AutismKB 2.0

Annotation Detail for SND1


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Basic Information Top
Gene Symbol:SND1 ( TDRD11,p100 )
Gene Full Name: staphylococcal nuclease and tudor domain containing 1
Band: 7q32.1
Quick LinksEntrez ID:27044; OMIM: 602181; Uniprot ID:SND1_HUMAN; ENSEMBL ID: ENSG00000197157; HGNC ID: 30646
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200130C-MYB transcription factor network
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SND1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SND1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SND1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SND1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SND1 mRNAincreases expression 20382639
C095105 bexarotene bexarotene results in increased expression of SND1 mRNAincreases expression 16648578
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of SND1 mRNAaffects cotreatment|increases expression 20360939
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SND1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of SND1 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of SND1 mRNAaffects cotreatment|increases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SND1 mRNAaffects cotreatment|affects expression 17602206
C008493 methylselenic acid methylselenic acid results in decreased expression of SND1 mRNAdecreases expression 18548127
D010634 Phenobarbital Phenobarbital results in increased expression of SND1 mRNAincreases expression 12082028
D018038 Sodium Selenite Sodium Selenite results in increased expression of SND1 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.566195326
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 6.786695378
MESH:D000236 Adenoma Diethylnitrosamine 6.7810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.6718056438 17620307 17162532 19061943 16434500 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.6717620307
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001321 Autistic Disorder marker/mechanism 20442744
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9720146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 1.9716818667 16344269
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9717474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.653084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6516779866 18788625 16288022 18494052 20084675 18665156 19335982 17055752 18506893 20432363 19519916 17162532 19822196 19052882 17761372 20214788 20524982 16935385 20935162 16830150 16807293 19383236 20007298 18971187 17428255 20512989 18978308 10672840 18785209 20514400 3581430 19701751 17173139 16698587 17138121 18210153 19171122 19418558 17978847 16878318 11831363 16502159 21159647 18056438 19394651 19539802 16328049 19919837 20101231 19208518 3084413 18691550 16569478 20727157 16540662 16681979 10737359 18393292 19107877
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.6520935162 1701930 20007298 6705139 17173139
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2516247446
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0720419170
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.4720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.4717174075 2727394 7505956 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D002779 Cholestasis Cyclosporine 2.9719486331
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.1718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1717522070 11743745 15619225 11739529 16177239 19416960 12958197 11529661 19420014 2444490 11421492 12540782 14986274 10774834 19085960 14550746 16081117 16485898 19739265 12153990 16227642 16781746 12392966 12594235 11287661 19370779 16109766 18713872 15968718 17562736 11834606 12705907 10915739 16393943 19923254 14725611 11461765 19164858 10663392 18071297 17906064
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.1719107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.1715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004421 Dystonia Phenobarbital 4.091851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.213659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0011558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.616401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.367750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.143659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4116530937
MESH:D005234 Fatty Liver Cyclosporine 7.9919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 7.9921071580 20387270
MESH:D005355 Fibrosis Cyclosporine 3.2412168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6920471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006529 Hepatomegaly Phenobarbital 3.5916109766
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007249 Inflammation Diethylnitrosamine 2.4118785209
MESH:D007333 Insulin Resistance Sodium Selenite 3.3314714311
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.6610783313
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.3712587719 15629191
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 10.3715369732
MESH:D007674 Kidney Diseases Cyclosporine 10.378314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5012371664
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.0416766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.7818665156 20032147 18407596 19638242 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7821047994
MESH:D008107 Liver Diseases Acetaminophen 6.6011587558 12969438 19784758 16610002 19014921 19460945 16611625 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 6.6017034775
MESH:D008107 Liver Diseases Phenobarbital 6.6019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.9721137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 10.9717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.9715175105 19833225 19426721 2862719 18644402 20452335 20501860 12771043 18977376 19427195 19294768 20405173 19090486 10737359 18978307 21278145 18754104 21071580 19850985 19073162 15885732 9163691 19690152 20137499 20583210 19812893 18648771 20492335 2422723 12112319 19255062 19499222 20101389 16942905 19996281 21047994 19254457 19638242 20118626 19256749 19642983 21167192 19551842 20434301
MESH:D008113 Liver Neoplasms Phenobarbital 10.9719482888 8742319 19812893 21047994 19073162 15975961
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.1517174075 18253720 16267830 17942915 18282651 3124819 2563599 19126423 18775883 9362446 18308698 16842330 19539802 18544905 19009564 18164116 17854601 18079962 19519916 18093689 19004024 21159647
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.156150874 1399818 17172636 18308698 2563599
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5618520028 20464547 20869020 18816296 18569708 20064080 20135361 6695378 17053015
MESH:D008175 Lung Neoplasms bexarotene 3.5617849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5620970405 21163286 20512841 6695378
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.2511161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.4619196723 19196722 15591091
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2011141357
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.9219196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5012819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3516540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3516965848
MESH:D011230 Precancerous Conditions Cyclosporine 15.7012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 15.702563599
MESH:D011230 Precancerous Conditions Phenobarbital 15.702563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6317292933
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.6316205645
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6318760546
MESH:D019310 Pseudolymphoma Phenobarbital 4.6312752131
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures Phenobarbital 6.114039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4019755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3520155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3518456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.397505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.391399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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