AutismKB 2.0

Annotation Detail for CYTH4


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Basic Information Top
Gene Symbol:CYTH4 ( CYT4,DJ63G5.1,PSCD4 )
Gene Full Name: cytohesin 4
Band: 22q13.1
Quick LinksEntrez ID:27128; OMIM: 606514; Uniprot ID:CYH4_HUMAN; ENSEMBL ID: ENSG00000100055; HGNC ID: 9505
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in decreased expression of CYTH4 mRNAdecreases expression 17942131
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CYTH4 mRNAdecreases expression 17942131
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of CYTH4 mRNAdecreases expression 17942131
D003474 Curcumin Curcumin results in increased expression of CYTH4 mRNAincreases expression 17198877
D016572 Cyclosporine Cyclosporine results in decreased expression of CYTH4 mRNAdecreases expression 17942131
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D019973 Alcohol-Related Disorders Curcumin 5.6917887948
MESH:D000544 Alzheimer Disease Curcumin 2.6715590663
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.8016807698
MESH:D050197 Atherosclerosis Curcumin 3.5118704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 4.9819761891
MESH:D002545 Brain Ischemia Curcumin 4.8716770732
MESH:D001932 Brain Neoplasms Curcumin 4.2817596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2420146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 2.2418462866 19250217 16243823 18593918
MESH:D002277 Carcinoma Curcumin 4.1218593918
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0718414057
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.0220419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 5.0218462866
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D003092 Colitis Curcumin 4.6616804969 16782535 18200517
MESH:D003103 Coloboma Curcumin 4.9218809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5519359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.3818497527
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7718403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.3318204486
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6612958197 15968718 15619225 19085960 2444490 18071297 14550746 12705907 16393943 10915739 12540782 16081117 10774834 16109766 19164858 17906064 17522070 14986274 16227642 11287661 11834606 16177239 19420014 19739265 16485898 19416960 11421492 18713872 19370779 11461765 12153990 14725611 12392966 11739529 19923254 11743745 11529661 16781746 10663392 17562736 12594235
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004381 Duodenal Ulcer Curcumin 4.4917351913
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Curcumin 9.1719297423
MESH:D005234 Fatty Liver Cyclosporine 9.1719224547
MESH:D005355 Fibrosis Curcumin 10.5218705752
MESH:D005355 Fibrosis Cyclosporine 10.5212168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.1818462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D005909 Glioblastoma Curcumin 3.6917596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8818462866 18829502
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.5217701891
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006937 Hypercholesterolemia Curcumin 4.4318704882
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007249 Inflammation Curcumin 3.0517151092 18403477 16956363
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3218596194 18200517
MESH:D007414 Intestinal Neoplasms Curcumin 4.5710783313
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 6.4115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.4118776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D007889 Leiomyoma Curcumin 4.9818555241
MESH:D007938 Leukemia Curcumin 3.3918462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.5816106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.2016106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.2818006644 18705752 17355460
MESH:D008107 Liver Diseases Acetaminophen 4.3419784758 16611625 12969438 11587558 19460945 19014921 12587719 16610002
MESH:D008107 Liver Diseases Curcumin 4.3416956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1421137059 20195826
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6418816296 18569708 20135361 20464547 6695378 17053015 20869020 18520028 20064080
MESH:D008175 Lung Neoplasms Curcumin 2.6416243823 19359593 18462866
MESH:D008223 Lymphoma Curcumin 3.8318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.1816173963
MESH:D008545 Melanoma Curcumin 2.4517885582 18462866
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008569 Memory Disorders Curcumin 4.5917263510
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009101 Multiple Myeloma Curcumin 3.7619372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.4617962980
MESH:D009361 Neoplasm Invasiveness Curcumin 4.8118495463
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 5.1412497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6118481113 19348381
MESH:D009423 Nervous System Neoplasms Curcumin 6.2418462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity Curcumin 2.8119297423
MESH:D010024 Osteoporosis Curcumin 3.6718719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.9018462866 19020741
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0319401701 19196508 17440100
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2517292933
MESH:D011471 Prostatic Neoplasms Curcumin 3.2515129424 18769126 12497104 11398177 18226269 10851300 18156803
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.8819168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.4318379247 10666014
MESH:D012509 Sarcoma Curcumin 4.4618462866
MESH:D018805 Sepsis Curcumin 4.3818389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Curcumin 3.8616631530 19188055
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5817053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.5818593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.8018462866
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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