AutismKB 2.0

Annotation Detail for GGT1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GGT1 ( CD224,D22S672,D22S732,GGT,GGT 1,GTG,MGC96892,MGC96904,MGC96963 )
Gene Full Name: gamma-glutamyltransferase 1
Band: 22q11.23
Quick LinksEntrez ID:2678; OMIM: 612346; Uniprot ID:GGT1_HUMAN; ENSEMBL ID: ENSG00000100031; HGNC ID: 4250
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-4041gamma-glutamyl cycle
Pathway IDPathway Name
hsa00480Glutathione metabolism
hsa00590Arachidonic acid metabolism
hsa00430Taurine and hypotaurine metabolism
hsa00450Selenoamino acid metabolism
hsa01100Metabolic pathways
hsa00460Cyanoamino acid metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1703Fatty liver
1724Vascular disease
1825Oligospermia
1848Embryoma
1856Obesity
1859Ovarian cancer
1871Hepatitis
1879Glucose intolerance
1904Diabetes mellitus
1969Azoospermia
1976Squamous cell cancer
2008Liver disease
2022Liver cancer
2051Leukemia
2053Colon cancer
Desease Name
protein quantitative trait loci
plasma levels of liver enzymes
METABOLIC
Desease Name
Plasma levels of liver enzymes
Protein quantitative trait loci
Desease Name
Glutathioninuria
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in decreased expression of GGT1 mRNAdecreases expression 19784758
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of GGT1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of GGT1 mRNAaffects expression 19784758
D000082 Acetaminophen Acetaminophen results in decreased expression of GGT1 mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of GGT1 mRNAincreases expression 19784758
C069744 acetaminophen cysteine [GGT1 protein results in increased metabolism of [acetaminophen cysteine co-treated with Glutathione]] which results in increased abundance of gamma-glutamylcysteinylacetominophenaffects cotreatment|increases abundance|increases metabolic processing 15629191
C069744 acetaminophen cysteine GGT1 protein affects the reaction [acetaminophen cysteine results in decreased abundance of Glutathione]affects reaction|decreases abundance 15629191
C006303 acivicin acivicin results in decreased activity of GGT1 proteindecreases activity 15629191
C006303 acivicin acivicin results in decreased activity of GGT1 proteindecreases activity 15629191
D000814 Aniline Compounds GGT1 protein affects the metabolism of Aniline Compounds analogaffects metabolic processing 6149445
C030610 argemone oil argemone oil results in increased expression of GGT1 proteinincreases expression 15981203
D001151 Arsenic GGT1 mRNA results in decreased susceptibility to Arsenicdecreases response to substance 17976673
C006632 arsenic trioxide arsenic trioxide results in increased activity of GGT1 proteinincreases activity 18801422
C006632 arsenic trioxide arsenic trioxide results in increased expression of GGT1 mRNAincreases expression 18801422
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GGT1 protein]decreases activity|decreases reaction 16298753
D001888 Boric Acids Boric Acids analog results in decreased activity of GGT1 proteindecreases activity 6149445
D002104 Cadmium Cadmium results in increased activity of GGT1 proteinincreases activity 17165624
D002104 Cadmium kutkin inhibits the reaction [Cadmium results in increased activity of GGT1 protein]decreases reaction|increases activity 17165624
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of GGT1 mRNAdecreases expression 19784758
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased activity of GGT1 proteinincreases activity 15700767
D002251 Carbon Tetrachloride Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein]decreases reaction|increases activity 15700767
C004659 chlorobenzilate chlorobenzilate results in increased activity of GGT1 proteinincreases activity 2387028
D020111 Chlorodiphenyl (54% Chlorine) Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GGT1 protein]decreases activity|decreases reaction 16298753
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased activity of GGT1 proteindecreases activity 15955608
17283232
16298753
D020111 Chlorodiphenyl (54% Chlorine) Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GGT1 protein]decreases activity|decreases reaction 16298753
C074702 chromium hexavalent ion chromium hexavalent ion results in decreased activity of GGT1 proteindecreases activity 15980013
D003474 Curcumin Curcumin results in increased expression of GGT1 mRNAincreases expression 18299980
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of GGT1 mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine affects the expression of GGT1 proteinaffects expression 11589784
D016572 Cyclosporine Sirolimus promotes the reaction [Cyclosporine affects the expression of GGT1 protein]affects expression|increases reaction 11589784
D003634 DDT DDT results in increased activity of GGT1 proteinincreases activity 2387028
C014347 decitabine decitabine results in increased expression of GGT1 mRNAincreases expression 19194470
D003980 Diazooxonorleucine Diazooxonorleucine results in decreased activity of GGT1 proteindecreases activity 6149445
D015946 Ethylene Dibromide Ethylene Dibromide results in increased activity of GGT1 proteinincreases activity 12628311
D015946 Ethylene Dibromide Phentolamine inhibits the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]decreases reaction|increases activity 12628311
D015946 Ethylene Dibromide Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]increases activity|increases reaction 12628311
D004010 Dicofol Dicofol results in increased activity of GGT1 proteinincreases activity 2387028
D004052 Diethylnitrosamine Diethylnitrosamine results in increased activity of GGT1 proteinincreases activity 15563447
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of GGT1 mRNAincreases expression 19638242
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of GGT1 proteinincreases expression 19126423
D004052 Diethylnitrosamine Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased activity of GGT1 protein]decreases reaction|increases activity 15563447
D004391 Dust Dust results in increased expression of GGT1 mRNAincreases expression 17805423
D004726 Endosulfan Endosulfan results in increased activity of GGT1 proteinincreases activity 8588293
C031365 epomediol [Ethinyl Estradiol co-treated with epomediol] results in increased activity of GGT1 proteinaffects cotreatment|increases activity 12071332
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GGT1 mRNAaffects expression 14976129
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GGT1 mRNAincreases expression 14976129
