AutismKB 2.0

Annotation Detail for KCNH5


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Basic Information Top
Gene Symbol:KCNH5 ( EAG2,H-EAG2,Kv10.2 )
Gene Full Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Band: 14q23.2
Quick LinksEntrez ID:27133; OMIM: 605716; Uniprot ID:KCNH5_HUMAN; ENSEMBL ID: ENSG00000140015; HGNC ID: 6254
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KCNH5 mRNAaffects expression 17562736
D019386 Alendronate Alendronate affects the expression of KCNH5 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNH5 mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KCNH5 mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KCNH5 mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of KCNH5 mRNAaffects expression 16079270
C025299 polyphenols polyphenols results in decreased expression of KCNH5 mRNAdecreases expression 16293270
D020849 Raloxifene Raloxifene affects the expression of KCNH5 mRNAaffects expression 16079270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma Diethylnitrosamine 2.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2417162532 19052882 16434500 19061943 18056438 17620307
MESH:D000419 Albuminuria Raloxifene 4.8817451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001930 Brain Injuries Raloxifene 4.7816580743
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3017474063
MESH:D001943 Breast Neoplasms Raloxifene 2.3015572757 17261762 16912660 17952589 15758505 17595753 17893378 16837676 17049068 15775269 17440819 17242785
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9416807293 17978847 19107877 19919837 18978308 20432363 20007298 16569478 20512989 17055752 19519916 18494052 11831363 16502159 16698587 19171122 10737359 16328049 17162532 18506893 19335982 18788625 18056438 19208518 16830150 16878318 20935162 10672840 18665156 17173139 20084675 17761372 18691550 16288022 19539802 17138121 21159647 16935385 16681979 20214788 19394651 20514400 18971187 18393292 17428255 20727157 20101231 19052882 16540662 19701751 3581430 3084413 19383236 18210153 16779866 20524982 19822196 18785209 19418558
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.3017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6015775269
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.012727394 7505956 21159647 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0517681005 11677210 16919318 15861022 16105132 17333356 17110522
MESH:D003072 Cognition Disorders Raloxifene 4.9215800139
MESH:D003110 Colonic Neoplasms polyphenols 2.7016293270
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3817474826
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D003928 Diabetic Nephropathies Raloxifene 4.1515920148 17308373 17451421
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6414550746 14725611 16485898 11461765 11739529 18071297 19370779 16781746 15619225 10915739 11743745 16177239 10663392 12705907 17562736 17906064 16393943 19416960 18713872 16081117 11529661 19164858 19420014 16227642 12392966 16109766 12540782 12594235 10774834 19739265 12153990 15968718 2444490 11287661 19923254 17522070 19085960 12958197 11421492 14986274 11834606
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6419107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.6419370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema Raloxifene 3.5815860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.0715845917
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005234 Fatty Liver Diethylnitrosamine 14.6221071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.6215345470
MESH:D005234 Fatty Liver Raloxifene 14.6217473493
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006331 Heart Diseases Raloxifene 3.6911110106
MESH:D006930 Hyperalgesia Acetaminophen 8.8216870215
MESH:D006930 Hyperalgesia Alendronate 8.8216769263
MESH:D006973 Hypertension Raloxifene 2.9415787275 17577099
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Diethylnitrosamine 5.7118785209
MESH:D007249 Inflammation polyphenols 5.7116366677
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.8110783313
MESH:D007674 Kidney Diseases Acetaminophen 6.6615629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.6615369732
MESH:D007889 Leiomyoma Raloxifene 4.7616973256
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1416766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9419638242 18522880 18407596 18665156 20032147
MESH:D008107 Liver Diseases Acetaminophen 6.8816610002 19014921 12587719 12969438 19460945 19784758 11587558 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 6.8817034775
MESH:D008107 Liver Diseases polyphenols 6.8816698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.3119996281 20452335 19427195 18648771 9163691 21278145 15885732 15175105 20118626 20101389 16942905 19254457 19642983 12112319 20501860 19812893 20405173 19499222 10737359 19638242 21047994 20137499 21071580 12771043 2862719 19294768 19551842 18977376 20492335 18644402 2422723 18754104 19833225 19426721 19690152 18978307 19073162 20434301 20583210 19850985 21167192 19256749 19090486 19255062
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7716267830 17942915 19009564 19126423 18544905 9362446 18775883 16842330 19539802 18164116 18079962 3124819 19519916 19004024 17174075 18093689 2563599 18308698 18282651 17854601 21159647 18253720
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 20512841 21163286
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.9315863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6016497877
MESH:D009232 Myxoma Raloxifene 5.9316343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D010024 Osteoporosis Alendronate 8.2517882678
MESH:D010024 Osteoporosis Raloxifene 8.2517882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4917823083 15758505 15579764 17893378
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5715731164 16220300 16536755
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D011693 Purpura Raloxifene 5.9315770314
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Raloxifene 4.0116837676
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.6317997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D013978 Tibial Fractures Raloxifene 5.5819048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8917572228
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054556 Venous Thromboembolism Raloxifene 5.5816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.9316343187
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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