AutismKB 2.0

Annotation Detail for GGT5


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Basic Information Top
Gene Symbol:GGT5 ( DKFZp566O011,FLJ92733,GGT-REL,GGTLA1 )
Gene Full Name: gamma-glutamyltransferase 5
Band: 22q11.23
Quick LinksEntrez ID:2687; OMIM: 137168; Uniprot ID:GGT5_HUMAN; ENSEMBL ID: ENSG00000099998; HGNC ID: 4260
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-4041gamma-glutamyl cycle
PWY66-375leukotriene biosynthesis
Pathway IDPathway Name
hsa00480Glutathione metabolism
hsa00590Arachidonic acid metabolism
hsa00430Taurine and hypotaurine metabolism
hsa00450Selenoamino acid metabolism
hsa01100Metabolic pathways
hsa00460Cyanoamino acid metabolism
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GGT5 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GGT5 mRNAdecreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GGT5 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.886695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.7319183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9920146248 17474063
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9912907637 21507988 12619106
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1420419170
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0916530937
MESH:D005234 Fatty Liver pirinixic acid 3.2520131406 19236843
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8520471113
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6418467677 16221962 19772884 19176532
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.1918177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.1920195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 8.1915890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.998603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.5114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5120464547 18520028 18569708 20135361 18816296 20869020 20064080 6695378 17053015
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5316381670
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4411141357
MESH:D009369 Neoplasms pirinixic acid 5.4417405874
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5410029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3117053015
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
KEGG:00460 Cyanoamino acid metabolism
KEGG:00480 Glutathione metabolism
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00430 Taurine and hypotaurine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162389442
    • No data
    No data
    Releated drug ID Related drug Name
    PA449780glutathione
    PA449789glycine
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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