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GGT1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with epomediol] results in increased activity of GGT1 proteinaffects cotreatment|increases activity 12071332
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased activity of GGT1 proteinincreases activity 12071332
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of GGT1 geneincreases mutagenesis 16724327
C033789 fenarimol fenarimol results in increased activity of GGT1 proteinincreases activity 2387028
C017690 fenvalerate fenvalerate affects the expression of GGT1affects expression 12479040
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of GGT1 mRNAincreases expression 17187413
D005492 Folic Acid Folic Acid affects the activity of GGT1 proteinaffects activity 16967759
C497432 gamma-glutamylcysteinylacetominophen [GGT1 protein results in increased metabolism of [acetaminophen cysteine co-treated with Glutathione]] which results in increased abundance of gamma-glutamylcysteinylacetominophenaffects cotreatment|increases abundance|increases metabolic processing 15629191
D005978 Glutathione [GGT1 protein results in increased metabolism of [acetaminophen cysteine co-treated with Glutathione]] which results in increased abundance of gamma-glutamylcysteinylacetominophenaffects cotreatment|increases abundance|increases metabolic processing 15629191
D005978 Glutathione GGT1 protein affects the reaction [acetaminophen cysteine results in decreased abundance of Glutathione]affects reaction|decreases abundance 15629191
C051890 irinotecan irinotecan analog results in decreased expression of GGT1 mRNAdecreases expression 18927307
C038267 isopropyl 4,4'-dibromobenzilate isopropyl 4,4'-dibromobenzilate results in increased activity of GGT1 proteinincreases activity 2387028
C057463 kutkin kutkin inhibits the reaction [Cadmium results in increased activity of GGT1 protein]decreases reaction|increases activity 17165624
D001556 Lindane Lindane results in increased activity of GGT1 proteinincreases activity 11349524
D001556 Lindane Plant Extracts inhibits the reaction [Lindane results in increased activity of GGT1 protein]decreases reaction|increases activity 11349524
D008550 Melatonin Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein]decreases reaction|increases activity 15700767
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in decreased expression of GGT1 mRNAdecreases expression 18187559
D009578 Nitrobenzenes Nitrobenzenes analog results in decreased expression of GGT1 mRNAdecreases expression 19784758
C025589 ochratoxin A ochratoxin A results in decreased expression of GGT1 mRNAdecreases expression 16251485
D026023 Permethrin Permethrin results in increased activity of GGT1 proteinincreases activity 2902710
D010634 Phenobarbital Phenobarbital results in increased expression of GGT1 mRNAincreases expression 2563599
D010646 Phentolamine Phentolamine inhibits the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]decreases reaction|increases activity 12628311
D010656 Phenylephrine Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]increases activity|increases reaction 12628311
D010936 Plant Extracts Plant Extracts inhibits the reaction [Lindane results in increased activity of GGT1 protein]decreases reaction|increases activity 11349524
D010936 Plant Extracts Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased activity of GGT1 protein]decreases reaction|increases activity 15563447
D011411 Propanil Propanil affects the activity of GGT1 proteinaffects activity 18973941
C005705 sanguinarine sanguinarine results in increased expression of GGT1 proteinincreases expression 15981203
C515055 S-(dimethylarsino)-glutathione S-(dimethylarsino)-glutathione results in increased expression of GGT1 mRNAincreases expression 19417148
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of GGT1 mRNAaffects cotreatment|increases expression 19244175
D020123 Sirolimus Sirolimus promotes the reaction [Cyclosporine affects the expression of GGT1 protein]affects expression|increases reaction 11589784
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GGT1 mRNAaffects cotreatment|increases expression 17942748
D013853 Thioacetamide Thioacetamide results in decreased expression of GGT1 mRNAdecreases expression 19784758
D014212 Tretinoin Tretinoin results in increased expression of GGT1 mRNAincreases expression 16788091
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of GGT1 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GGT1 protein]decreases activity|decreases reaction 16298753
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 10.817525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.816195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.8115322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3317505938
MESH:D058186 Acute Kidney Injury Folic Acid 3.8017003819 16316344 16595132
MESH:D000230 Adenocarcinoma arsenic trioxide 3.6519825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.6514692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 17.0910737359
MESH:D000236 Adenoma Diethylnitrosamine 17.096695378 10737359
MESH:D000236 Adenoma Ethylnitrosourea 17.096695378
MESH:D000236 Adenoma Folic Acid 17.0916963246
MESH:D000236 Adenoma Melatonin 17.0917195641
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.396705139
MESH:D018248 Adenoma, Liver Cell DDT 20.0412597452
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.0419052882 18056438 17620307 17162532 19061943 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.0417620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.0416835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.6017306315
MESH:D000382 Agricultural Workers' Diseases DDT 11.3912584743 16487989
MESH:D000382 Agricultural Workers' Diseases Dicofol 11.3912584743
MESH:D000382 Agricultural Workers' Diseases Lindane 11.3912661182
MESH:D019973 Alcohol-Related Disorders Curcumin 4.4717887948
MESH:D000505 Alopecia Tretinoin 3.1315955085
MESH:D000544 Alzheimer Disease Curcumin 5.8115590663
MESH:D000544 Alzheimer Disease Folic Acid 5.8117116317
MESH:D000544 Alzheimer Disease Plant Extracts 5.8116962711
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4311748828
MESH:D000799 Angioedema Acetaminophen 3.2310982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.5917460149
MESH:D020261 Arsenic Poisoning Arsenic 2.6716835338 16251483 18414634 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.0315885639
MESH:D001169 Arthritis, Experimental Plant Extracts 10.0314686799
MESH:D001169 Arthritis, Experimental Tretinoin 10.0316412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.1216807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1216292516
