AutismKB 2.0

Annotation Detail for PPA2


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Basic Information Top
Gene Symbol:PPA2 ( FLJ20459,MGC49850,SID6-306 )
Gene Full Name: pyrophosphatase (inorganic) 2
Band: 4q24
Quick LinksEntrez ID:27068; OMIM: 609988; Uniprot ID:IPYR2_HUMAN; ENSEMBL ID: ENSG00000138777; HGNC ID: 28883
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00190Oxidative phosphorylation
Pathway IDPathway Name
Pyrophosphate hydrolysis
Gene Expression
No data
No data
Pathway IDPathway Name
500661Mitochondrial tRNA aminoacylation
500704Pyrophosphate hydrolysis
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPA2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PPA2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PPA2 mRNAincreases expression 20498004
D016572 Cyclosporine Cyclosporine results in decreased expression of PPA2 mRNAdecreases expression 20106945
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of PPA2 mRNA]affects reaction|decreases expression 15016801
D014303 Trinitrotoluene Trinitrotoluene affects the expression of PPA2 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.657525203
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6220464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 4.6217638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D000740 Anemia Fluorouracil 4.0217963324 16511603 15504547
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1517474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 2.1516557594 15136595 16595493 18608205 16110121 19217205 18357371
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.783084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7817971768 18930000 16332177 16799960 17045692 17088986
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8918986760 16757204 16280240 17066447
MESH:D002386 Cataract Acetaminophen 8.0710977129
MESH:D002386 Cataract Trinitrotoluene 8.0714694615 15817613
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2715001691 17172411 17725105 17287894 16510598 17016597 17169374 16340194 18772588 17018589
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017255274 17454858 15289873 17401013 14970324 16391804 18288408 20501625 17594712 16524972 17016601 18448328 17094418 17695437 18949393 15148649 16331619 18802399 18509181 18383874 16282729 16303861
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.6915095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.6618551238
MESH:D003490 Cyanosis Trinitrotoluene 12.6618551238
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7511529661 16781746 12594235 19085960 12153990 17562736 10663392 19370779 14550746 2444490 18713872 11834606 11743745 16177239 17906064 11421492 11739529 16485898 12392966 16227642 19164858 12958197 19739265 18071297 15619225 16109766 10774834 14986274 10915739 12705907 12540782 11461765 11287661 17522070 19420014 14725611 16081117 16393943 19416960 15968718 19923254
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 6.7518551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7115173087 17638652 16337965 16481741 16785472
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005355 Fibrosis Cyclosporine 3.5612168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5918337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006529 Hepatomegaly Trinitrotoluene 4.6515817613
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007248 Infertility, Male Trinitrotoluene 3.8712150543
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.3415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.3418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.0216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 14.0212371664
MESH:D007680 Kidney Neoplasms Fluorouracil 14.0216985049
MESH:D008107 Liver Diseases Acetaminophen 1.6912587719 19460945 16610002 12969438 19784758 16611625 11587558 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9420195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 4.9417045692 18383874 15113037 16603448
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5418520028 18569708 20869020 17053015 20064080 20464547 6695378 18816296 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 2.5415246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.3416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.3416757204 18986760
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.2718551238
MESH:D009336 Necrosis Trinitrotoluene 12.2718551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5211141357
MESH:D009369 Neoplasms Fluorouracil 5.5218600527 16928823 18239605
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.2516049721 12819281
MESH:D009784 Occupational Diseases Trinitrotoluene 10.2512819281 17852074 14694615
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7516929163 19003803 16500647 15113037
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1617292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1619082440 18626508
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3016160472 15538739 18286688 18722050
MESH:D012640 Seizures 2,4-dinitrotoluene 6.8918551238
MESH:D012640 Seizures Trinitrotoluene 6.8918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4910029692 19755658
MESH:D013163 Splenomegaly Trinitrotoluene 5.6215817613
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.482093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4819015929 17172411 16951190 19084572 17522103 15786421 16424979 18567086 18396642 17498489
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3116049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3117053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
REACT:71 Gene Expression
KEGG:00190 Oxidative phosphorylation
REACT:21259 Pyrophosphate hydrolysis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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