 12.0416870215
MESH:D006930 Hyperalgesia Ethanol 12.0418783367
MESH:D006930 Hyperalgesia Tretinoin 12.0416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006973 Hypertension Cyclosporine 4.6610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6618670907 18850075
MESH:D007154 Immune System Diseases Cyclophosphamide 5.1016076520
MESH:D007248 Infertility, Male Cyclophosphamide 6.6616517039 7193160
MESH:D007248 Infertility, Male Paraquat 6.664850670
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7512200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 11.4616393666
MESH:D007333 Insulin Resistance Estradiol 11.4616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.4616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5417994277
MESH:D007569 Jaw Abnormalities Ethanol 22.9615513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 22.9616580747
MESH:D007569 Jaw Abnormalities Tretinoin 22.9615992940 17551590
MESH:D007569 Jaw Abnormalities triadimefon 22.9615992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Acetaminophen 13.3515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 13.358314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 13.3515699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 13.3515618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9516707910
MESH:D007680 Kidney Neoplasms Cyclosporine 11.3412371664
MESH:D007680 Kidney Neoplasms Estradiol 11.3415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.3416985049
MESH:D007859 Learning Disorders Ethanol 3.9915451040
MESH:D007938 Leukemia Cyclophosphamide 9.9310602166
MESH:D007938 Leukemia Genistein 9.9317468513 18980019
MESH:D007938 Leukemia Tretinoin 9.9317143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9316085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4018587576 17802794 17296974 17008537 18172266 17658394
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.9210373061
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4919285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0117361223 16788101 17107899 17649720 19075265 16331271 19642359 16935935 17294898 12679006 16823087 16140955 17339181 17368321 16891316 17506722 9834237 19029980 17712046 15748426 19035177 17301526 16766008 19225113 17217047
MESH:D007970 Leukopenia Cyclophosphamide 4.7410052129 11830472
MESH:D017880 Limb Deformities, Congenital Ethanol 7.7817676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.789224671
MESH:D008080 Liposarcoma Paclitaxel 4.6117353645
MESH:D008103 Liver Cirrhosis Ethanol 6.4315289165
MESH:D008103 Liver Cirrhosis Phenobarbital 6.4321047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8718295389
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 10.4716595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.4714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 10.4718166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.4717823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.4712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.4716248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 6.2712969438 16611625 19460945 11587558 19014921 12587719 19784758 16610002
MESH:D008107 Liver Diseases Phenobarbital 6.2719363144
MESH:D008107 Liver Diseases triadimefon 6.2719363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4317347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0416871587 17185352
MESH:D008113 Liver Neoplasms Fluorouracil 16.8515113037 16603448 17045692 18383874
MESH:D008113 Liver Neoplasms Methapyrilene 16.8515890375
MESH:D008113 Liver Neoplasms Phenobarbital 16.8519812893 8742319 15975961 19073162 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 16.8520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.8516984957
MESH:D008113 Liver Neoplasms triadimefon 16.8519028983
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 26.1218544905
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 26.1217085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 26.1218308698 1399818 6150874 2563599 17172636
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 26.121423854
MESH:D008114 Liver Neoplasms, Experimental systhane 26.1217178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.1212151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 26.1217178689
MESH:D008171 Lung Diseases Ascorbic Acid 3.8016863852
MESH:D008175 Lung Neoplasms Ascorbic Acid 4.6716401635
MESH:D008175 Lung Neoplasms Doxorubicin 4.676189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 4.6715246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6711884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5615086387
MESH:D008223 Lymphoma Cyclophosphamide 7.3412854902
MESH:D008223 Lymphoma Doxorubicin 7.3416098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.3816675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 13.6011911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 13.6017654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 13.6014749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.2015458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.2011807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.2014578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.2519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Doxorubicin 4.9816827129
MESH:D008545 Melanoma Paclitaxel 4.9812040289 16342250 12025231
MESH:D008545 Melanoma Tretinoin 4.9816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 10.0819513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.0816388313
MESH:D008569 Memory Disorders Ethanol 3.9715451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D008654 Mesothelioma Doxorubicin 2.9717638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D008708 Methemoglobinemia Phenacetin 4.744834387 1949026 3537620 16296465
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2915792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4616757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.5617415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.5314749477
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9517596541
MESH:D009203 Myocardial Infarction Doxorubicin 8.9319429709 15857846
MESH:D009203 Myocardial Infarction Genistein 8.9317141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.9319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.1716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.1717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.1716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2517484760
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.8318259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.8315867366
MESH:D009369 Neoplasms Cyclophosphamide 10.9618854779
MESH:D009369 Neoplasms Fluorouracil 10.9618239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 10.9617405874
MESH:D009369 Neoplasms Tretinoin 10.9616594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009401 Nephrosis Doxorubicin 4.5416636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.6619348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.6615640375 16889571
MESH:D009410 Nerve Degeneration Paraquat 8.0716893418
MESH:D009410 Nerve Degeneration Rotenone 8.0718619942 17356569 15790535
