AutismKB 2.0

Annotation Detail for AKAP8L


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Basic Information Top
Gene Symbol:AKAP8L ( DKFZp434L0650,HA95,HAP95,NAKAP,NAKAP95 )
Gene Full Name: A kinase (PRKA) anchor protein 8-like
Band: 19p13.12
Quick LinksEntrez ID:26993; OMIM: 609475; Uniprot ID:AKP8L_HUMAN; ENSEMBL ID: ENSG00000011243; HGNC ID: 29857
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of AKAP8L mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AKAP8L mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of AKAP8L mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of AKAP8L mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AKAP8L mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of AKAP8L mRNAincreases expression 20382639
D004040 Dietary Carbohydrates Dietary Carbohydrates results in increased expression of AKAP8L mRNAincreases expression 17490981
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of AKAP8L mRNAdecreases expression 15171707
D007657 Ketone Bodies Ketone Bodies results in increased expression of AKAP8L mRNAincreases expression 16807920
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3311798837 19825857
MESH:D000686 Amyloidosis Diethylstilbestrol 4.7615469931
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9116206674
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.6017129689 15324884
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.2216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.2216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.223084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 9.2215073043 14691202 11135700 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 9.2216924424 15948411
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.186135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1820889678
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8416002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5319923254 14725611 17522070 19416960 2444490 18071297 19085960 11461765 16227642 12153990 12594235 16781746 15968718 17906064 11287661 18713872 11421492 12705907 16109766 11529661 16081117 16393943 19739265 12392966 14986274 16485898 16177239 11743745 10915739 17562736 19420014 19370779 19164858 10663392 12958197 14550746 15619225 10774834 11834606 12540782 11739529
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.0316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.6115700306 16804899
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6320426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6312903497
MESH:D005234 Fatty Liver arsenic trioxide 3.5315073043
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7916002989 16534752 16513791 16611131 15751030
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.2816452187
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7412960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 4.8916002989
MESH:D007246 Infertility Diethylstilbestrol 4.6415036965
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.6716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.6716705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 13.6714681315 15003126 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 4.3717184923
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1717050201 20471514 16467208 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3616330433 19035177 15336539 12018890 12679006 19642359 17869043 16891316 11161223 9834237 16966277 16112521 19225113 17217047 16331271 12712474 15748426 15213294 15622746 11468182 16823087 17649720 19075265 17712046 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 16611625 19014921 12969438 12587719 11587558 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.987678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.9814682389
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.9816712894 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.432876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.4320377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.4915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6415700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.8916002989
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2714977855 19417148 11468182 19549372 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616882451 16105982
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009369 Neoplasms Diethylstilbestrol 2.8715313581
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.4211399458
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4719769630 12452020 16624393
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5915580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.5514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.9815687265 16977796
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.4517184923
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3419131511
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.3417136230 15846301 15046698
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D013088 Spermatocele Diethylstilbestrol 5.0916002989 16709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.6216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.6216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.6212845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 12.6216712894 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.2616175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.5514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.3515809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7416002989 16513791
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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