MESH:D001249 Asthma Tretinoin 2.1416456186
MESH:D050197 Atherosclerosis Arsenic 8.9212928151 19371607
MESH:D050197 Atherosclerosis Cadmium 8.9215687053
MESH:D050197 Atherosclerosis Curcumin 8.9218704882
MESH:D001321 Autistic Disorder Acetaminophen 3.1618445737
MESH:D001321 Autistic Disorder Folic Acid 3.1621388746
MESH:D001321 Autistic Disorder Glutathione 3.1616917939 19267885 19056591 18929414
MESH:D001321 Autistic Disorder Melatonin 3.1616897403 16919138
MESH:D001321 Autistic Disorder Sirolimus 3.1621115397
MESH:D001327 Autoimmune Diseases Curcumin 3.9119761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8316935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 17.5816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 17.5812125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 17.5819483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 17.5816197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3615746008
MESH:D001919 Bradycardia Phenylephrine 3.9515306635
MESH:D001927 Brain Diseases Ethylnitrosourea 4.3514991843
MESH:D002545 Brain Ischemia Curcumin 8.5016770732
MESH:D002545 Brain Ischemia Plant Extracts 8.5016041641
MESH:D001932 Brain Neoplasms Curcumin 7.4017596214
MESH:D001932 Brain Neoplasms Ethylnitrosourea 7.4016651633 15144691 16357521 18412241 16436596
MESH:D001943 Breast Neoplasms Ascorbic Acid 7.2216443354
MESH:D001943 Breast Neoplasms Curcumin 7.2218593918 18462866 19250217 16243823
MESH:D001943 Breast Neoplasms DDT 7.2216792888 12709520
MESH:D001943 Breast Neoplasms decitabine 7.2218320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.2217474063
MESH:D001943 Breast Neoplasms Ethylene Dibromide 7.2211921183
MESH:D001943 Breast Neoplasms Folic Acid 7.2216777985
MESH:D001943 Breast Neoplasms Lindane 7.2214688026
MESH:D001943 Breast Neoplasms ochratoxin A 7.2211921183
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.2220435547
MESH:D001943 Breast Neoplasms Tretinoin 7.2216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9916813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.7711589617
MESH:D002057 Burns, Chemical Plant Extracts 4.729625245
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 13.6015721981 16192424 15700767 10355542 15673190 16011737 16227642 18705752 16124888 16097048 3786805 16050911
MESH:D002252 Carbon Tetrachloride Poisoning Melatonin 13.6015700767
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 13.6016050911
MESH:D002277 Carcinoma Curcumin 6.6818593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.6816835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.2215504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5516168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 25.8510737359 3581430 6705139 3084413 17761372
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 25.853084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 25.8517306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 25.8515553829 16217749 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 25.8518788625
MESH:D006528 Carcinoma, Hepatocellular DDT 25.8512597452
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 25.8516779866 18393292 20084675 20514400 18978308 18691550 19519916 17055752 19822196 19701751 19107877 19052882 17162532 20101231 18971187 16935385 16807293 18506893 10737359 20432363 21159647 20727157 18785209 17761372 18665156 16681979 19418558 16878318 16830150 16502159 16540662 19208518 20007298 18788625 19383236 19919837 16698587 3084413 20512989 18056438 19394651 18494052 19335982 20214788 3581430 16328049 11831363 16569478 20935162 18210153 17138121 10672840 17173139 20524982 17428255 16288022 19171122 19539802 17978847
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 25.8517173139 20935162 1701930 6705139 20007298
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 25.8518834353
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 25.8519335982
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 25.8517997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 25.851917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7418414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.2619014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.5912490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 15.2315504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Curcumin 15.2318462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 15.2319215824
MESH:D002294 Carcinoma, Squamous Cell Glutathione 15.2317015178
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 15.2319435901
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 15.2316096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.5518640142
MESH:D006332 Cardiomegaly Phenylephrine 9.4217124262 15728586 16170337 17287366 11754973 11179087
MESH:D006332 Cardiomegaly Plant Extracts 9.4217645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.4216120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 6.3015738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases Folic Acid 6.3016755160
MESH:D002340 Carotid Artery Diseases Arsenic 3.8016973168 18022660
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 10.1614694615
MESH:D002386 Cataract Acetaminophen 10.1610977129
MESH:D002386 Cataract Tretinoin 10.1617460283
MESH:D002471 Cell Transformation, Neoplastic Cadmium 12.5617332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.5612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.5617174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 12.5616003739
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.674080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.3717160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9916129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.1719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.1716835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 13.1718291259
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.5912912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 15.687624871 18164287 18590720 15500046 16629650 15913567 12927374 19486331
MESH:D002779 Cholestasis acivicin 15.687624871
MESH:D002779 Cholestasis Cyclosporine 15.6819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 15.6816919318 17110522 16105132 17333356 17681005 11677210 15861022
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.2419407337 10220858
MESH:D002822 Choriocarcinoma Tretinoin 4.5516461808
MESH:D002971 Cleft Lip Folic Acid 3.6421254359
