AutismKB 2.0

Annotation Detail for GHRHR


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Basic Information Top
Gene Symbol:GHRHR ( GHRFR,GRFR,IGHD1B )
Gene Full Name: growth hormone releasing hormone receptor
Band: 7p14.3
Quick LinksEntrez ID:2692; OMIM: 139191; Uniprot ID:GHRHR_HUMAN; ENSEMBL ID: ENSG00000106128; HGNC ID: 4266
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500430Glucagon-type ligand receptors
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
1934Cancer
2021Acromegaly
Desease Name
elevated response to GHRH by pituitary somatotrophinomas
No data
Desease Name
Growth hormone deficiency, isolated, type IB
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of GHRHR mRNAincreases expression 20406850
D000082 Acetaminophen GHRHR gene mutant form results in decreased susceptibility to Acetaminophendecreases response to substance 17521389
D000082 Acetaminophen GHRHR protein affects the reaction [NR1I2 protein affects the susceptibility to Acetaminophen]affects reaction|affects response to substance 17521389
D000082 Acetaminophen GHRHR protein affects the reaction [NR1I3 protein affects the susceptibility to Acetaminophen]affects reaction|affects response to substance 17521389
D019386 Alendronate Alendronate affects the expression of GHRHR mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GHRHR mRNAaffects expression 16483693
C032036 bromobenzene GHRHR gene mutant form results in decreased susceptibility to bromobenzenedecreases response to substance 17521389
D002251 Carbon Tetrachloride GHRHR gene mutant form results in increased susceptibility to Carbon Tetrachlorideincreases response to substance 17521389
D004958 Estradiol Estradiol results in increased expression of GHRHR proteinincreases expression 16015026
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GHRHR mRNAaffects expression 16079270
D005419 Flavonoids Flavonoids results in increased expression of GHRHR mRNAincreases expression 18035473
D010758 Phosphorus Phosphorus results in decreased expression of GHRHR mRNAdecreases expression 17715259
D020849 Raloxifene Raloxifene affects the expression of GHRHR mRNAaffects expression 16079270
D015049 Zoxazolamine GHRHR gene mutant form results in decreased susceptibility to Zoxazolaminedecreases response to substance 17521389
D015049 Zoxazolamine GHRHR protein affects the reaction [NR1I3 protein affects the susceptibility to Zoxazolamine]affects reaction|affects response to substance 17521389
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Estradiol 4.3011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3014692618
MESH:D000419 Albuminuria Raloxifene 4.7217308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5615800139
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001930 Brain Injuries Raloxifene 4.6116580743
MESH:D001943 Breast Neoplasms Estradiol 2.2812948864 14630087 17289903 19861407 16675129 18497071 17018787 17261762
MESH:D001943 Breast Neoplasms Raloxifene 2.2816912660 15775269 15572757 17242785 15758505 17595753 17893378 17952589 17440819 16837676 17261762 17049068
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216124888 16227642 3786805 15673190 10355542 16050911 16011737 15700767 16097048 15721981 16192424 18705752
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.683084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6818788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6816924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1717572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5215775269
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.916135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9118566989
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9516919318 11677210 16105132 17110522 17681005 15861022 17333356
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D003928 Diabetic Nephropathies Estradiol 9.3419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.3415920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2816393943 16109766 12594235 17522070 19164858 10915739 2444490 11461765 16227642 14986274 19923254 18071297 11834606 12705907 12153990 19085960 12392966 19416960 11529661 15968718 18713872 14725611 10663392 11287661 10774834 16177239 19370779 17906064 16485898 12958197 17562736 19739265 11743745 16081117 11739529 16781746 19420014 11421492 14550746 15619225 12540782
MESH:D056486 Drug-Induced Liver Injury bromobenzene 9.2812628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.2815968718 15998439 7440962 10092053 2869522 11566570 4309450 3732212 9327722 19336974 21278145 15027814 16177239 6623471 16227642 7120509 17522070 3786805 19085960 7179309 6884620 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004487 Edema Raloxifene 3.4415860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.5412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.5415845917
MESH:D016889 Endometrial Neoplasms Estradiol 3.0511473722 18566989 19148513
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.8116045604 12795759 19224547 12631006 17595544 16239168 61145 15959796
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8115345470
MESH:D005234 Fatty Liver Raloxifene 13.8117473493
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5918705752
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D006331 Heart Diseases Raloxifene 3.6111110106
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006930 Hyperalgesia Acetaminophen 8.4716870215
MESH:D006930 Hyperalgesia Alendronate 8.4716769263
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006973 Hypertension Raloxifene 2.9015787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Flavonoids 2.7017296493
MESH:D007333 Insulin Resistance Estradiol 3.0316393666 16627594
OMIM:612781 ISOLATED GROWTH HORMONE DEFICIENCY, TYPE IB marker/mechanism
MESH:D007674 Kidney Diseases Acetaminophen 6.0812587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.0815618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms Estradiol 7.6715610895
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8616943688 16239168 17334410 17157831 11408273 21278145 17174718 16221502 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4715338365 18472332 17714472 16011737 17805973 12609069 16136751 14748882 12898905 18420326 15931870 18277467 17698563 16015684 15818738 15959796 12666154 18395095 15730626 17976157 17708605 11481614 17823541 12632512 14512876 10355542 15370692 16097048 12389079 17565644 12632514 18481824 12546737 18418968 12649538 16192424 15673190 15893842 15925388 15123356 18006644 15052691 14620537 18339082 18054572 15362042 17481882 15876570 16638106 20821823 12445418 18156304 17922224 13678700 17557913 18395914 18376398 17721639 18412020 17525996 17869086 16033810 18251166 16027843 14716496 18210741 17761835 18263696 18472094 16248980 17900296 17631135 18205269 18317297 17640975 14724832 17766677 18429990 16116963 14716833 12958196 12586293 18187930 15996030 15650968 12667390 18705752 17944888 12741479 18166357 15057751 12445421 18279442
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.4714716833 14659978
MESH:D008107 Liver Diseases Acetaminophen 3.9816610002 12587719 11587558 12969438 16611625 19784758 19460945 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9815720792 16246199 17285989 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.7616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.7614706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.687678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6819294768
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.142876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1412014681 15583823
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6216891317 11807958 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5116497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3616810080
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.017678174 18551238
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009421 Nervous System Malformations Estradiol 3.7816427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5316049721
MESH:D010024 Osteoporosis Alendronate 8.0117882678
MESH:D010024 Osteoporosis Raloxifene 8.0117882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3415758505 15579764 17823083 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010243 Paralysis Zoxazolamine 7.0816109766
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.3116740699
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3115731164 16220300 16536755
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D020521 Stroke Raloxifene 3.9116837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013978 Tibial Fractures Estradiol 14.3019048282
MESH:D013978 Tibial Fractures Raloxifene 14.3019048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3416049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.3417572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00010 agonist Sermorelin Anabolic Agents;Hormone Replacement Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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