AutismKB 2.0

Annotation Detail for GHSR


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Basic Information Top
Gene Symbol:GHSR ( - )
Gene Full Name: growth hormone secretagogue receptor
Band: 3q26.31
Quick LinksEntrez ID:2693; OMIM: 601898; Uniprot ID:GHSR_HUMAN; ENSEMBL ID: ENSG00000121853; HGNC ID: 4267
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1783Testicular tumor
1856Obesity
1934Cancer
1986Eating disorder
Desease Name
CARDIOVASCULAR
left ventricular hypertrophy
Desease Name
Height
Desease Name
Short stature
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GHSR mRNAaffects expression 16483693
D002330 Carmustine Carmustine results in decreased expression of GHSR mRNAdecreases expression 15980968
C099555 CD 437 CD 437 results in decreased expression of GHSR mRNAdecreases expression 12958071
D004041 Dietary Fats Dietary Fats results in increased expression of GHSR mRNAincreases expression 18721800
D010269 Paraquat Paraquat results in decreased expression of GHSR mRNAdecreases expression 17077588
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of GHSR mRNAaffects expression 15977195
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.2211874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001932 Brain Neoplasms Carmustine 4.6916187019
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 16120746 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 8697196 15668235 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D004067 Digestive System Neoplasms marker/mechanism 18064392
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Dietary Fats 3.5618296743 19004024 17967931 19551842
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Dietary Fats 10.0518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.0520067830
MESH:D005909 Glioblastoma Carmustine 4.1216187019
MESH:D005911 Gliosis Paraquat 5.6811124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5715340226 16959395 8697196 18606429 16354765
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007248 Infertility, Male Paraquat 3.454850670
MESH:D007249 Inflammation Dietary Fats 5.4020412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4012878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.3011836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008545 Melanoma Carmustine 2.9012393984
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009410 Nerve Degeneration Paraquat 3.9616893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009765 Obesity Dietary Fats 2.3417217161 18674790 21332399 20132043 20518802 11836018 18457598 19632207 16723640
MESH:D010051 Ovarian Neoplasms CD 437 3.3917474084
MESH:D010300 Parkinson Disease Paraquat 2.9116510128 12911755 11124998 11445065 15824117 15451049 11181820 16140633
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.8516190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D011014 Pneumonia Paraquat 4.9112504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11896295 11118676 11399792
MESH:D011658 Pulmonary Fibrosis Paraquat 3.0117997886 16324872
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.2611700416
MESH:D012135 Respiratory Sounds Paraquat 4.4711874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012162 Retinal Degeneration Paraquat 4.1016458197
OMIM:604271 SHORT STATURE, IDIOPATHIC, AUTOSOMAL marker/mechanism
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D001749 Urinary Bladder Neoplasms CD 437 3.4916720286
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28677
    • No data
    Releated disease ID Related disease Name
    PA162370415metabolic syndrome
    PA445131Obesity
    PA443309Alcoholism
    PA446479Hypertrophy, Left Ventricular
    Releated drug ID Related drug Name
    PA448073ethanol
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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