MESH:D002972 Cleft Palate Folic Acid 8.208946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.2016354765 8697196 12621046 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 8.209407595
MESH:D003092 Colitis Curcumin 12.6718200517 16782535 16804969
MESH:D003092 Colitis Selenium 12.6717936198
MESH:D003092 Colitis Tretinoin 12.6717035595
MESH:D003103 Coloboma Curcumin 4.0118809619
MESH:D003110 Colonic Neoplasms Curcumin 5.0719359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 5.0717616700
MESH:D003110 Colonic Neoplasms irinotecan 5.0717725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.2020501625
MESH:D015179 Colorectal Neoplasms decitabine 4.2018981723
MESH:D015179 Colorectal Neoplasms Folic Acid 4.2016985020 17245555 17116713 17087956 16963246
MESH:D015179 Colorectal Neoplasms irinotecan 4.2018259882 15273666 17159606 16303861 16391804 18509181 17454858
MESH:D003139 Common Cold Ascorbic Acid 4.8617323712
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 12.7215095906
MESH:D000013 Congenital Abnormalities DDT 12.7215095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 12.7214669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.3118497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 8.2410525206
MESH:D019465 Craniofacial Abnormalities ochratoxin A 8.2420036863
MESH:D019465 Craniofacial Abnormalities Permethrin 8.2419861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.2420055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 8.249224671 10589399 9211117 17551590 8800419 16925845 9664655 9125849 9142499 14991402
MESH:D019465 Craniofacial Abnormalities Vitamin E 8.2419769572
MESH:D003490 Cyanosis Endosulfan 10.367900959
MESH:D003490 Cyanosis Propanil 10.364714336
MESH:D003550 Cystic Fibrosis Glutathione 3.9719747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.5415213294
MESH:D003877 Dermatitis, Contact Permethrin 4.4414617103
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 11.5916506275
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 11.5918403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 11.5920387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 11.5916886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 11.5917107852
MESH:D003928 Diabetic Nephropathies Curcumin 7.7118204486
MESH:D003928 Diabetic Nephropathies Plant Extracts 7.7119706694
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 28.1517522070 20133375 7624871 18289764
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 28.1521346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 28.1512540782 18071297 15619225 12958197 19923254 11461765 19370779 16781746 17562736 14986274 16485898 10915739 10774834 16081117 11529661 19739265 11743745 11287661 14550746 16227642 16393943 16109766 10663392 19085960 12392966 17906064 12705907 11834606 18713872 16177239 11739529 14725611 12153990 19416960 2444490 19420014 17522070 12594235 19164858 15968718 11421492
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 28.1519336974 21278145 15998439 16227642 3786805 9327722 7120509 16177239 7179309 15968718 10092053 2869522 15027814 10915739 11566570 4309450 3732212 19085960 6623471 17522070 6884620 7440962
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 28.1517851650
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 28.1517654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 28.1519107877
MESH:D056486 Drug-Induced Liver Injury Ethylene Dibromide 28.152862719
MESH:D056486 Drug-Induced Liver Injury Selenium 28.1515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 28.1520420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 28.1512963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.4919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3111462148
MESH:D004381 Duodenal Ulcer Curcumin 3.4817351913
MESH:D004417 Dyspnea DDT 9.0216487989
MESH:D004417 Dyspnea Endosulfan 9.027900959 3388749
MESH:D004421 Dystonia Phenobarbital 3.451851702
MESH:C538011 Eales disease Ascorbic Acid 11.039068938
MESH:C538011 Eales disease Vitamin E 11.039068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.3718357618
MESH:D004487 Edema Plant Extracts 5.2812787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.2812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.9115322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 9.9118230668
MESH:D004646 Emphysema Endosulfan 5.947900959
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.6212538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5019294695
MESH:D016889 Endometrial Neoplasms Folic Acid 6.4117301261
MESH:D016889 Endometrial Neoplasms Tretinoin 6.4116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.509294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.0715268973
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.523659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.2611558140 3922381
MESH:D004827 Epilepsy Phenobarbital 5.8220417680
MESH:D004827 Epilepsy Plant Extracts 5.8219439326 19700373
MESH:D004832 Epilepsy, Absence Phenobarbital 3.046401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.423659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5016302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.1412903497
MESH:D017889 Exfoliation Syndrome Folic Acid 4.8916504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.3011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.3016938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 5.1116456712
MESH:D005234 Fatty Liver arsenic trioxide 28.7515073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.7512631006 15959796 12795759 19224547 61145 16239168 16045604 17595544
MESH:D005234 Fatty Liver Curcumin 28.7519297423
MESH:D005234 Fatty Liver Cyclosporine 28.7519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 28.7520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.7515345470
MESH:D005234 Fatty Liver Plant Extracts 28.7515975614
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 21.5618705752
MESH:D005355 Fibrosis Curcumin 21.5618705752
MESH:D005355 Fibrosis Cyclosporine 21.5612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 21.5620067830
MESH:D005355 Fibrosis Tretinoin 21.5617994277
MESH:D005534 Foot Diseases Arsenic 4.956392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.6916904648
MESH:D005756 Gastritis Acetaminophen 9.2416983495
MESH:D005756 Gastritis Folic Acid 9.2417171786
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1118462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.628708960
MESH:D005901 Glaucoma Folic Acid 4.5216504073
MESH:D005909 Glioblastoma Curcumin 9.6317596214
MESH:D005909 Glioblastoma Ethylnitrosourea 9.6316436596
MESH:D005909 Glioblastoma Tretinoin 9.6317312396
MESH:D005910 Glioma Ethylnitrosourea 3.2216651633 16357521 18412241
MESH:C536836 Glutathionuria marker/mechanism
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9810696789
MESH:D006258 Head and Neck Neoplasms Curcumin 15.0318829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 15.0319215824
MESH:D006258 Head and Neck Neoplasms Sirolimus 15.0319435901
MESH:D006258 Head and Neck Neoplasms Tretinoin 15.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5516084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 17.3616080930
MESH:D006330 Heart Defects, Congenital Folic Acid 17.3616524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 17.3611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 17.3614991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 17.3616080930
MESH:D006333 Heart Failure Plant Extracts 6.1318097624
MESH:D006333 Heart Failure Selenium 6.1317162251
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.706705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 3.876705139
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8215720958
MESH:D006470 Hemorrhage Endosulfan 8.657900959
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 8.6511000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.0315929193 18665440 17276928
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 17.8518590720
MESH:D006505 Hepatitis Carbon Tetrachloride 17.8519110552 19900420
MESH:D006505 Hepatitis DDT 17.8516487989
MESH:D006505 Hepatitis Thioacetamide 17.8516456712
MESH:D006529 Hepatomegaly chlorobenzilate 37.302387028
MESH:D006529 Hepatomegaly DDT 37.302387028
MESH:D006529 Hepatomegaly Dicofol 37.302387028
MESH:D006529 Hepatomegaly fenarimol 37.302387028
MESH:D006529 Hepatomegaly fenvalerate 37.3015602828
MESH:D006529 Hepatomegaly isopropyl 4,4'-dibromobenzilate 37.302387028
MESH:D006529 Hepatomegaly Phenobarbital 37.3016109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 37.3016120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.4517701891
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 5.2916490937 16863852
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.2916490937 16863852
MESH:D006561 Herpes Simplex Plant Extracts 4.0310715843
MESH:D015658 HIV Infections Plant Extracts 3.3412878215
MESH:D006679 HIV Seropositivity Folic Acid 4.8917209195
MESH:D019584 Hot Flashes Plant Extracts 8.3914716179 16566672 17454163
MESH:D019584 Hot Flashes Vitamin E 8.3914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.438697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.0316870215
MESH:D006930 Hyperalgesia Tretinoin 6.0316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9316899240
MESH:D006937 Hypercholesterolemia Curcumin 3.5218704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9816778211
MESH:D020138 Hyperhomocysteinemia Folic Acid 8.0516865747 16395265 16397167 16755160 16433478
MESH:D020138 Hyperhomocysteinemia Plant Extracts 8.0516484555
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 3.9317050553
MESH:D006949 Hyperlipidemias Plant Extracts 3.9215268973 15975614
MESH:D006973 Hypertension Arsenic 10.159931084 11953799 16076760
MESH:D006973 Hypertension Cyclosporine 10.1510903974
MESH:D006973 Hypertension Phenylephrine 10.158949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.1518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5015338365
MESH:D006984 Hypertrophy Phenylephrine 9.2218502941 12791704
MESH:D006984 Hypertrophy Sirolimus 9.2219211884
MESH:D006987 Hypesthesia Arsenic 4.9516093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2216945680 16569931
MESH:D007247 Infertility, Female Dicofol 8.8010631594 11762692
MESH:D007247 Infertility, Female Ethinyl Estradiol 8.8012013081
MESH:D007248 Infertility, Male DDT 12.7217192596 17157474
MESH:D007248 Infertility, Male decitabine 12.7217581917
MESH:D007248 Infertility, Male Endosulfan 12.728588293 9432128
MESH:D007248 Infertility, Male Ethinyl Estradiol 12.7217937319
MESH:D007249 Inflammation Curcumin 9.1718403477 17151092 16956363
MESH:D007249 Inflammation Diethylnitrosamine 9.1718785209
MESH:D007249 Inflammation Plant Extracts 9.1712787963 16366677 19332304 15997105
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.1712200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9318596194 18200517
MESH:D007251 Influenza, Human Selenium 8.9316624496
MESH:D007251 Influenza, Human Vitamin E 8.9316624496
MESH:D007299 Insect Bites and Stings Permethrin 5.2112971516 15189238 12749493
MESH:D007410 Intestinal Diseases Tretinoin 3.1817994277
MESH:D007414 Intestinal Neoplasms Curcumin 8.3710783313
MESH:D007414 Intestinal Neoplasms Plant Extracts 8.3712584176 12351151 12628509
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.1416580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.1415992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8315604871
MESH:D007642 Keratosis Arsenic 4.3912749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 23.1215629191 12587719
MESH:D007674 Kidney Diseases acetaminophen cysteine 23.1215629191
MESH:D007674 Kidney Diseases Cadmium 23.1216962696 16322080 16226777
MESH:D007674 Kidney Diseases Cyclosporine 23.128314463 10903974 18776723
MESH:D007674 Kidney Diseases Ethylene Dibromide 23.1212628311
MESH:D007674 Kidney Diseases ochratoxin A 23.1211409539
MESH:D007674 Kidney Diseases Vitamin E 23.1212488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.3516518626
MESH:D007680 Kidney Neoplasms Cyclosporine 9.8512371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 9.8517379185
MESH:D007680 Kidney Neoplasms ochratoxin A 9.8516251485
MESH:D007859 Learning Disorders DDT 8.517589230
MESH:D007859 Learning Disorders Endosulfan 8.518157075
MESH:D007889 Leiomyoma Curcumin 4.0218555241
MESH:D007896 Leishmaniasis fenarimol 4.9218372651
MESH:D007938 Leukemia arsenic trioxide 16.1715070760
MESH:D007938 Leukemia Curcumin 16.1718462866
MESH:D007938 Leukemia decitabine 16.1719235587 18980019
MESH:D007938 Leukemia Permethrin 16.1712937054
MESH:D007938 Leukemia Tretinoin 16.1717143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 7.9717077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 7.9716106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.7116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.9714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 12.8819077051
MESH:D007951 Leukemia, Myeloid decitabine 12.8817236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 12.8819285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.2716467208 17050201 16968895 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.2718460780 18704418 17679729 18206229 19010910 19387464
