AutismKB 2.0

Annotation Detail for LAT


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Basic Information Top
Gene Symbol:LAT ( LAT1,pp36 )
Gene Full Name: linker for activation of T cells
Band: 16q13
Quick LinksEntrez ID:27040; OMIM: 602354; Uniprot ID:LAT_HUMAN; ENSEMBL ID: ENSG00000213658; HGNC ID: 18874
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Hemostasis
Signaling in Immune system
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200003Fc-epsilon receptor I signaling in mast cells
200129JNK signaling in the CD4+ TCR pathway
200062TCR signaling in naive CD8+ T cells
200022TCR signaling in naive CD4+ T cells
Pathway IDPathway Name
P00053T cell activation
Pathway IDPathway Name
500481Generation of second messenger molecules
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1702Skin tumor
1712Yersinia infection
1923Generalized anxiety disorder
2146Lupus erythematosus
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in increased expression of LAT mRNAincreases expression 19784758
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of LAT mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of LAT mRNAaffects expression 19784758
D000082 Acetaminophen Acetaminophen results in decreased expression of LAT mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of LAT mRNAincreases expression 19784758
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LAT mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of LAT mRNAincreases expression 15761015
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of LAT mRNAaffects expression 17331233
C472777 bisperoxovanadium LAT protein affects the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]affects reaction|increases expression 12493747
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of LAT mRNAincreases expression 20360939
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAT mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of LAT mRNAdecreases expression 18035473
D007657 Ketone Bodies Ketone Bodies results in decreased expression of LAT mRNAdecreases expression 16807920
D008294 Malathion Malathion results in increased expression of LAT mRNAincreases expression 19784758
D009578 Nitrobenzenes Nitrobenzenes analog results in increased expression of LAT mRNAincreases expression 19784758
C006253 pirinixic acid pirinixic acid results in decreased expression of LAT mRNAdecreases expression 17426115
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAT mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9011752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3111798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3114692618
MESH:D000236 Adenoma Diethylnitrosamine 2.8710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.5919061943 19052882 18056438 17620307 16434500 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.5916835633
MESH:D000382 Agricultural Workers' Diseases Malathion 5.0317119214 11874814
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1210965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.4616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0417474063
MESH:D001943 Breast Neoplasms Malathion 2.0412762645
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0420435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3611589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.573084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.5715553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.5720007298 16698587 18788625 19519916 17761372 17428255 16878318 3581430 18393292 18785209 16288022 19335982 19701751 20084675 16502159 17055752 20727157 19383236 16328049 20524982 17173139 16807293 17978847 18056438 17138121 19822196 18210153 20512989 19539802 19394651 19052882 11831363 18506893 16830150 19171122 16681979 20514400 16540662 3084413 18665156 19208518 16779866 20214788 21159647 19919837 17162532 16569478 18971187 16935385 18691550 20935162 18494052 19418558 10672840 20432363 18978308 19107877 10737359 20101231
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1412490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.8717174075 21159647 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8117333356 16919318 11677210 17681005 17110522 16105132 15861022
MESH:D002779 Cholestasis pirinixic acid 7.8119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1115668235 15340226 12621046 8697196 16354765
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4810525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4810048152 20055451 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1315213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2417107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.1716781746 11743745 18071297 19420014 19085960 16393943 11834606 15619225 16177239 19164858 12705907 11529661 16227642 12392966 17906064 12594235 19416960 11739529 11421492 17522070 11287661 16485898 11461765 19370779 16081117 17562736 14986274 14550746 14725611 10663392 12958197 2444490 15968718 12540782 16109766 10774834 18713872 19923254 19739265 12153990 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.1719107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3212903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver arsenic trioxide 19.0115073043
MESH:D005234 Fatty Liver Diethylnitrosamine 19.0121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.0115345470
MESH:D005234 Fatty Liver pirinixic acid 19.0119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9920067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3016904648
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly pirinixic acid 8.4016221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4012621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1118606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Diethylnitrosamine 8.3918785209
MESH:D007249 Inflammation Flavonoids 8.3917296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3912878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2112587719 15629191
MESH:D007938 Leukemia arsenic trioxide 2.8415070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1416467208 19850784 17050201 16968895 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2311468182 12679006 17712046 12018890 19075265 17217047 12712474 17869043 16823087 15336539 17107899 16330433 19035177 11161223 15213294 16966277 9834237 15748426 16891316 19225113 19642359 16331271 17649720 16112521 15622746
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3916882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8419638242 20032147 18407596 18522880 18665156
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1412878042
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases Acetaminophen 3.9312969438 16611625 19460945 12587719 11587558 19014921 19784758 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9317034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 10.7614682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.7620452335 10737359 19499222 18978307 18648771 20492335 19638242 20405173 19254457 19996281 15175105 15885732 12771043 20118626 19812893 19642983 21278145 19427195 19426721 19833225 16942905 19255062 20101389 9163691 20137499 20583210 19690152 19850985 18754104 19090486 19294768 21047994 12112319 2862719 18644402 20434301 18977376 21071580 19073162 21167192 19551842 2422723 20501860 19256749
MESH:D008113 Liver Neoplasms pirinixic acid 10.7620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.9120377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.9119519916 18775883 19126423 16267830 18164116 18544905 18093689 19539802 17174075 18079962 17854601 19009564 16842330 3124819 9362446 21159647 18253720 18282651 2563599 19004024 18308698 17942915
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3715213294
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0617365036
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4011798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4021163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4011884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1918303189 16966607 16166281
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1211468182 19417148 19549372 15949261 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1616882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0016624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.583581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9617405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1310525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.2620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D020258 Neurotoxicity Syndromes marker/mechanism 19784758
MESH:D020258 Neurotoxicity Syndromes Malathion 4.8215081274
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4112452020 19769630 16624393
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3015580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3016540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1919927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.5611550810
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9310923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.582563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2719131511
MESH:D011537 Pruritus Ethinyl Estradiol 3.3615861022 16919318
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0417975199 17365031 15814490 17322281
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012135 Respiratory Sounds Malathion 5.3117119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012140 Respiratory Tract Diseases Malathion 5.5917119214
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0016646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4517007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4518456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.2619014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.267505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0115213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.4911780464 20435036 12973940 12845720
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
Pathway ID Pathway Name
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
REACT:604 Hemostasis
KEGG:04650 Natural killer cell mediated cytotoxicity
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38728
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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