Annotation Detail for EIF2AK1
Basic Information Top
| Gene Symbol: | EIF2AK1 ( HCR,HRI,KIAA1369 ) |
|---|---|
| Gene Full Name: | eukaryotic translation initiation factor 2-alpha kinase 1 |
| Band: | 7p22.1 |
| Quick Links | Entrez ID:27102; OMIM: NA; Uniprot ID:E2AK1_HUMAN; ENSEMBL ID: ENSG00000086232; HGNC ID: 24921 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Diseases/Disorders| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of EIF2AK1 mRNA | affects expression | 16483693 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of EIF2AK1 mRNA | decreases expression | 18042831 |
| C020771 | methylmercury hydroxide | methylmercury hydroxide results in increased expression of EIF2AK1 mRNA | increases expression | 20493249 |
| C041786 | palm oil | palm oil results in decreased expression of EIF2AK1 mRNA | decreases expression | 18042831 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 4.19 | 18287403 | |
| MESH:D001161 | Arteriosclerosis | Dietary Fats | 4.45 | 15238619 | |
| MESH:D001943 | Breast Neoplasms | Dietary Fats | 2.24 | 20435547 | |
| MESH:D050171 | Dyslipidemias | Dietary Fats | 3.73 | 18367378 | |
| MESH:D005234 | Fatty Liver | Dietary Fats | 3.66 | 17967931 18296743 19551842 19004024 | |
| MESH:D005355 | Fibrosis | Dietary Fats | 4.08 | 18296743 | |
| MESH:D006937 | Hypercholesterolemia | Dietary Fats | 4.02 | 21332399 | |
| MESH:D006949 | Hyperlipidemias | Dietary Fats | 4.08 | 21332399 | |
| MESH:D007249 | Inflammation | Dietary Fats | 2.60 | 20412841 | |
| MESH:D007333 | Insulin Resistance | Dietary Fats | 3.34 | 18457598 11836018 | |
| MESH:D008103 | Liver Cirrhosis | Dietary Fats | 3.07 | 18296743 | |
| MESH:D009765 | Obesity | Dietary Fats | 2.36 | 21332399 11836018 20518802 19632207 17217161 20132043 18674790 16723640 18457598 | |
| MESH:D015430 | Weight Gain | Dietary Fats | 4.11 | 16723640 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:05160 | Hepatitis C |
| KEGG:05162 | Measles |
| KEGG:04141 | Protein processing in endoplasmic reticulum |