AutismKB 2.0

Annotation Detail for NGFRAP1


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Basic Information Top
Gene Symbol:NGFRAP1 ( BEX3,Bex,DXS6984E,HGR74,NADE )
Gene Full Name: nerve growth factor receptor (TNFRSF16) associated protein 1
Band: Xq22.2
Quick LinksEntrez ID:27018; OMIM: 300361; Uniprot ID:BEX3_HUMAN; ENSEMBL ID: ENSG00000166681; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04722Neurotrophin signaling pathway
Pathway IDPathway Name
Signalling by NGF
Pathway IDPathway Name
200103p75(NTR)-mediated signaling
No data
Pathway IDPathway Name
500611NADE modulates death signalling
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NGFRAP1 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NGFRAP1 mRNAaffects cotreatment|increases expression 18164116
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of NGFRAP1 mRNAincreases expression 17553608
D016572 Cyclosporine Cyclosporine results in decreased expression of NGFRAP1 mRNAdecreases expression 20106945
D003976 Diazinon Diazinon results in increased expression of NGFRAP1 mRNAincreases expression 19130878
D004026 Dieldrin Dieldrin results in increased expression of NGFRAP1 mRNAincreases expression 19130878
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NGFRAP1 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of NGFRAP1 mRNAincreases expression 19638242
D004958 Estradiol Estradiol results in increased expression of NGFRAP1 mRNAincreases expression 20068009
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NGFRAP1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NGFRAP1 mRNAdecreases expression 17557909
D007657 Ketone Bodies Ketone Bodies results in increased expression of NGFRAP1 mRNAincreases expression 16807920
D009532 Nickel Nickel results in decreased expression of NGFRAP1 mRNAdecreases expression 19130878
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NGFRAP1 mRNAincreases expression 16054898
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury Nickel 4.7016166738
MESH:D000230 Adenocarcinoma Estradiol 4.3011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3014692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.0819389873
MESH:D000236 Adenoma Diethylnitrosamine 7.086695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.5817162532 17620307 16434500 19061943 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5816835633
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.4916487989
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Dieldrin 2.3911859874 15770527
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3917474063
MESH:D001943 Breast Neoplasms Estradiol 2.3918497071 12948864 17261762 19861407 14630087 17289903 17018787 16675129
MESH:D001943 Breast Neoplasms Nickel 2.3915986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.0420214788 18691550 17173139 18978308 16288022 16807293 16935385 20727157 20514400 10737359 18393292 20432363 17138121 16698587 17978847 19822196 19539802 19418558 18210153 18785209 19171122 16502159 19052882 18788625 17761372 19519916 3084413 19383236 19208518 18056438 17428255 19394651 17055752 16878318 19919837 19335982 18506893 17162532 16569478 19107877 19701751 16830150 10672840 11831363 20935162 18665156 16540662 16681979 18971187 20512989 3581430 20007298 21159647 20084675 16779866 18494052 16328049 20524982 20101231
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0416924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.5917174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.5918566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.6519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.6516835633
MESH:D002779 Cholestasis Cyclosporine 8.0519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0511677210 17333356 16919318 15861022 17681005 17110522 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 15340226 15668235 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.0817100760 19470301 17244072
MESH:D003877 Dermatitis, Contact Nickel 4.752952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.8219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004417 Dyspnea Diazinon 4.9716487989
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0518566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 13.7119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.7120387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.7115345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis Diazinon 4.7016487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0316120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D015658 HIV Infections Nickel 3.8717263646
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 16354765 15340226 16959395 8697196
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Dieldrin 10.6910630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 10.6912013081
MESH:D007248 Infertility, Male Diazinon 7.1916466525 12948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1917937319
MESH:D007249 Inflammation Diethylnitrosamine 8.7318785209
MESH:D007249 Inflammation Nickel 8.7316166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7312200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0316393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.1418776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 6.1415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D007680 Kidney Neoplasms Estradiol 7.5815610895
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8820032147 19638242 18665156 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2912878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1217034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.0921295105 19389873
MESH:D008113 Liver Neoplasms Dieldrin 11.098742319 9539021
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.092422723 19638242 20118626 19254457 19090486 20137499 15885732 12771043 20501860 12112319 19073162 9163691 21167192 19833225 19294768 15175105 16942905 20452335 21071580 18754104 21047994 19690152 19996281 18977376 20405173 19812893 10737359 19426721 18978307 21278145 20492335 18648771 19427195 19256749 19255062 19499222 19642983 18644402 2862719 20101389 20434301 20583210 19850985 19551842
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0916984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.2518164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.2521159647 18544905 19519916 18775883 18253720 18079962 17174075 18093689 19009564 19539802 9362446 19126423 19004024 18164116 18282651 3124819 2563599 18308698 16842330 16267830 17942915 17854601
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2512151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.2821163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2811884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6216891317 11408345 11807958 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3616810080
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.603581430 9029167
MESH:D009369 Neoplasms Dieldrin 3.528820588
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.8916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8914600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010300 Parkinson Disease Dieldrin 3.5616112328 17291500 11445065 11181820 16809432
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D011041 Poisoning Diazinon 4.4717603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.2712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.272563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.077505956
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D014570 Urologic Diseases Diazinon 5.4516487989
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:04722 Neurotrophin signaling pathway
REACT:11061 Signalling by NGF
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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