AutismKB 2.0

Annotation Detail for GFRA2


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Basic Information Top
Gene Symbol:GFRA2 ( GDNFRB,NRTNR-ALPHA,NTNRA,RETL2,TRNR2 )
Gene Full Name: GDNF family receptor alpha 2
Band: 8p21.3
Quick LinksEntrez ID:2675; OMIM: 601956; Uniprot ID:GFRA2_HUMAN; ENSEMBL ID: ENSG00000168546; HGNC ID: 4244
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GFRA2 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of GFRA2 mRNAdecreases expression 17805973
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of GFRA2 mRNAincreases expression 17452286
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GFRA2 mRNAdecreases expression 15834898
15576828
17557909
D015025 Zearalenone Zearalenone results in decreased expression of GFRA2 mRNAdecreases expression 17557909
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of GFRA2 mRNAaffects cotreatment|increases expression 17183730
C029938 nickel sulfate nickel sulfate results in decreased expression of GFRA2 mRNAdecreases expression 16780908
D020849 Raloxifene Raloxifene results in increased expression of GFRA2 mRNAincreases expression 15576828
D014212 Tretinoin Tretinoin affects the expression of GFRA2 mRNAaffects expression 16211290
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of GFRA2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury nickel sulfate 4.4919131640 16100012 11954676 12718980
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.5817119214 16611668 11874814
MESH:D000419 Albuminuria Raloxifene 4.7917451421 17308373
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.5415885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.5416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Valproic Acid 1.9917157402 20603192 18775368 18940202 16609825 18558336 18177632 18316065 19232924 18396377 17688650 17507914 19460635 15238991 18985861
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.1517594078 20046352
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7816206674 16197459
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001930 Brain Injuries Raloxifene 4.6916580743
MESH:D001943 Breast Neoplasms Raloxifene 2.3217893378 15775269 15572757 17242785 15758505 17952589 16912660 16837676 17049068 17440819 17261762 17595753
MESH:D001943 Breast Neoplasms Tretinoin 2.3216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9915673190 3786805 16192424 10355542 16227642 16011737 15700767 16097048 15721981 16124888 18705752 16050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1018788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.101917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3316051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2317572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5615775269
MESH:D002386 Cataract Tretinoin 3.1917460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0016919318 11677210 17681005 15861022 16105132 17333356 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003072 Cognition Disorders Raloxifene 4.8315800139
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.7210589399 9664655 17551590 9125849 16925845 14991402 9142499 9224671 8800419 9211117
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7216575769 17688650 8888407
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3117474826
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.8811298694 16780908 16823706
MESH:D003928 Diabetic Nephropathies Raloxifene 4.0917308373 15920148 17451421
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.1010915739 7440962 6884620 4309450 21278145 15968718 7179309 9327722 7120509 16177239 3732212 17522070 19336974 2869522 15027814 16227642 15998439 19085960 3786805 11566570 6623471 10092053
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.101733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema Raloxifene 3.5115860553
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.7815845917
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D005124 Eye Abnormalities Tretinoin 3.7016938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2812795759 12631006 19224547 15959796 16239168 16045604 61145 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2815345470
MESH:D005234 Fatty Liver Raloxifene 20.2817473493
MESH:D005234 Fatty Liver Valproic Acid 20.2819224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 9.5318705752
MESH:D005355 Fibrosis Tretinoin 9.5317994277
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9814991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.6511110106
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006930 Hyperalgesia Tretinoin 3.3516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006973 Hypertension Raloxifene 2.9215787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0717551590 15992940
MESH:D007889 Leiomyoma Raloxifene 4.6816973256
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9719850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9716294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2616331271 19075265 17368321 16891316 17217047 17339181 16766008 16823087 15748426 17712046 17301526 9834237 19029980 19642359 16935935 17649720 16140955 17361223 19225113 17107899 12679006 19035177 17506722 16788101 17294898
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8916943688 21278145 11408273 17334410 11903743 16239168 16221502 17174718 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5418263696 17761835 16015684 18395914 14716833 18006644 15959796 15818738 14748882 12649538 18277467 14620537 18472332 12632514 15996030 15925388 16033810 17922224 17805973 16136751 15876570 16638106 18317297 12445418 16192424 12546737 18339082 15673190 20821823 15730626 12741479 17708605 17976157 17557913 16011737 14512876 17766677 15370692 15362042 12666154 17631135 17823541 12667390 14716496 18420326 18376398 18481824 17481882 17640975 18251166 17721639 18210741 11481614 16248980 15052691 18054572 18279442 15931870 12586293 17714472 16097048 17698563 18156304 18472094 12958196 17869086 14724832 12898905 16027843 12389079 18205269 13678700 15123356 15057751 15338365 10355542 17900296 15893842 16116963 15650968 17525996 18705752 18418968 18166357 17565644 18187930 18395095 17944888 18429990 12632512 12445421 18412020 12609069
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5416248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.5617285989 15830285 15720792 16246199 16964402
MESH:D008107 Liver Diseases Chlorpyrifos 4.5615991261
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.2719294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7112014681 15583823
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8215863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5616497877
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.7017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7017596541
MESH:D009232 Myxoma Raloxifene 5.8216343187
MESH:D009369 Neoplasms Tretinoin 2.4816946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects Tretinoin 7.669142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.6616359493 8888407
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2815081274
MESH:D010024 Osteoporosis Raloxifene 3.4917882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4115758505 15579764 17893378 17823083
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3916936753
MESH:D010146 Pain Tretinoin 3.0416870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5816220300 15731164 16536755
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D011693 Purpura Raloxifene 5.8215770314
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.8516611668 17119214 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.1617119214 16611668
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.4916283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.4919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8515475178 3137016 16876388 14763951 11738929 11044598 17978042 1511512
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.356418539
MESH:D012878 Skin Neoplasms Tretinoin 2.6816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Raloxifene 3.9616837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1517045167 16026305
MESH:D013978 Tibial Fractures Raloxifene 5.4719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8717572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D054556 Venous Thromboembolism Raloxifene 5.4716837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8216343187
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
REACT:18266 Axon guidance
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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