AutismKB 2.0

Annotation Detail for PDE7B


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Basic Information Top
Gene Symbol:PDE7B ( MGC88256,bA472E5.1 )
Gene Full Name: phosphodiesterase 7B
Band: 6q23.3
Quick LinksEntrez ID:27115; OMIM: 604645; Uniprot ID:PDE7B_HUMAN; ENSEMBL ID: ENSG00000171408; HGNC ID: 8792
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00230Purine metabolism
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of PDE7B mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDE7B mRNAaffects expression 16483693
D001554 Benzene Benzene results in decreased expression of PDE7B mRNAdecreases expression 15929907
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDE7B mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PDE7B mRNAaffects expression 17484886
C006253 pirinixic acid pirinixic acid results in increased expression of PDE7B mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PDE7B mRNAdecreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000741 Anemia, Aplastic Benzene 4.5811369114 14761424 17661222
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0718218290 20041841 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 4.1119698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 17.0219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 17.0219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 17.0212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001855 Bone Marrow Diseases Benzene 5.6716183116
MESH:D001943 Breast Neoplasms Benzene 2.1917162533 11921183
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1415673190 15700767 3786805 16097048 10355542 18705752 15721981 16192424 16227642 16124888 16011737 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9715710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4818974383
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 15340226 8697196 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 2.7415643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7410048152 15322242 20055451
MESH:D003872 Dermatitis Benzene 5.1315902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.6418218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.642869522 17522070 19085960 16227642 6884620 11566570 21278145 3732212 10915739 3786805 16177239 19336974 7440962 7120509 7179309 4309450 9327722 10092053 15968718 6623471 15998439 15027814
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Amiodarone 14.8414986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.8415959796 19224547 16045604 61145 12795759 17595544 12631006 16239168
MESH:D005234 Fatty Liver pirinixic acid 14.8419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.8218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8220067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006402 Hematologic Diseases Benzene 4.9616183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219900420 19110552
MESH:D006529 Hepatomegaly Amiodarone 16.6215265979
MESH:D006529 Hepatomegaly pirinixic acid 16.6216221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.6215340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 16354765 8697196 15340226 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006937 Hypercholesterolemia Amiodarone 4.159751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Benzene 5.6117940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007037 Hypothyroidism Amiodarone 4.8717991464 18020914
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007938 Leukemia Benzene 3.5114694614 15935818 18335105 17119257
MESH:D007951 Leukemia, Myeloid Benzene 4.6017506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7319478238
MESH:D008064 Lipidoses Amiodarone 3.7017567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9416221502 16943688 16239168 11408273 21278145 11903743 17157831 17174718 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5317976157 18395914 17944888 14512876 13678700 18472094 18429990 18006644 16027843 15370692 12445421 15730626 18205269 14620537 18420326 12958196 18481824 12546737 12667390 12649538 18339082 12632512 12666154 15925388 18418968 15673190 15650968 15818738 17525996 17557913 18263696 18251166 17640975 17481882 15362042 17714472 17721639 12632514 15893842 18472332 14716833 17869086 16116963 14748882 18317297 16192424 15876570 17922224 14716496 17698563 16033810 16136751 16011737 16638106 16015684 17805973 15052691 18412020 15123356 15338365 17766677 12898905 17565644 17708605 10355542 18054572 20821823 15996030 12609069 12389079 17900296 15931870 18705752 12586293 18279442 12741479 17823541 16248980 18187930 18210741 14724832 17631135 15057751 18376398 16097048 18277467 18156304 12445418 15959796 17761835 18166357 11481614 18395095
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1315830285 16246199 15720792 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.8619294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.8616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8616984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 10.8412562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.8415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.8412151625
MESH:D008133 Long QT Syndrome Amiodarone 3.7911989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.5512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 12.9918516814
MESH:D017563 Lung Diseases, Interstitial Benzene 12.9914698565
MESH:D008175 Lung Neoplasms Benzene 2.5612562636
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5619555203 11884234
MESH:D008223 Lymphoma Benzene 3.9317119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.8412562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.4711921183
MESH:D009101 Multiple Myeloma Benzene 3.8517119195
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009181 Mycoses Amiodarone 5.3412754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects Benzene 3.8415643154
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases Benzene 4.4417119257 15913788 15935809 16737584 15612468 15576619 15727169 17479406 17178637
MESH:D010051 Ovarian Neoplasms Benzene 3.0312562636
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11222880 11896295 11399792
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9412490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4818724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013276 Stomach Ulcer Amiodarone 3.5918087811
MESH:D013610 Tachycardia Amiodarone 4.6211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5219225199
MESH:D013953 Thymus Neoplasms Benzene 5.3510850423
MESH:D013959 Thyroid Diseases Amiodarone 13.5819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 13.5812697716
MESH:D013971 Thyrotoxicosis Amiodarone 5.2219584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.5917467628 11989578
MESH:D014594 Uterine Neoplasms Benzene 4.6612562636
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
KEGG:00230 Purine metabolism
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33140
    • No data
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    Releated drug ID Related drug Name
    PA449233desipramine
    PA449673fluoxetine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00651 antagonist Dyphylline Vasodilator Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Respiratory Smooth Muscle Relaxants
    DB00920 antagonist Ketotifen Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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