AutismKB 2.0

Annotation Detail for FOXP1


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Basic Information Top
Gene Symbol:FOXP1 ( 12CC4,FLJ23741,MGC12942,MGC88572,MGC99551,QRF1,hFKH1B )
Gene Full Name: forkhead box P1
Band: 3p13
Quick LinksEntrez ID:27086; OMIM: 605515; Uniprot ID:FOXP1_HUMAN; ENSEMBL ID: ENSG00000114861; HGNC ID: 3823
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1901Endometriosis
1944Breast cancer
2031Endometrial cancer
2075Heart failure
2239Lymphoma
Desease Name
ADHD
PSYCH
attention-deficit hyperactivity disorder
Desease Name
Attention deficit hyperactivity disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FOXP1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FOXP1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of FOXP1 mRNAaffects expression 17562736
C430898 AGN 194204 AGN 194204 results in increased expression of FOXP1 mRNAincreases expression 16339527
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FOXP1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FOXP1 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of FOXP1 mRNAaffects expression 17484886
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of FOXP1 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FOXP1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FOXP1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of FOXP1 mRNAincreases expression 17426115
D018038 Sodium Selenite Sodium Selenite results in increased expression of FOXP1 mRNAincreases expression 18175754
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of FOXP1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8615238991 16609825 17507914 17157402 18558336 18775368 18985861 19232924 18316065 19460635 18177632 18396377 20603192 18940202 17688650
MESH:D001714 Bipolar Disorder Valproic Acid 3.1417594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0220146248 17474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516011737 15673190 3786805 15700767 18705752 15721981 16124888 16227642 16192424 10355542 16050911 16097048
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.713084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7118788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9620889678
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 21572417
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.7821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.7821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.7811287661 16081117 11529661 18071297 10915739 16109766 12705907 11461765 10663392 19416960 17906064 11834606 12392966 16227642 18713872 14986274 17562736 16177239 19370779 19739265 19420014 14725611 12153990 16781746 19923254 12958197 11743745 17522070 15619225 11421492 14550746 16485898 15968718 12594235 19164858 12540782 16393943 19085960 2444490 11739529 10774834
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.784309450 15998439 10915739 11566570 7440962 6623471 21278145 6884620 2869522 3732212 17522070 7179309 15968718 10092053 9327722 19336974 16177239 3786805 19085960 7120509 16227642 15027814
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 15.7815131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.781733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.716426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4616530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.9412795759 19224547 15959796 17595544 61145 16239168 12631006 16045604
MESH:D005234 Fatty Liver pirinixic acid 13.9420131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 13.9419224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.298888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6318705752
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.1719772884 19176532 16221962 18467677
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8016612254
MESH:D007333 Insulin Resistance pirinixic acid 7.6016306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6014714311
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8816943688 16221502 16239168 21278145 11408273 11903743 17174718 17157831 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3615996030 17557913 15362042 12632514 12741479 17869086 18205269 14512876 12586293 15730626 17721639 14716496 15123356 15925388 18339082 12546737 18279442 20821823 10355542 14620537 17708605 17823541 18418968 12666154 16027843 18210741 15057751 17922224 16033810 12445418 15876570 12389079 17976157 12898905 18317297 17481882 16011737 16015684 18420326 15370692 12445421 17698563 17640975 16638106 18395095 14748882 12609069 18006644 14724832 18395914 15893842 16248980 14716833 11481614 12958196 18472332 15959796 16136751 18187930 18376398 17565644 17805973 16116963 15338365 18481824 17761835 17944888 18412020 18429990 18472094 17766677 15931870 18156304 15673190 18705752 18251166 15052691 12649538 18263696 17714472 15650968 18277467 13678700 18054572 18166357 15818738 16097048 17525996 17631135 17900296 16192424 12667390 12632512
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3615474484
MESH:D008107 Liver Diseases Acetaminophen 4.0012969438 11587558 19460945 12587719 19014921 16610002 19784758 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0015720792 17285989 15830285 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8516899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.087678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0821137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.0819294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.0816377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.206135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2015583823 12014681
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618569708 20064080 18816296 20869020 6695378 17053015 20464547 18520028 20135361
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008881 Migraine Disorders Valproic Acid 3.2918803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.007678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.2116359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0220603192
MESH:D011471 Prostatic Neoplasms AGN 194204 2.6716000583
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6717292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6718760546
MESH:D019310 Pseudolymphoma Valproic Acid 4.7612752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 10.3718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.3718551238
MESH:D012640 Seizures Valproic Acid 10.3711044598 3137016 11738929 1511512 16876388 14763951 17978042 15475178
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4319755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5616049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5617053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014820 Vitiligo marker/mechanism 20526340
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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