AutismKB 2.0

Annotation Detail for NPTN


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Basic Information Top
Gene Symbol:NPTN ( DKFZp686L2477,GP55,GP65,MGC102805,SDFR1,SDR1,np55,np65 )
Gene Full Name: neuroplastin
Band: 15q24.1
Quick LinksEntrez ID:27020; OMIM: 612820; Uniprot ID:NPTN_HUMAN; ENSEMBL ID: ENSG00000156642; HGNC ID: 17867
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2069Schizophrenia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NPTN mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NPTN mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NPTN mRNAaffects expression 16483693
D003024 Clozapine Clozapine results in increased expression of NPTN mRNAincreases expression 18797397
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NPTN mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of NPTN mRNAdecreases expression 18035473
D009151 Mustard Gas Mustard Gas results in increased expression of NPTN mRNAincreases expression 15674844
C076029 olanzapine olanzapine results in increased expression of NPTN mRNAincreases expression 18797397
C006253 pirinixic acid pirinixic acid results in increased expression of NPTN mRNAincreases expression 18301758
D018038 Sodium Selenite Sodium Selenite results in decreased expression of NPTN mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NPTN mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin affects the expression of NPTN proteinaffects expression 15789344
D014635 Valproic Acid Valproic Acid results in increased expression of NPTN mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7014514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.708875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000380 Agranulocytosis Clozapine 5.1616160616 12649775 14617031
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Mustard Gas 5.0610378619
MESH:D001249 Asthma Tretinoin 5.0616456186
MESH:D001321 Autistic Disorder olanzapine 2.5717069543 18685284
MESH:D001321 Autistic Disorder Valproic Acid 2.5718940202 15238991 17688650 18985861 16609825 20603192 18396377 19232924 18775368 18316065 17157402 19460635 17507914 18558336 18177632
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.1120046352 17594078
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.7619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.7612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.7616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.198888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9816873071 16166294 16443354
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1110378619 17687719
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.641917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3116096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D002389 Catatonia olanzapine 6.3816772815 18071103
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.826135515
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9417333356 16919318 17110522 17681005 15861022 11677210 16105132
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.878697196 15340226 16354765 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 5.879407595
MESH:D003072 Cognition Disorders Clozapine 5.0717123785
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8010589399 9224671 17551590 9664655 16925845 9211117 9142499 8800419 9125849 14991402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8016575769 8888407 17688650
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D002658 Developmental Disabilities olanzapine 4.7417069543
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.5716402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5717107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.6915331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.2721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.2721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.2715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.2719641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D050171 Dyslipidemias Clozapine 4.2416402076
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:D004487 Edema Mustard Gas 11.919260866 11428647 11402378 11428631
MESH:D004487 Edema pirinixic acid 11.9112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.9111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.4018230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.263659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0516628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9718234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.666254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.183659116
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.0416938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.5415345470
MESH:D005234 Fatty Liver pirinixic acid 13.5420131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 13.5414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.238888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9720067830
MESH:D005355 Fibrosis Tretinoin 8.9717994277
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.6714991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6119772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6115340226 12621046 16120746
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16959395 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006948 Hyperkinesis Clozapine 5.0316046005
MESH:D006963 Hyperphagia olanzapine 6.3517933447
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Flavonoids 8.6017296493
MESH:D007249 Inflammation Mustard Gas 8.608975870 11428620 16001271 17524151 11428631 9260866 9357497 11428647 11402378
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6012200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 7.4816306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.4814714311
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.2117551590 15992940
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5916705839
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9316294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9316294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2016766008 19075265 17339181 19029980 17368321 17506722 16140955 17649720 19642359 16788101 17107899 16891316 17217047 17294898 16935935 19035177 17301526 19225113 15748426 17712046 16331271 12679006 9834237 17361223 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008064 Lipidoses Clozapine 4.0217567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4416248980 18397230
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.497678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.4915890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.902876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9012151625
MESH:D008133 Long QT Syndrome olanzapine 4.7920210726
MESH:D008171 Lung Diseases Mustard Gas 3.5018702808 18161513
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D008175 Lung Neoplasms Mustard Gas 2.438781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4319555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D001523 Mental Disorders Clozapine 8.9916856516
MESH:D001523 Mental Disorders olanzapine 8.9916856516
MESH:D008659 Metabolic Diseases olanzapine 5.4719142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.4819142101
MESH:D008881 Migraine Disorders Valproic Acid 3.2518765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5417596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.5417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.7418551238 7678174
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009369 Neoplasms Tretinoin 5.0316594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.839125849
MESH:D009436 Neural Tube Defects Tretinoin 7.489142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.4816359493 8888407
MESH:D009503 Neutropenia Mustard Gas 4.067688884 16761898
MESH:D009765 Obesity Clozapine 7.7719142110 18515891
MESH:D009765 Obesity olanzapine 7.7718515891
MESH:D009765 Obesity pirinixic acid 7.7720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Tretinoin 2.9716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8611896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.8620603192
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3818760546
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011537 Pruritus Ethinyl Estradiol 9.9215861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.9218058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.6711422049 12752131
MESH:D011595 Psychomotor Agitation olanzapine 5.6918685284
MESH:D011618 Psychotic Disorders Clozapine 4.2415331141
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9517266442 17620002 17894541 17720292 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.1616283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.1619155313
MESH:D012559 Schizophrenia Clozapine 5.8717667964 11763009 18806925 20452607 20168265 18855531 20521320 16141801 19369910 20580759 11151749 20107430 17123785 20521326 17726453
MESH:D012559 Schizophrenia olanzapine 5.8720107430 17726453 20521326
MESH:D012559 Schizophrenia Valproic Acid 5.8719110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 10.1418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.1418551238
MESH:D012640 Seizures Valproic Acid 10.1411044598 11738929 1511512 15475178 14763951 16876388 3137016 17978042
MESH:D012871 Skin Diseases Mustard Gas 2.7315451306 12880345 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6816192470
MESH:D012878 Skin Neoplasms Tretinoin 5.6816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D017180 Tachycardia, Ventricular olanzapine 5.4320210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0917045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1116049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Clozapine 10.5917502770 20107430 20564506 16402076 16141801 20521320
MESH:D015430 Weight Gain olanzapine 10.5917933447 20107430 19434072
MESH:D015431 Weight Loss Clozapine 5.1917933447
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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