AutismKB 2.0

Annotation Detail for RPS6KC1


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Basic Information Top
Gene Symbol:RPS6KC1 ( RPK118,humS6PKh1 )
Gene Full Name: ribosomal protein S6 kinase, 52kDa, polypeptide 1
Band: 1q32.3
Quick LinksEntrez ID:26750; OMIM: NA; Uniprot ID:KS6C1_HUMAN; ENSEMBL ID: ENSG00000136643; HGNC ID: 10439
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00047PDGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RPS6KC1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RPS6KC1 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RPS6KC1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of RPS6KC1 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RPS6KC1 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of RPS6KC1 mRNAincreases expression 20106945
D012402 Rotenone Rotenone results in decreased expression of RPS6KC1 mRNAdecreases expression 19013527
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0816705839
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.376135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.3720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.3712371664
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.1121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1121346803 18551238
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5716530937
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.9712371664
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.827678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8220195826 21137059
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.722876786 2876784 6135515
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720064080 6695378 18816296 20135361 18569708 17053015 20869020 18520028 20464547
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.947678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 4.1215790535 17356569 18619942
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010300 Parkinson Disease Rotenone 3.0711445065 19232380 19114014 15451049 16412576 18619942 11535288 16140633 18191903
MESH:D020734 Parkinsonian Disorders Rotenone 4.3818197244 15574749 15795934 15927086
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9217292933
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4910029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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