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.2717596541 16294345 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8518055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 10.3717339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 10.3717107899 16331271 19642359 15336539 17649720 19225113 15213294 12018890 16891316 16330433 17712046 19075265 12712474 17217047 11468182 16966277 19035177 15748426 16112521 17869043 16823087 11161223 9834237 15622746 12679006
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 10.3717361223 12679006 17339181 17506722 19075265 16766008 17107899 16891316 16788101 19225113 16823087 16331271 17294898 16935935 9834237 17649720 19035177 17301526 17712046 15748426 19642359 17217047 17368321 16140955 19029980
MESH:D015458 Leukemia, T-Cell arsenic trioxide 9.8116882451
MESH:D015458 Leukemia, T-Cell Curcumin 9.8116106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.869224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 12.8111903743 17174718 11408273 21278145 16943688 17157831 16239168 16221502 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 12.8120032147 19638242 18522880 18407596 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 12.8121047994
MESH:D008103 Liver Cirrhosis Plant Extracts 12.8117157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 13.5614620537 17481882 18376398 16136751 15673190 18263696 12389079 15893842 17698563 16011737 18006644 15650968 18054572 14748882 12649538 15052691 15925388 18472332 17922224 18472094 18279442 17869086 12898905 15959796 15931870 17976157 12632514 12958196 15338365 15996030 14716496 18205269 16248980 12445421 12666154 15057751 17708605 18705752 14512876 16116963 18395914 15362042 17761835 17631135 17805973 12632512 16638106 16192424 17721639 14716833 18277467 17944888 16015684 18317297 10355542 18187930 15818738 18339082 17557913 20821823 18412020 17766677 17823541 12667390 18251166 11481614 17714472 15123356 18210741 17640975 15730626 18156304 12445418 18166357 15370692 18429990 12546737 18481824 18395095 16033810 12609069 12741479 16027843 18418968 13678700 17525996 14724832 17900296 12586293 16097048 18420326 15876570 17565644
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 13.5618006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Melatonin 13.5615925388 15298665 16703270
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 13.5615479170
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 13.5617050028
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 13.5612878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 13.5615334695 17355460 17127702 11172339 16098781 15316131 18263696 16126171 15474484 18295389 15288473 18458672 11682029 15078482 12175628 15095483 12891558 15288472 12679928 16248980 16097051 15158331 16489207 16343077 15362042 15716488 18606216 17292413 14739098 18380797 18416461 18031379 17050028 10677585 11481614 17629604 12557150 18032466 18615449 16511523 15075984 15465738 12531686 12085344 18395095
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 13.5616248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 13.5616169303
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 33.5717184895
MESH:D008107 Liver Diseases Acetaminophen 33.5712587719 12969438 19460945 19784758 11587558 19014921 16610002 16611625
MESH:D008107 Liver Diseases Arsenic 33.5711134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 33.5716246199 17285989 16964402 15720792 15830285
MESH:D008107 Liver Diseases Curcumin 33.5716956363
MESH:D008107 Liver Diseases DDT 33.5715729006
MESH:D008107 Liver Diseases Diethylnitrosamine 33.5717034775
MESH:D008107 Liver Diseases Folic Acid 33.5716877991
MESH:D008107 Liver Diseases Lindane 33.571715830
MESH:D008107 Liver Diseases Phenobarbital 33.5719363144
MESH:D008107 Liver Diseases Plant Extracts 33.5717034775
MESH:D008107 Liver Diseases Thioacetamide 33.5718374380 15158337 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 3.5815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 13.2216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 13.2216899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 13.2212479984 17276928 15313186 15633222
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 24.7418001218 16273603 10672840 11376686 10737359 14678523
MESH:D008113 Liver Neoplasms Arsenic 24.7416368122
MESH:D008113 Liver Neoplasms arsenic trioxide 24.7414682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.7419294768
MESH:D008113 Liver Neoplasms DDT 24.7411948501 15975961
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.7419638242 20583210 18977376 19073162 20101389 2862719 18648771 10737359 15175105 20492335 18644402 20405173 19812893 19427195 19294768 20434301 19426721 21167192 15885732 18978307 21278145 21071580 20452335 19642983 19499222 19090486 18754104 19833225 19254457 21047994 12771043 19255062 20137499 20118626 19690152 19996281 19256749 2422723 12112319 16942905 9163691 20501860 19850985 19551842
MESH:D008113 Liver Neoplasms Phenobarbital 24.7419482888 8742319 15975961 21047994 19812893 19073162
MESH:D008113 Liver Neoplasms Plant Extracts 24.7419168119
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.7416984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 22.166150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 22.1620377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 22.1618544905
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.1615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.1616267830 9362446 19009564 16842330 19539802 21159647 18775883 17854601 18079962 18308698 19004024 17174075 18544905 3124819 18164116 19126423 17942915 18093689 18253720 2563599 19519916 18282651
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 22.1617172636 1399818 18308698 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.1612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.8915213294
MESH:D008171 Lung Diseases Ascorbic Acid 10.1816863852
MESH:D008171 Lung Diseases chromium hexavalent ion 10.1816775837
MESH:D008171 Lung Diseases Vitamin E 10.1816863852
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 20.4611376686
MESH:D008175 Lung Neoplasms Arsenic 20.4617306315 17976673 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 20.4611798837 19825857
MESH:D008175 Lung Neoplasms Ascorbic Acid 20.4616401635
MESH:D008175 Lung Neoplasms chromium hexavalent ion 20.4616570259 16876463
MESH:D008175 Lung Neoplasms Curcumin 20.4619359593 18462866 16243823