MESH:D009421 Nervous System Malformations bisphenol A 28.4016427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 28.4011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 28.4016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 28.4014600291
MESH:D009421 Nervous System Malformations Tretinoin 28.409125849
MESH:D009436 Neural Tube Defects Tretinoin 2.919142499
MESH:D009447 Neuroblastoma Cyclophosphamide 6.838761367 15176712 16115947
MESH:D009447 Neuroblastoma Doxorubicin 6.8315555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6918514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.668761367 12837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2916436463
MESH:D009503 Neutropenia Cyclophosphamide 4.118291058
MESH:D009765 Obesity Ascorbic Acid 4.5517217161
MESH:D009765 Obesity pirinixic acid 4.5520558911
MESH:D009845 Oligospermia Cyclophosphamide 4.4816517039
MESH:D010014 Osteolysis Paclitaxel 4.7515867366
MESH:D010018 Osteomalacia Phenobarbital 4.1317016548
MESH:D010024 Osteoporosis Genistein 3.1119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8716169203
MESH:D012516 Osteosarcoma Doxorubicin 3.9315930896
MESH:D010049 Ovarian Diseases bisphenol A 4.7611985600
MESH:D010051 Ovarian Neoplasms Estradiol 10.7219401270
MESH:D010051 Ovarian Neoplasms Genistein 10.7219005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 10.7211161223
MESH:D010051 Ovarian Neoplasms Tretinoin 10.7216936753
MESH:D010146 Pain Acetaminophen 10.2316870215
MESH:D010146 Pain Cyclophosphamide 10.2312161096 18093676
MESH:D010146 Pain Tretinoin 10.2316870215
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 15.4511332152
MESH:D010190 Pancreatic Neoplasms Ethanol 15.4512384795
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.4515113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 15.4516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.4515976015
MESH:D010300 Parkinson Disease Paraquat 8.3416510128 12911755 15451049 11445065 11124998 15824117 16140633 11181820
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 8.3416702228
MESH:D010300 Parkinson Disease Rotenone 8.3416412576 15451049 18619942 11445065 16140633 19232380 18191903 11535288 19114014
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.2116190885
MESH:D020734 Parkinsonian Disorders Rotenone 3.8815927086 18197244 15574749 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9317638057
MESH:D011014 Pneumonia Paraquat 4.2212504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.3312371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.332563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6821297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.7510548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7511118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.8720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.8720887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4116740699
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.4117136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.4116888761 15749863 18437689 16868541 15897917 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 2.4116740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.4118626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.4116925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.4117172428 16356831 16729912 17136230
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.4115721890
MESH:D011507 Proteinuria Tretinoin 3.3916636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.2612752131
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5610548101
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.1014606601
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.7116636934
MESH:D011658 Pulmonary Fibrosis Paraquat 5.7117997886 16324872
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8218722050 16160472 18286688 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 4.0017922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.7011700416
MESH:D012135 Respiratory Sounds Paraquat 3.8311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012162 Retinal Degeneration Paraquat 3.7016458197
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2516849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8916283617 16116481
MESH:D012509 Sarcoma Doxorubicin 3.7917710206 15675481 15625365 18313854 16767912 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5617846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.6116636934
MESH:D012640 Seizures Ethanol 5.659754883
MESH:D012640 Seizures Phenobarbital 5.6511442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.596407741
MESH:D012871 Skin Diseases Ascorbic Acid 3.1518709164
MESH:D012878 Skin Neoplasms Doxorubicin 12.6915692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.698532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.6916192470
MESH:D012878 Skin Neoplasms Tretinoin 12.6916467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3417203757 15625365 16767912
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.2816517039
MESH:D013274 Stomach Neoplasms Ethanol 4.5918456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.5917522103 17172411 18396642 19084572 15786421 18567086 16424979 17498489 19015929 16951190
MESH:D013274 Stomach Neoplasms Paclitaxel 4.5918396642 18506536
MESH:D013274 Stomach Neoplasms Tretinoin 4.5917261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 7.0218726076
MESH:D013276 Stomach Ulcer Ethanol 7.029211565 16755016 9562338 11906479 17189318 17918041
MESH:D020521 Stroke Ascorbic Acid 4.1116403987 16517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.7616045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.069754883
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.32978859
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.8312837982
MESH:D024801 Tauopathies Paclitaxel 4.5816930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 15.7616010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.761399818
MESH:D013964 Thyroid Neoplasms Tretinoin 15.7616026305 17045167
MESH:D013964 Thyroid Neoplasms triadimefon 15.7617178689
MESH:D013978 Tibial Fractures Estradiol 4.4519048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.1716280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.1716051514
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 8.1414692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.1417653716
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 8.1411144890
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.7916803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.7916129372
MESH:D014591 Uterine Diseases bisphenol A 4.7814652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.3816752155
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0017334414 17638931 17678736 16364871
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28653
    • No data
    Releated disease ID Related disease Name
    PA162372590Renal agenesis
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03684 - 2-Methyl-2,4-Pentanediol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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