AutismKB 2.0

Annotation Detail for FGF22


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Basic Information Top
Gene Symbol:FGF22 ( - )
Gene Full Name: fibroblast growth factor 22
Band: 19p13.3
Quick LinksEntrez ID:27006; OMIM: 605831; Uniprot ID:FGF22_HUMAN; ENSEMBL ID: ENSG00000070388; HGNC ID: 3679
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by Insulin receptor
Signaling by FGFR
No data
Pathway IDPathway Name
P00021FGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FGF22 mRNAaffects expression 16483693
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of FGF22 mRNAdecreases expression 17589599
D003976 Diazinon Diazinon results in decreased expression of FGF22 mRNAdecreases expression 17589599
D004026 Dieldrin Dieldrin results in increased expression of FGF22 mRNAincreases expression 19130878
D009532 Nickel Nickel affects the expression of FGF22 mRNAaffects expression 19130878
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D055371 Acute Lung Injury Nickel 4.9916166738
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 11.0316611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 11.0316487989
MESH:D001943 Breast Neoplasms Dieldrin 2.9215770527 11859874
MESH:D001943 Breast Neoplasms Nickel 2.9215986119
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.4217244072 17100760 19470301
MESH:D003877 Dermatitis, Contact Nickel 5.042952479
MESH:D004417 Dyspnea Diazinon 5.4116487989
MESH:D006505 Hepatitis Diazinon 5.0116487989
MESH:D015658 HIV Infections Nickel 3.9817263646
MESH:D007247 Infertility, Female Dieldrin 5.3410630421
MESH:D007248 Infertility, Male Diazinon 4.0412948887 16466525
MESH:D007249 Inflammation Nickel 3.5816166738
MESH:D008107 Liver Diseases Chlorpyrifos 3.1415991261
MESH:D008113 Liver Neoplasms Dieldrin 3.459539021 8742319
MESH:D009369 Neoplasms Dieldrin 3.618820588
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.3915081274
MESH:D010300 Parkinson Disease Dieldrin 3.6317291500 16112328 11181820 16809432 11445065
MESH:D011041 Poisoning Diazinon 4.7517603234
MESH:D012135 Respiratory Sounds Chlorpyrifos 5.1216611668 11874814 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.5017119214 16611668
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.706418539
MESH:D014570 Urologic Diseases Diazinon 5.8916487989
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
KEGG:05218 Melanoma
KEGG:05200 Pathways in cancer
KEGG:04810 Regulation of actin cytoskeleton
REACT:9470 Signaling by FGFR
REACT:498 Signaling by Insulin receptor
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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