MESH:D008175 Lung Neoplasms Diethylnitrosamine 20.4621163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Ethylnitrosourea 20.466695378 16271038 17703301 16019985
MESH:D008175 Lung Neoplasms Melatonin 20.4617195641
MESH:D008175 Lung Neoplasms Plant Extracts 20.4620869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 20.4611884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 20.4611062179
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 5.3417718048
MESH:D008180 Lupus Erythematosus, Systemic Melatonin 5.3416373423
MESH:D008223 Lymphoma Curcumin 10.1418462866
MESH:D008223 Lymphoma decitabine 10.1419470736
MESH:D008223 Lymphoma Ethylnitrosourea 10.1415790496
MESH:D016399 Lymphoma, T-Cell Curcumin 9.7916173963
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 9.7915375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylene Dibromide 11.1311921183
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 11.1310767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 11.1311921183
MESH:D008325 Mammary Neoplasms, Experimental Selenium 11.1315318939
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.0916832597
MESH:D008527 Medulloblastoma Tretinoin 2.5117453147
MESH:D008545 Melanoma Curcumin 6.1918462866 17885582
MESH:D008545 Melanoma decitabine 6.1917785578 16505122
MESH:D008545 Melanoma Sirolimus 6.1919282848
MESH:D008545 Melanoma Tretinoin 6.1916752155
MESH:D008546 Melanoma, Experimental Acetaminophen 2.9819513568
MESH:D008569 Memory Disorders Curcumin 3.5917263510
MESH:D008579 Meningioma Ethylnitrosourea 5.3717943659
MESH:D008591 Meningomyelocele Tretinoin 3.8416940565
MESH:D008654 Mesothelioma Selenium 2.5215107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.1716801185
MESH:D008708 Methemoglobinemia Propanil 5.202237922 4714336 2315934
MESH:D008850 Microphthalmos ochratoxin A 5.2220036863
MESH:D009062 Mouth Neoplasms Sirolimus 4.2419435901
MESH:D052016 Mucositis irinotecan 4.4117159606
MESH:D009101 Multiple Myeloma arsenic trioxide 13.7319417148 15949261 11468182 19549372 14977855
MESH:D009101 Multiple Myeloma Curcumin 13.7319372569
MESH:D009101 Multiple Myeloma decitabine 13.7318172295
MESH:D009101 Multiple Myeloma S-(dimethylarsino)-glutathione 13.7319417148
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.3217962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.0618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 10.1716105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 10.1719010910 18608210 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 10.1717596541
MESH:D017202 Myocardial Ischemia Arsenic 7.3915371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.3912213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.8717484760
MESH:D009336 Necrosis Melatonin 4.8712195237
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 8.4316624393
MESH:D009361 Neoplasm Invasiveness Curcumin 8.4318495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.039029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 5.0318259882
MESH:D009369 Neoplasms DDT 12.268820588
MESH:D009369 Neoplasms decitabine 12.2619116145 17925555 19470736
MESH:D009369 Neoplasms fenvalerate 12.262895627
MESH:D009369 Neoplasms Lindane 12.2616818664 12807735
MESH:D009369 Neoplasms Tretinoin 12.2616946489 16594593
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 3.8216707424
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 3.9212497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.7718481113 19348381
MESH:D009422 Nervous System Diseases Dicofol 5.171856875
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.6214600291
MESH:D009421 Nervous System Malformations Tretinoin 7.629125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.0218462866
MESH:D009436 Neural Tube Defects Arsenic 18.4216620997
MESH:D009436 Neural Tube Defects arsenic trioxide 18.4210525206
MESH:D009436 Neural Tube Defects Folic Acid 18.4217438019
MESH:D009436 Neural Tube Defects ochratoxin A 18.4220036863
MESH:D009436 Neural Tube Defects Tretinoin 18.429142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 4.8116651423 16003739 17160924
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.6017168769
MESH:D009447 Neuroblastoma irinotecan 3.148761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.5418514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.5420387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.138761367
MESH:D020078 Neurogenic Inflammation Arsenic 3.8217056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5020387270
MESH:D009503 Neutropenia Folic Acid 3.9616322990
MESH:D009669 Nose Neoplasms chromium hexavalent ion 8.3416876463
MESH:D009669 Nose Neoplasms Ethylene Dibromide 8.349385384
MESH:D009765 Obesity Ascorbic Acid 6.6017217161
MESH:D009765 Obesity Curcumin 6.6019297423
MESH:D009765 Obesity Plant Extracts 6.6020132043 19056576
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 3.5814694615
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.3717160924
MESH:D010018 Osteomalacia Phenobarbital 3.7617016548
MESH:D010024 Osteoporosis Curcumin 3.0818719352
MESH:D010051 Ovarian Neoplasms Arsenic 12.5017306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 12.5012452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Curcumin 12.5019020741 18462866
MESH:D010051 Ovarian Neoplasms decitabine 12.5019331143 19259094
MESH:D010051 Ovarian Neoplasms Tretinoin 12.5016936753
MESH:D010146 Pain Acetaminophen 4.9816870215
MESH:D010146 Pain Tretinoin 4.9816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 17.1315580305
MESH:D010190 Pancreatic Neoplasms Curcumin 17.1319401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms decitabine 17.1319294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 17.1316540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 17.1316965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 17.1315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1311578682
MESH:D010212 Papilloma Plant Extracts 3.9116517061 15173996
MESH:D010235 Paraganglioma arsenic trioxide 3.6119927285
MESH:D010243 Paralysis fenvalerate 5.408952708
MESH:D010300 Parkinson Disease Sirolimus 3.4919682553
MESH:D020734 Parkinsonian Disorders Melatonin 4.5115574749
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 11.7520133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 11.7512520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.6116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 11.0916905509 6392382 15371236
MESH:D016491 Peripheral Vascular Diseases Cadmium 11.0915687053
MESH:D010538 Peritonitis Melatonin 4.7315707874
MESH:D010954 Plasmacytoma Selenium 4.2815087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9918163543
MESH:D011230 Precancerous Conditions Cyclosporine 12.3212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 12.322563599
MESH:D011230 Precancerous Conditions Phenobarbital 12.322563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.6011118676 11896295 11222880 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.1417616702
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Arsenic 2.6516140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6519131511
MESH:D011471 Prostatic Neoplasms Cadmium 2.6517075824
MESH:D011471 Prostatic Neoplasms Curcumin 2.6512497104 10851300 18156803 18769126 15129424 18226269 11398177
MESH:D011471 Prostatic Neoplasms DDT 2.6512584743
MESH:D011471 Prostatic Neoplasms Dicofol 2.6512584743
MESH:D011471 Prostatic Neoplasms Lindane 2.6512661182 14688026
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.6517804756 14666653
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6515084515
MESH:D011507 Proteinuria Arsenic 7.4421343184
MESH:D011507 Proteinuria Tretinoin 7.4416636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7215861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 3.8812752131
MESH:D011565 Psoriasis Cyclosporine 1.9916882103
MESH:D011625 Pterygium Tretinoin 4.1916723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.0019168576
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.7214606601
MESH:D051437 Renal Insufficiency Folic Acid 4.2015728788
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.4810666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2618990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.1116849425
MESH:D012208 Rhabdomyosarcoma decitabine 9.1019155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.1016283617 16116481
MESH:D012509 Sarcoma Curcumin 3.5918462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.3916646077
MESH:D012559 Schizophrenia Folic Acid 2.8016641680
MESH:D012640 Seizures Endosulfan 7.707539098 10698677
MESH:D012640 Seizures Lindane 7.7015475178 7539098 12842176
MESH:D012640 Seizures Phenobarbital 7.7016876388 11442880 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.226407741
MESH:D018805 Sepsis Curcumin 3.5818389075
MESH:D012852 Sinusitis Phenylephrine 4.107327846
MESH:D012871 Skin Diseases Arsenic 9.7517050553 19834688 17453740 16353154 17548696 18709164 17938729 6392382 16702368 15952646 16759981
MESH:D012871 Skin Diseases Ascorbic Acid 9.7518709164
MESH:D012871 Skin Diseases Folic Acid 9.7518709164
MESH:D012871 Skin Diseases Vitamin E 9.7518709164
MESH:D012878 Skin Neoplasms Arsenic 10.9717976673 17050553 17029826 15504454 19538983 16251483
MESH:D012878 Skin Neoplasms Plant Extracts 10.9716517061 15173996
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.9716192470
MESH:D012878 Skin Neoplasms Tretinoin 10.9716467112
MESH:D012893 Sleep Disorders Melatonin 4.8716897403 18182647 16919138
MESH:D020178 Sleep Disorders, Circadian Rhythm Melatonin 6.0218078449 19452292
MESH:D007319 Sleep Initiation and Maintenance Disorders Melatonin 4.6518078449
MESH:D013088 Spermatocele Ethinyl Estradiol 3.3316709447
MESH:D013118 Spinal Cord Diseases Folic Acid 4.8916361298
MESH:D013274 Stomach Neoplasms arsenic trioxide 9.0317007042
MESH:D013274 Stomach Neoplasms decitabine 9.0319037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 9.0318456281
MESH:D013274 Stomach Neoplasms Ethylene Dibromide 9.033768853
MESH:D013274 Stomach Neoplasms Folic Acid 9.0317171786
MESH:D013274 Stomach Neoplasms irinotecan 9.0315723263
MESH:D013274 Stomach Neoplasms Tretinoin 9.0317261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 12.9418726076
MESH:D013276 Stomach Ulcer Curcumin 12.9419188055 16631530
MESH:D013276 Stomach Ulcer Melatonin 12.9416150113 11523592 12500499
MESH:D013276 Stomach Ulcer Plant Extracts 12.9412787963 15255614 18193104 18237397 17135157
MESH:D020521 Stroke Ascorbic Acid 11.7816403987 16517955
MESH:D020521 Stroke Folic Acid 11.7816517955
MESH:D020521 Stroke Vitamin E 11.7816517955
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.8717997062
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.2320133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6415669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.5615790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 17.5419014326
MESH:D013964 Thyroid Neoplasms decitabine 17.5417967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 17.547505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 17.541399818
MESH:D013964 Thyroid Neoplasms Tretinoin 17.5416026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.2616051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.3615213294
MESH:D014202 Tremor fenvalerate 4.968952708
MESH:D014376 Tuberculosis Tretinoin 2.8316040207
MESH:D014402 Tuberous Sclerosis Sirolimus 4.9918495876 21115397
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 12.8815867355 15289314 1399818
MESH:D001749 Urinary Bladder Neoplasms Arsenic 12.8818640142 19322015 19429237 11144890 17306315 17976673 15987713
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.8812973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Curcumin 12.8818593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.8819087683 17616700
MESH:D014565 Urogenital Neoplasms Curcumin 4.6618462866
MESH:D014570 Urologic Diseases DDT 5.0216487989
MESH:D014581 Urticaria Acetaminophen 2.4310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.1516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.7314692618
MESH:D014604 Uveal Neoplasms decitabine 10.7917785578
MESH:D014604 Uveal Neoplasms Tretinoin 10.7916752155
MESH:D014605 Uveitis Cyclosporine 10.031336536
MESH:D014605 Uveitis Sirolimus 10.031336536
MESH:D014652 Vascular Diseases Arsenic 4.1317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.1618097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.7118097624
MESH:D014820 Vitiligo Tretinoin 3.4916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6315886252
MESH:D009396 Wilms Tumor Tretinoin 3.4516287080
MESH:D014947 Wounds and Injuries Plant Extracts 3.7620213670 19894650
MESH:D014985 Xerophthalmia Cyclosporine 3.8317120751
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
KEGG:00460 Cyanoamino acid metabolism
KEGG:00480 Glutathione metabolism
KEGG:01100 Metabolic pathways
KEGG:00430 Taurine and hypotaurine metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00143 - BSS Plus Dietary supplement;Micronutrient
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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