AutismKB 2.0

Annotation Detail for AFF4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:AFF4 ( AF5Q31,MCEF,MGC75036 )
Gene Full Name: AF4/FMR2 family, member 4
Band: 5q31.1
Quick LinksEntrez ID:27125; OMIM: 604417; Uniprot ID:AFF4_HUMAN; ENSEMBL ID: ENSG00000072364; HGNC ID: 17869
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of AFF4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AFF4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of AFF4 mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in increased expression of AFF4 mRNAincreases expression 19945496
C006632 arsenic trioxide arsenic trioxide results in decreased expression of AFF4 mRNAdecreases expression 20458559
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of AFF4 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AFF4 mRNAdecreases expression 19150397
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of AFF4 mRNAdecreases expression 16934159
C547156 dimethylthioarsinic acid dimethylthioarsinic acid results in increased expression of AFF4 mRNAincreases expression 19945496
D004958 Estradiol Estradiol results in decreased expression of AFF4 mRNAdecreases expression 20068009
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AFF4 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of AFF4 mRNAincreases expression 18445702
C025643 vinclozolin vinclozolin affects the expression of AFF4 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4819825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.4811473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3917306315
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D020261 Arsenic Poisoning Arsenic 2.8912569548 16251483 18414634 16835338
MESH:D050197 Atherosclerosis Arsenic 3.3119371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.3716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3719483382
MESH:D001943 Breast Neoplasms Estradiol 2.1317289903 16675129 19861407 12948864 17261762 14630087 17018787 18497071
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.6116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.6116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.613084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 11.6117306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.6115553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.6116924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7218922899 15504454 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1818640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5215738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4118022660 16973168
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.616135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6120889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.6118566989
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2617906064 11743745 14986274 12705907 19739265 16781746 11287661 14550746 11834606 12153990 10915739 19370779 16081117 16485898 16227642 19416960 16177239 17562736 19085960 12540782 12958197 16393943 16109766 11461765 15968718 11739529 17522070 10663392 19420014 18713872 10774834 11529661 2444490 14725611 11421492 18071297 12594235 15619225 19923254 19164858 12392966
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 9.2617851650
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.0519148513 11473722 18566989
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5412903497
MESH:D005234 Fatty Liver arsenic trioxide 8.0915073043
MESH:D005234 Fatty Liver pirinixic acid 8.0920131406 19236843
MESH:D005534 Foot Diseases Arsenic 5.736392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1319772884 18467677 19176532 16221962
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5617050553
MESH:D006973 Hypertension Arsenic 2.9016076760 11953799 9931084
MESH:D006987 Hypesthesia Arsenic 5.7316093927
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007333 Insulin Resistance Estradiol 7.4316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D007642 Keratosis Arsenic 5.1416930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 6.0812587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.0815618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9516705839
MESH:D007680 Kidney Neoplasms Estradiol 12.9515610895
MESH:D007938 Leukemia arsenic trioxide 2.8815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1520471514 16467208 17050201 19850784 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.0117339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.0117869043 12018890 11161223 17107899 19075265 16331271 16330433 19642359 19225113 17217047 12679006 15748426 16966277 16112521 15622746 19035177 15336539 12712474 11468182 17649720 17712046 16891316 15213294 9834237 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3315474484
MESH:D008107 Liver Diseases Acetaminophen 4.1511587558 16611625 12587719 12969438 16610002 19784758 19460945 19014921
MESH:D008107 Liver Diseases Arsenic 4.1511134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.047678174
MESH:D008113 Liver Neoplasms Arsenic 11.0416368122
MESH:D008113 Liver Neoplasms arsenic trioxide 11.0414682389
MESH:D008113 Liver Neoplasms pirinixic acid 11.0420007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.186135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.1820377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.1617365036
MESH:D008175 Lung Neoplasms Arsenic 2.6817306315 17976673 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 2.6811798837 19825857
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6216891317 11408345 11807958 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2216966607 18303189 16166281
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1819549372 19417148 11468182 14977855 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2016105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Arsenic 4.0715371236
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009421 Nervous System Malformations Estradiol 3.7811399458 16427766
MESH:D009436 Neural Tube Defects Arsenic 7.6816620997
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6810525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.4917056641
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D010051 Ovarian Neoplasms Arsenic 8.1117306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.1112452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 8.1119401270
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5615580305
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3016093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.146392382 15371236 16905509
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0310923243
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0518042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.5916140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5919131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D011507 Proteinuria Arsenic 4.1221343184
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0617365031 15814490 17322281 17975199
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012871 Skin Diseases Arsenic 2.7718709164 17050553 19834688 17453740 16353154 17548696 15952646 17938729 16759981 16702368 6392382
MESH:D012878 Skin Neoplasms Arsenic 3.0517976673 19538983 17050553 15504454 16251483 17029826
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1719014326
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.2816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.2816049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 12.2811144890 18640142 19322015 19429237 17976673 17306315 15987713
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.2820435036 12845720 11780464 12973940
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014652 Vascular Diseases Arsenic 4.8917056641
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved