AutismKB 2.0

Annotation Detail for DAPP1


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Basic Information Top
Gene Symbol:DAPP1 ( BAM32,DKFZp667E0716 )
Gene Full Name: dual adaptor of phosphotyrosine and 3-phosphoinositides
Band: 4q23
Quick LinksEntrez ID:27071; OMIM: 605768; Uniprot ID:DAPP1_HUMAN; ENSEMBL ID: ENSG00000070190; HGNC ID: 16500
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04662B cell receptor signaling pathway
No data
Pathway IDPathway Name
200005BCR signaling pathway
200098Class I PI3K signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DAPP1 mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DAPP1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of DAPP1 mRNAdecreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in increased expression of DAPP1 mRNAincreases expression 20458559
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DAPP1 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DAPP1 mRNAincreases expression 19465110
D014303 Trinitrotoluene Trinitrotoluene affects the expression of DAPP1 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.9211752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.927525203
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3411798837 19825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.9916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.9912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.787296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7814691202 15553829 16217749 11135700 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18850075 18670907
MESH:D002386 Cataract Trinitrotoluene 4.0214694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.947505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.5219486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.5219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 15340226 12621046 8697196 15668235
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 10.1217141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 10.1215095906
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.4518551238
MESH:D003490 Cyanosis Trinitrotoluene 12.4518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1512868966 8970840 2524372 11298694 8156756 11906362 18759878 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.588291058 7440962 6679447 18289764 16192314 18692083 18648102 6482804 9328219 11289319 1440618 9022650 9653073
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.5820420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.5821346803 18551238
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.673581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6712903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver arsenic trioxide 8.6715073043
MESH:D005234 Fatty Liver pirinixic acid 8.6720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly pirinixic acid 16.6916221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.6915340226 16120746 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 16.6915817613
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4915340226 18606429 8697196 16959395 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007248 Infertility, Male Trinitrotoluene 3.8512150543
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.156582329
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1716467208 20471514 19850784 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3815748426 16112521 16966277 12018890 15336539 19035177 19075265 9834237 16330433 11468182 15622746 17217047 11161223 16823087 17869043 12712474 19225113 19642359 12679006 17649720 16331271 17107899 17712046 15213294 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2012878042
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8714682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.8716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.753712494 1399818 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.7520377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3619825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3619555203 11884234
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2919549372 19417148 11468182 15949261 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.0418551238
MESH:D009336 Necrosis Trinitrotoluene 12.0418551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.826679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.8210525206
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.7812819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.784026338 6482804
MESH:D009784 Occupational Diseases Trinitrotoluene 16.7812819281 17852074 14694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4712452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2319131511
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.8118551238
MESH:D012640 Seizures Trinitrotoluene 6.8118551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013163 Splenomegaly Trinitrotoluene 5.5615817613
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.867505956 1399818 3712494 6582329 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.8619014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.858074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.8511780464 20435036 12973940 12845720
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
KEGG:04662 B cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01863 - Inositol 1,3,4,5-Tetrakisphosphate
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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