AutismKB 2.0

Annotation Detail for PABPC1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PABPC1 ( PAB1,PABP,PABP1,PABPC2,PABPL1 )
Gene Full Name: poly(A) binding protein, cytoplasmic 1
Band: 8q22.3
Quick LinksEntrez ID:26986; OMIM: 604679; Uniprot ID:PABP1_HUMAN; ENSEMBL ID: ENSG00000070756; HGNC ID: 8554
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of proteins
Metabolism of RNA
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500864Translation initiation complex formation
500855Deadenylation of mRNA
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1756Esophageal tumor
1993Esophagus cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PABPC1 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PABPC1 mRNAdecreases expression 12958071
C065250 4-hydroxy-equilenin 4-hydroxy-equilenin results in increased expression of PABPC1 mRNAincreases expression 15135645
D000082 Acetaminophen Acetaminophen affects the expression of PABPC1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PABPC1 mRNAdecreases expression 20504355
C099555 CD 437 CD 437 results in decreased expression of PABPC1 mRNAdecreases expression 12958071
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PABPC1 mRNAaffects cotreatment|affects expression 17602206
C121718 dicyclanil dicyclanil results in increased expression of PABPC1 mRNAincreases expression 15664270
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PABPC1 mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PABPC1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PABPC1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PABPC1 mRNAincreases expression 17108234
D005419 Flavonoids Flavonoids results in decreased expression of PABPC1 mRNAdecreases expression 18035473
D008713 Methimazole Methimazole results in increased expression of PABPC1 mRNAincreases expression 17403546
17399805
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to PABPC1 protein]affects binding|increases reaction 17220478
C421324 pateamine A pateamine A affects the localization of PABPC1 proteinaffects localization 16951406
C494474 perchlorate perchlorate results in increased expression of PABPC1 mRNAincreases expression 17399805
17403546
D011441 Propylthiouracil Propylthiouracil results in increased expression of PABPC1 mRNAincreases expression 17399805
17403546
C017947 sodium arsenite sodium arsenite affects the localization of PABPC1 proteinaffects localization 16951406
D018038 Sodium Selenite Sodium Selenite results in increased expression of PABPC1 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PABPC1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PABPC1 mRNAincreases expression 18796159
D014810 Vitamin E Vitamin E results in decreased expression of PABPC1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7615322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1020127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1014692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.466695378
MESH:D000236 Adenoma Diethylnitrosamine 6.466695378 10737359
MESH:D018248 Adenoma, Liver Cell dicyclanil 17.0017162532
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.0017162532 19052882 16434500 19061943 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.0016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8217306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 8.9019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8017474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8416050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.7416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.743084413
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 8.7417162532
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.7418210153 17978847 19335982 20514400 21159647 10672840 18785209 19208518 17162532 18691550 11831363 16502159 16779866 16681979 18971187 18788625 19394651 19701751 16698587 20432363 3084413 16569478 20512989 18056438 16807293 17761372 20101231 19171122 18978308 17055752 18665156 18393292 20935162 19539802 19052882 16328049 19383236 16878318 19519916 18506893 19107877 16935385 3581430 17173139 16540662 19919837 19418558 20727157 17428255 17138121 20007298 16288022 18494052 20214788 10737359 19822196 16830150 20524982 20084675
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.7415276417 17306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5120419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.5118572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3218670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.5717174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.5719524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8111677210 17681005 15861022 17110522 16105132 17333356 16919318
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.078697196 15340226 16354765 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4510048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4519769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9318551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7016285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1517107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.7318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.7312958197 12540782 10774834 10663392 15968718 11743745 14986274 15619225 16081117 12153990 16109766 19420014 11287661 11739529 16227642 14725611 18071297 17562736 11461765 19923254 19416960 14550746 11834606 19370779 19085960 2444490 12705907 16781746 16393943 19164858 17522070 16485898 11421492 12392966 17906064 18713872 10915739 11529661 16177239 19739265 12594235
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.7319107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 11.7315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.7320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:C538011 Eales disease Vitamin E 4.629068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1012538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.949294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0416302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver Diethylnitrosamine 7.4321071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.4315345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8620067830
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D006042 Goiter perchlorate 5.2218801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.8420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.8411294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 10.8416080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8116120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6716863852 16490937
MESH:D006689 Hodgkin Disease sodium arsenite 3.0812676792
MESH:D019584 Hot Flashes Vitamin E 3.8914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9616959395 18606429 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718850075 18670907
MESH:D006980 Hyperthyroidism Methimazole 5.5314678291
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216569931 16945680
MESH:D007037 Hypothyroidism Methimazole 11.6618031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.668137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4417937319
MESH:D007248 Infertility, Male sodium arsenite 6.4415346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 8.0418785209
MESH:D007249 Inflammation Flavonoids 8.0417296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0412200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.1316624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.2214714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007674 Kidney Diseases Acetaminophen 9.7715629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 9.7720008137
MESH:D007674 Kidney Diseases Vitamin E 9.7712488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 2.9016705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7819638242 20032147 18407596 18522880 18665156
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3116169303
MESH:D008107 Liver Diseases Acetaminophen 3.8312969438 12587719 19014921 19460945 19784758 16610002 16611625 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8317034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1616871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.5720195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 17.5717602206
MESH:D008113 Liver Neoplasms dicyclanil 17.5720118626
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.5721071580 21047994 20452335 20492335 18978307 9163691 18648771 18644402 19426721 19073162 2422723 19090486 12771043 10737359 19499222 19850985 2862719 19256749 15175105 19551842 19638242 16942905 20118626 20434301 20101389 19812893 18977376 19996281 19294768 19255062 12112319 15885732 21278145 18754104 20137499 19427195 20501860 20405173 19254457 21167192 19642983 20583210 19690152 19833225
MESH:D008113 Liver Neoplasms sodium arsenite 17.5716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.5716984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.5818282651 18079962 18775883 19004024 18093689 17174075 17854601 19009564 2563599 19519916 21159647 16267830 18308698 9362446 16842330 19539802 19126423 17942915 18164116 18544905 18253720 3124819
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5812151625
MESH:D008171 Lung Diseases sodium arsenite 7.2419095001
MESH:D008171 Lung Diseases Vitamin E 7.2416863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4718520028 18569708 6695378 18816296 20135361 20464547 20064080 17053015 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.4720970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 6.4719931552 15276417 17306315 17077188 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4711884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.4711062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9714737004
MESH:D008545 Melanoma sodium arsenite 2.0216487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7718551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.539029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8811141357
MESH:D009369 Neoplasms sodium arsenite 4.8811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1314600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0812854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.9320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0420387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3512819281 16049721
MESH:D010051 Ovarian Neoplasms CD 437 5.1517474084
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1517306315 15276417
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3916540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.472563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1111896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0917292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0916039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0918760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0915084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.2315861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4718551238
MESH:D012871 Skin Diseases Vitamin E 2.4218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.1619755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 9.1619524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8616709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7312854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3120155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3118456281
MESH:D020521 Stroke Vitamin E 3.4516517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.187505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.1815710170
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.6916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.6917053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 11.6916720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.6916712894 16452187 17306315 11723127
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2310091137
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6911813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:71 Gene Expression
REACT:17015 Metabolism of proteins
REACT:21257 Metabolism of RNA
KEGG:03015 mRNA surveillance pathway
KEGG:03018 RNA degradation
KEGG:03013 RNA transport
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA32880
    • No data
    No data
    Releated drug ID Related drug Name
    PA451365sirolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved