AutismKB 2.0

Annotation Detail for GIF


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Basic Information Top
Gene Symbol:GIF ( IF,IFMH,INF,TCN3 )
Gene Full Name: gastric intrinsic factor (vitamin B synthesis)
Band: 11q12.1
Quick LinksEntrez ID:2694; OMIM: 609342; Uniprot ID:IF_HUMAN; ENSEMBL ID: ENSG00000134812; HGNC ID: 4268
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Intrinsic factor deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GIF mRNAaffects expression 16483693
D005609 Free Radicals GIF protein affects the metabolism of Free Radicalsaffects metabolic processing 11750760
D017665 Hydroxyl Radical GIF protein affects the metabolism of Hydroxyl Radicalaffects metabolic processing 11750760
C006253 pirinixic acid pirinixic acid results in increased expression of GIF mRNAincreases expression 12832660
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of GIF mRNAaffects cotreatment|affects expression 16979875
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of GIF mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000169 Acrodermatitis Zinc 5.8716889938 17190629 17202136
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000544 Alzheimer Disease Zinc 2.8116410023 16325427 16580781 17119284
MESH:D000755 Anemia, Sickle Cell Zinc 5.2816916123
MESH:D001249 Asthma Zinc 3.0317085522
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001930 Brain Injuries Zinc 5.1117109824
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 5.3818922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.3816543248
MESH:D002318 Cardiovascular Diseases Zinc 3.8716936243
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D019465 Craniofacial Abnormalities Zinc 2.4419302082
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003920 Diabetes Mellitus Zinc 4.4916479319
MESH:D004487 Edema pirinixic acid 8.0912083418
MESH:D004487 Edema Tetradecanoylphorbol Acetate 8.099599246 16716910 7812673 15177302 8113982 11698051 8273558
MESH:D004938 Esophageal Neoplasms Zinc 2.9216543248
MESH:D005234 Fatty Liver pirinixic acid 3.0920131406 19236843
MESH:D005756 Gastritis Zinc 5.3217241300
MESH:D006130 Growth Disorders Zinc 4.1517217573
MESH:D006333 Heart Failure pirinixic acid 7.7520558911
MESH:D006333 Heart Failure Zinc 7.7517162251
MESH:D006335 Heart Injuries Zinc 6.2917074742
MESH:D016481 Helicobacter Infections Zinc 4.8817241300
MESH:D006527 Hepatolenticular Degeneration Zinc 5.1117276780
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 18467677 19772884 16221962
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 3.2315177302 7812673 11698051 8273558 7562506
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
OMIM:261000 INTRINSIC FACTOR DEFICIENCY marker/mechanism
MESH:D007511 Ischemia Zinc 5.0516584753
MESH:D007674 Kidney Diseases Zinc 3.4816960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.7516518626
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9120007298 15890375 16377806
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 2.4811807781
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 7.158985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 7.1512773700
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.2215976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.7112065085 8330346 18404319 18922899
MESH:D011225 Pre-Eclampsia Zinc 4.4217114810
MESH:D011471 Prostatic Neoplasms Zinc 3.7716606632 12429649 16700911 16517595
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012162 Retinal Degeneration Zinc 4.3616584753
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 3.4018404319 12065085 8985016 11807781 8330346
MESH:D014062 Tongue Neoplasms Zinc 4.7016543248
Pathway ID Pathway Name
KEGG:04977 Vitamin digestion and absorption
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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