AutismKB 2.0

Annotation Detail for FOXD3


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Basic Information Top
Gene Symbol:FOXD3 ( AIS1,Genesis,HFH2 )
Gene Full Name: forkhead box D3
Band: 1p31.3
Quick LinksEntrez ID:27022; OMIM: 611539; Uniprot ID:FOXD3_HUMAN; ENSEMBL ID: ENSG00000187140; HGNC ID: 3804
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Autoimmune disease, susceptibility to, 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FOXD3 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of FOXD3 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FOXD3 mRNAdecreases expression 17879257
C121718 dicyclanil dicyclanil results in increased expression of FOXD3 mRNAincreases expression 15664270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D018248 Adenoma, Liver Cell dicyclanil 5.7217162532
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
OMIM:607836 AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 1 marker/mechanism
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 3.0617162532
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 5.3621137059 20195826
MESH:D008113 Liver Neoplasms dicyclanil 5.3620118626
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.5817365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720464547 18816296 17053015 18569708 20135361 20064080 20869020 18520028 6695378
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.3116166281 16966607 18303189
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3311141357
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.4510923243
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1515814490 17365031 17975199 17322281
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5219755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018